What is Dexilant 30 mg used to treat?
Dexilant (dexlansoprazole) is a powerful proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach. Unlike other PPIs, Dexilant utilizes a specialized dual-delayed release mechanism, which releases the medication at two distinct times to provide sustained acid suppression. The 30 mg dose is indicated for specific therapeutic uses in adults and children aged 12 and older.
Indications for Dexilant 30 mg
Your healthcare provider may prescribe Dexilant 30 mg for one of two main purposes:
- Maintaining the healing of erosive esophagitis: For patients who have already completed an initial 8-week course of therapy (typically with a 60 mg dose) to heal the esophageal lining, the 30 mg dose serves as a maintenance therapy. This helps to prevent erosive esophagitis from recurring and provides ongoing relief from related heartburn. In adults, this maintenance phase can last for up to six months.
- Treating symptomatic non-erosive gastroesophageal reflux disease (GERD): The 30 mg dose is used for the short-term treatment of heartburn associated with symptomatic, non-erosive GERD. The typical treatment duration for this condition is four weeks. This is for individuals who experience heartburn and other GERD symptoms without visible damage to the esophageal lining.
The Science Behind the Dual-Delayed Release
The effectiveness of Dexilant is largely due to its unique formulation, which is engineered to release the active drug, dexlansoprazole, at different times and locations within the digestive system. The dual-delayed release capsule contains two types of granules:
- One type of granule releases the medication in the proximal (upper) part of the intestine, shortly after administration.
- The second type of granule releases the remaining medication in the distal (lower) part of the intestine, several hours later.
This two-part release profile helps to provide a more consistent and prolonged acid-suppressing effect over a 24-hour period. This continuous acid control is particularly beneficial for individuals whose symptoms might otherwise return overnight or between doses with a traditional single-release PPI.
Important considerations and side effects
While Dexilant is effective for its indicated uses, it is crucial to be aware of potential side effects and long-term considerations. Like other PPIs, it works by significantly reducing stomach acid, which can have downstream effects on nutrient absorption and overall health.
Potential risks with long-term use
- Bone Fractures: Studies suggest that prolonged, high-dose PPI therapy may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. The lowest effective dose for the shortest duration should be used, especially in at-risk patients.
- Vitamin B12 Deficiency: Long-term acid suppression can lead to malabsorption of vitamin B12. Patients on Dexilant for an extended period, particularly over three years, should be monitored for B12 levels.
- Low Magnesium Levels (Hypomagnesemia): PPI use for three months or more can cause low magnesium levels. This can lead to symptoms like muscle spasms, irregular heartbeat, and seizures.
- Fundic Gland Polyps: Use for longer than a year increases the risk of developing these benign (non-cancerous) stomach growths.
Common side effects
- Diarrhea
- Abdominal pain
- Nausea
- Vomiting
- Gas
Comparing Dexilant to other PPIs
Dexilant is one of several PPIs available, each with its own characteristics. Here is a comparison of Dexilant with some other common PPIs, based on search results.
| Feature | Dexilant (Dexlansoprazole) | Prilosec (Omeprazole) | Nexium (Esomeprazole) | Protonix (Pantoprazole) |
|---|---|---|---|---|
| Release Mechanism | Dual-delayed release | Single-release | Single-release | Single-release |
| Dosing Schedule | Once daily, without regard to food | Once daily (usually before meals) | Once daily (usually before meals) | Once daily (usually before meals) |
| Main Advantage | Sustained 24-hour acid control, flexible dosing time | Wide availability, over-the-counter options | Effective for treating non-erosive GERD and other conditions | IV formulation available for hospital use; generally well-tolerated |
| Cost | Brand-name drug; often more expensive | Generic available (Omeprazole); more affordable | Generic available (Esomeprazole); less expensive than brand | Generic available (Pantoprazole); more affordable |
Conclusion
Dexilant 30 mg is an effective prescription medication used for managing long-term symptoms of healed erosive esophagitis and providing short-term relief from symptomatic GERD. Its unique dual-delayed release mechanism provides sustained acid control, offering a significant advantage for those who experience persistent symptoms. While generally well-tolerated, it is vital to discuss the potential for long-term side effects with your healthcare provider, especially if you require extended treatment. Pairing medication with lifestyle adjustments, such as dietary changes and weight management, is often the most comprehensive approach to controlling acid reflux disorders. Always consult your doctor to determine if Dexilant 30 mg is the right treatment for your specific condition and to understand all associated risks and benefits.
Disclaimer: The information provided is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before starting or stopping any medication.
