Understanding Qlaira: A Unique Quadriphasic Oral Contraceptive
Qlaira is a combined oral contraceptive (COC) that contains estradiol valerate and dienogest. Unlike many COCs using synthetic ethinylestradiol and consistent dosing, Qlaira is quadriphasic, featuring four different hormone dosing levels over a 28-day cycle to mimic natural fluctuations. This includes 26 active and two inactive tablets. This design may offer improved bleeding control and fewer side effects for some users.
How Qlaira Works
Qlaira prevents pregnancy through the combined actions of its hormones. This includes inhibiting ovulation, thickening cervical mucus to impede sperm, and altering the uterine lining to prevent implantation. Consistent use ensures high effectiveness.
Primary Benefits of Taking Qlaira
Qlaira is primarily indicated for contraception but is also approved for treating heavy menstrual bleeding (menorrhagia) in women seeking oral contraception.
Improved Menstrual Health
Qlaira can significantly improve menstrual health. Clinical trials show a median reduction of 81% in menstrual blood loss for women with menorrhagia. It also helps regulate cycles, resulting in lighter and more predictable periods. Additionally, many users experience reduced period pain and cramps.
Potential Additional Advantages
Beyond menstrual benefits, Qlaira may offer other advantages, such as improving acne due to dienogest's antiandrogenic properties. The stable hormone levels may also help stabilize mood and reduce premenstrual symptoms. Dienogest may also help reduce pelvic and period pain associated with endometriosis.
Qlaira vs. Other Combined Oral Contraceptives
Comparing Qlaira to standard monophasic COCs can highlight its unique features.
| Feature | Qlaira (Estradiol Valerate/Dienogest) | Standard Monophasic COC | Potential Advantage of Qlaira | Citations |
|---|---|---|---|---|
| Hormone Type | Contains estradiol valerate, metabolizing to natural 17ß-estradiol. | Contains synthetic ethinyl estradiol. | May have a different side effect profile due to a more natural estrogen form. | , |
| Dosing Regimen | Quadriphasic, four dose levels over 28 days. | Monophasic, fixed dose over 21 days. | Could minimize hormonal fluctuations and withdrawal symptoms by mimicking the natural cycle. | , |
| Menstrual Bleeding | Approved for heavy menstrual bleeding, often leading to lighter periods or no bleeding. | Regulates periods, but not specifically indicated for menorrhagia. | Potentially more effective at reducing heavy bleeding. | , |
| Period Pain | Often reduces period pain due to effects on the uterine lining. | Can reduce period pain, with variable effectiveness. | Stable hormones may offer more consistent pain relief. | , |
| Androgen Effects | Dienogest has antiandrogenic activity, potentially improving acne. | Acne effectiveness depends on the progestin type. | Specific progestin may benefit those with hormonal acne. | , |
Important Considerations and Potential Side Effects
Like all medications, Qlaira has potential risks and side effects. A healthcare provider will assess your suitability based on medical history.
Common Side Effects
Common initial side effects may include headaches, nausea, breast tenderness, irregular bleeding, weight changes, mood changes, and changes in libido.
Serious Risks
Rare but serious risks of combined hormonal contraceptives like Qlaira include increased risk of blood clots, heart attack, and stroke, especially in the first year of use. There's also an increased risk of certain cancers, liver issues, and high blood pressure.
Contraindications
Qlaira is not suitable for women with a history of blood clots, heart attack, stroke, certain blood disorders, liver disease, certain cancers, unexplained vaginal bleeding, or migraines with aura. It should not be used during pregnancy or breastfeeding. Smoking women over 35 should avoid combined oral contraceptives due to increased cardiovascular risk. Always consult a healthcare professional for detailed information.
Conclusion: Is Qlaira the Right Choice for You?
Qlaira offers significant benefits beyond contraception, such as reducing heavy periods and pain, and potentially improving acne, thanks to its unique formulation. However, potential risks and side effects must be discussed with a healthcare provider. The decision to use Qlaira should be personalized based on your health needs and risk factors to maximize benefits and minimize harm. For further clinical information, the Review of the safety, efficacy and patient acceptability of the Qlaira® (estradiol valerate/dienogest) oral contraceptive is available from the National Institutes of Health.
