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What are the best drops for dry eyes: OTC and Prescription Options

3 min read

According to a 2023 systematic review, artificial tears effectively improve dry eye symptoms within a month of regular use. When seeking what are the best drops for dry eyes, understanding the types available is key. This guide helps navigate various options, from mild relief to chronic condition management.

Quick Summary

Eye drops for dry eyes range from over-the-counter options like artificial tears, gels, and lipid-based drops to prescription medications that treat underlying causes like inflammation or specific tear film imbalances.

Key Points

  • Start with OTC Artificial Tears: For mild, occasional dry eyes, lubricating artificial tears from brands like Systane or Refresh are the recommended starting point.

  • Consider Preservative-Free Options: If you need to use drops more than four times a day or have sensitive eyes, preservative-free artificial tears are the safer choice to avoid irritation.

  • Choose Based on Your Dry Eye Type: Lipid-based drops (e.g., Systane Complete PF) are best for evaporative dry eye (MGD), while standard artificial tears address aqueous-deficient dry eye.

  • Use Thicker Gels or Ointments for Nighttime: Gels and ointments provide longer-lasting relief, which is ideal for overnight use, but they can cause temporary blurry vision.

  • Consult an Eye Doctor for Chronic Symptoms: If OTC drops are not providing relief, see an eye care professional. Chronic dry eye often requires prescription treatments like Restasis, Xiidra, or Miebo to address the underlying cause.

  • Use Complementary Therapies: Lifestyle adjustments like using a humidifier, taking omega-3 supplements, and applying warm compresses can be used alongside eye drops to improve symptoms.

In This Article

Understanding Dry Eye Syndrome

Dry eye syndrome (DED) occurs when the eyes don't produce enough tears or tears evaporate too quickly. A healthy tear film has three layers—oil, water, and mucus—and an imbalance in any layer can cause irritation.

Common types include:

  • Aqueous-deficient dry eye: Reduced watery tear production.
  • Evaporative dry eye: Caused by issues with oil production, leading to rapid tear evaporation.

Best Over-the-Counter Eye Drops

Over-the-counter (OTC) options are often the first step for mild to moderate dry eye. Artificial tears are widely used to supplement natural tears. These drops commonly contain ingredients such as carboxymethylcellulose, glycerin, or polyethylene glycol. Some popular brands include Systane Ultra, Refresh Tears, and TheraTears.

For more severe dryness, thicker options like gel drops or ointments provide longer-lasting relief, especially overnight, though ointments can cause temporary blurred vision. Lipid-based drops are designed for evaporative dry eye and contain oils to help the tear film's lipid layer. Examples include Systane Complete PF and Refresh Optive Mega-3. Those using drops frequently or with sensitive eyes may prefer preservative-free options to avoid irritation.

Best Prescription Drops for Dry Eyes

If OTC drops aren't enough, a doctor may prescribe stronger medications.

Anti-inflammatory drops like Cyclosporine (Restasis, Cequa, Vevye) help increase natural tear production over several months. Lifitegrast (Xiidra) blocks inflammatory proteins and may offer quicker relief.

Other prescription options include Miebo for evaporative dry eye, Eysuvis for short-term flares, Tyrvaya (a nasal spray) to stimulate tears, and custom Autologous Serum Tears for severe cases.

Top OTC Eye Drops Comparison

Product Best For Preservative Viscosity
Systane Ultra All-day hydration, screen-related dryness Available with or without Liquid
Systane Complete PF Evaporative dry eye (MGD) and sensitive eyes Preservative-free Liquid
Refresh Tears Mild to moderate, general dryness Preserved Liquid
Refresh Celluvisc Severe dryness, nighttime use, sensitive eyes Preservative-free Gel
Biotrue Hydration Boost Contact lens wearers and sensitive eyes Preservative-free Liquid
Soothe XP Evaporative dry eye (MGD) due to mineral oil Preserved Liquid

Important Considerations for Choosing Drops

Choosing between preservative-free and preserved drops is important, especially for frequent users or those with sensitivity. Viscosity matters too: liquids are quick, gels last longer with brief blur, and ointments offer maximum overnight relief but cause significant temporary blur. Contact lens wearers should be cautious, often needing to remove lenses before applying drops not specifically made for contacts. Professional guidance from an eye doctor is crucial for diagnosis and selecting the most effective treatment, particularly if OTC options aren't working.

Alternative and Complementary Therapies

Managing dry eye can also involve other approaches:

Conclusion

Identifying the best drops for dry eyes depends on the cause and severity of symptoms. OTC artificial tears are a good starting point for milder cases. For persistent or severe dry eye, prescription treatments that target underlying issues may be necessary. Consulting an eye care professional is recommended to get a proper diagnosis and tailored treatment plan.

Frequently Asked Questions

Preserved drops contain chemicals to prevent bacterial growth and are suitable for occasional use. Preservative-free drops are recommended for frequent use or sensitive eyes, as preservatives can cause irritation.

Most eye drops, especially preserved ones, should not be used while wearing contacts. Remove lenses, apply drops, and wait at least 15 minutes before reinserting. Look for drops specifically labeled as safe for contact lenses.

An eye care professional can diagnose the specific type of dry eye through tests to determine if the issue is poor oil production (evaporative) or low tear volume (aqueous-deficient).

Consult an eye doctor if symptoms persist, worsen, or don't improve with OTC drops. They can diagnose the cause and recommend a personalized plan.

Some prescription drops like Xiidra may offer quicker relief, while others like Restasis take months as they treat the underlying inflammation. OTC drops provide immediate, temporary symptom relief.

Common side effects include temporary blurred vision or mild irritation, especially with thicker drops. Prescription drops can have specific side effects like redness or unusual taste. Allergic reactions are rare.

Yes, natural methods include blinking more, using warm compresses, staying hydrated, and omega-3 supplements. Using a humidifier can also help.

Recent advances include new prescription drops like Miebo and Tyrvaya, as well as in-office procedures such as IPL therapy and thermal pulsation therapy, which target underlying causes.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.