What are the side effects of hemorrhoid pills? A Comprehensive Guide

October 8, 2025 •

4 min read

While millions of people worldwide experience hemorrhoid symptoms, using oral medications can provide relief. For safe and effective treatment, it is crucial to understand what are the side effects of hemorrhoid pills, which often contain bioflavonoids to strengthen blood vessels.

Quick Summary

This guide details the potential side effects of oral hemorrhoid medications, primarily bioflavonoid supplements like diosmin. It covers common reactions, including gastrointestinal discomfort and headaches, as well as the signs of rare but serious allergic reactions. Important safety considerations and comparative information on other hemorrhoid treatments are also discussed.

Key Points

Gastrointestinal Distress: The most common side effects of oral hemorrhoid pills, like diosmin, include nausea, vomiting, diarrhea, and indigestion.
Headaches and Dizziness: Some patients may experience headaches or dizziness when taking bioflavonoid supplements for hemorrhoids.
Rare Allergic Reactions: In rare cases, a severe allergic reaction (anaphylaxis) can occur, with symptoms including hives, swelling, and difficulty breathing.
Systemic Side Effects: The potential for systemic absorption of some components exists, though rarely, leading to less common side effects like mood changes or other widespread effects.
Not for Long-Term Use: Prolonged use of oral treatments is not always recommended, and patient history, including allergies, must be considered before use.
Consult a Professional: Always discuss treatment with a doctor, especially if you have underlying conditions or if symptoms do not improve.

Hemorrhoids can be painful and inconvenient, but for some, oral medication offers a way to manage symptoms internally. The term "hemorrhoid pills" most commonly refers to dietary supplements or prescription tablets containing bioflavonoids, such as diosmin and hesperidin. These compounds are believed to help by improving blood flow and toning venous walls to reduce congestion. However, as with any medication, they come with potential side effects that users should be aware of.

Common Side Effects of Oral Hemorrhoid Medication

For many patients, the side effects experienced are mild and transient. Gastrointestinal issues are the most frequently reported adverse effects associated with bioflavonoid pills like those found in Daflon and Hemovel.

Gastrointestinal Distress: This is the most common category of side effects. Users may experience:
- Diarrhea
- Nausea
- Vomiting
- Indigestion or stomach pain
Headaches: Some individuals report experiencing headaches after taking diosmin-based pills.
Dizziness: Dizziness or lightheadedness can occur in some cases, although it is not a widespread issue.

These common side effects often resolve as the body adjusts to the medication. Taking the pills with meals, as often directed, can help mitigate some of the gastrointestinal discomfort.

Rare or Severe Side Effects

While infrequent, some severe side effects and adverse reactions can occur. It is important to know the signs so that you can seek immediate medical attention if necessary.

Severe Allergic Reactions (Anaphylaxis): Though very rare, a serious allergic reaction is possible. Symptoms can include:
- Hives or a rash
- Itching and swelling, particularly of the face, tongue, or throat
- Severe dizziness or fainting
- Trouble breathing
Mental or Mood Changes: In extremely rare instances, systemic absorption of certain medication components can lead to mental or mood changes.

Important Considerations and Precautions

Before starting any oral hemorrhoid treatment, it is crucial to discuss your medical history and current health with a healthcare professional. Several factors can influence the risk of side effects.

Allergies: Individuals with known allergies to any components of the medication, such as diosmin, should not use the product.
Underlying Conditions: People with pre-existing conditions, particularly liver disease, should exercise caution and consult their doctor.
Pregnancy and Breastfeeding: The use of oral bioflavonoids during pregnancy or breastfeeding is not well-studied in all contexts, and a healthcare provider should be consulted to weigh the risks and benefits.

Comparing Oral vs. Topical Hemorrhoid Treatments

For a holistic understanding of hemorrhoid treatment options, it is useful to compare the side effect profiles of oral pills with those of topical treatments, such as creams and suppositories. Topical products, which contain ingredients like hydrocortisone, phenylephrine, or witch hazel, act locally and have a different set of potential side effects.


Feature	Oral Medication (e.g., Diosmin/Hesperidin Pills)	Topical Medication (e.g., Hydrocortisone Cream/Suppository)
Mechanism	Works systemically to tone veins and improve circulation.	Applied directly to shrink swollen tissue, numb pain, or protect skin.
Common Side Effects	Gastrointestinal upset, headache, dizziness.	Local irritation, burning, stinging, itching.
Severe Side Effects	Rare allergic reactions (anaphylaxis).	Systemic absorption (rare) leading to more widespread corticosteroid effects; skin thinning with prolonged use.
Speed of Relief	Symptom improvement may take several days to appear.	Often provides more immediate relief of local symptoms like itching and pain.
Primary Target	Internal hemorrhoids and generalized venous insufficiency.	External hemorrhoids and external symptoms of internal hemorrhoids.

What to Do If You Experience Side Effects

If you experience any side effects from hemorrhoid pills, the appropriate action depends on the severity of the reaction. For common, mild side effects like minor gastrointestinal discomfort, you can try adjusting the timing of your dose (e.g., taking with a full meal) and ensuring adequate hydration. If these effects persist or worsen, or if you experience any signs of a serious allergic reaction such as swelling or difficulty breathing, stop taking the medication immediately and seek emergency medical help. Reporting side effects to a healthcare provider is always recommended so they can adjust your treatment plan or rule out other issues.

The Role of Oral Laxatives and Supplements

Beyond bioflavonoids, some oral products for hemorrhoid management include fiber supplements and stool softeners. These are not strictly "hemorrhoid pills" but are often used in conjunction with other treatments. Oral bisacodyl, a laxative, can cause stomach pain, discomfort, and cramping. Fiber supplements, when introduced too quickly, can cause gas and bloating. By softening stools, these medications help prevent straining, which can exacerbate hemorrhoid symptoms.

Conclusion

Understanding what are the side effects of hemorrhoid pills is essential for safe and effective self-care. Oral bioflavonoid supplements like diosmin and hesperidin most commonly cause mild gastrointestinal issues, headaches, and dizziness. More severe side effects, such as allergic reactions, are rare but require immediate attention. By being informed about the potential risks and working closely with a healthcare provider, individuals can choose the most appropriate treatment and manage any side effects effectively. Remember, all medication, including over-the-counter options, should be used with caution and only after proper consultation.

For more detailed information, consult authoritative sources such as the National Institutes of Health (NIH).

Frequently Asked Questions

The most common side effects of oral hemorrhoid medications, specifically bioflavonoid supplements, are gastrointestinal issues such as diarrhea, nausea, vomiting, and indigestion.

Oral hemorrhoid pills are generally considered safe for most users, but they do carry a risk of side effects. It is important to discuss your medical history and any other medications you are taking with a healthcare provider before use.

Consult a healthcare professional before using hemorrhoid pills or any other medication while pregnant or breastfeeding. The risks and benefits should be discussed with a doctor, as the effects on an unborn baby or nursing infant may not be fully known.

Oral pills primarily cause internal side effects like gastrointestinal upset, while topical creams and suppositories often produce local reactions such as irritation, burning, or stinging at the application site.

Signs of a serious allergic reaction can include a rash, hives, swelling of the face or throat, severe dizziness, or trouble breathing. If you experience these symptoms, stop using the medication and seek emergency medical help immediately.

Yes, some people have reported experiencing headaches or dizziness as a side effect of oral hemorrhoid medications that contain diosmin and hesperidin.

If your symptoms do not improve after using an over-the-counter treatment for about a week, you should contact your doctor or nurse. They can rule out other conditions and recommend further treatment.