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What Are the Side Effects of Tessalon Perles? An Overview of Benzonatate Risks

5 min read

According to prescribing information, severe hypersensitivity reactions are possible if Tessalon Perles are chewed or sucked instead of swallowed whole. Understanding what are the side effects of Tessalon Perles is crucial for safe and effective use of this prescription cough suppressant medication.

Quick Summary

Tessalon Perles (benzonatate) can cause side effects ranging from common issues like dizziness and headache to rare but serious risks, especially if the capsule is not swallowed whole.

Key Points

  • Swallow Capsules Whole: Never chew, crush, or suck Tessalon Perles, as this can cause severe local anesthesia in the mouth and throat, potentially leading to choking and severe allergic reactions.

  • Common Side Effects: The most frequent adverse reactions include drowsiness, headache, dizziness, nausea, and constipation.

  • Serious Central Nervous System Effects: Rare but serious CNS issues can occur, such as mental confusion and visual hallucinations, sometimes associated with concurrent medication use.

  • Fatal Risk for Children: Accidental ingestion by children under 10 years of age can be fatal, with overdose symptoms appearing rapidly.

  • Use Caution with Activities: Because of potential drowsiness and dizziness, users should avoid driving or operating machinery until they are aware of how the medication affects them.

  • Immediate Medical Help for Overdose: Symptoms of overdose can include restlessness, tremors, seizures, and loss of consciousness, requiring immediate emergency medical care.

  • Monitor for Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur and require urgent medical intervention.

In This Article

Before taking any medication, including Tessalon Perles, it is essential to consult with a healthcare professional. Information provided here is for general knowledge and should not be considered medical advice.

Tessalon Perles, known generically as benzonatate, is a non-narcotic prescription medication used to relieve and suppress coughs. It works by anesthetizing, or numbing, the cough reflex sensors in the lungs and respiratory passages. While effective for many, it is essential for patients to be aware of the potential side effects, which can range from mild and common to severe and life-threatening, particularly if the medication is not taken correctly.

Common Side Effects

For most people who take Tessalon Perles as prescribed, side effects are usually mild. The most frequently reported adverse reactions affect the central nervous system (CNS) and the gastrointestinal (GI) tract. While these are not experienced by everyone, they are the most common issues to watch for.

  • Drowsiness and Dizziness: These are two of the most frequent CNS-related side effects. Because Tessalon Perles can cause sedation, patients are advised to exercise caution when driving or operating heavy machinery until they know how the medication affects them.
  • Headache: Mild to moderate headaches can occur in some individuals taking the medication.
  • Nausea and Upset Stomach: GI issues such as nausea, upset stomach, and indigestion are commonly reported side effects. Taking the medication with food may help alleviate these symptoms.
  • Constipation: Changes in bowel habits, specifically constipation, are another common side effect.
  • Nasal Congestion: A stuffy nose or nasal congestion can occur in some users of benzonatate.
  • Skin Reactions: Mild dermatological issues, such as itching or a rash, have also been reported.

Less Common and Rare Side Effects

Beyond the more common reactions, a smaller percentage of users may experience less frequent but notable side effects. These reactions can sometimes be a sign of a more serious underlying issue or an improper administration.

  • Mental Confusion and Hallucinations: Although rare, some individuals have reported experiencing mental confusion or visual hallucinations while taking Tessalon Perles. These instances have sometimes been linked to taking the medication alongside other prescribed drugs.
  • Eye Irritation: A burning sensation in the eyes has been reported as a less common side effect.
  • Chest Numbness: A feeling of numbness or tingling in the chest can occur, which is usually not serious but can be alarming. This is different from the choking feeling associated with chewing the capsule, though both involve numbing effects.
  • Chills: Some individuals may experience a vague “chilly” sensation while on the medication.

Serious Side Effects and Risks

While rare, some side effects can be severe and require immediate medical attention. The most critical risks are tied to improper use or accidental ingestion.

The Danger of Chewing or Sucking the Capsule

One of the most significant risks associated with Tessalon Perles comes from improperly taking the medication. The capsules must be swallowed whole. Chewing, sucking, or crushing the capsules releases the benzonatate into the mouth, causing a temporary, localized anesthesia. This can lead to:

  • Oropharyngeal Anesthesia: Rapid numbing of the mouth, tongue, and throat.
  • Choking Hazard: The numbness can impair the ability to swallow, creating a serious risk of choking.
  • Severe Allergic Reactions: For some, this local anesthetic effect can trigger severe hypersensitivity reactions, including bronchospasm (constriction of airways), laryngospasm (spasms of the vocal cords), and even cardiovascular collapse.

Overdose Warning, Especially for Children

Accidental ingestion of Tessalon Perles, especially by children under 10, has been linked to a high risk of fatality. Overdose symptoms can appear as quickly as 15 to 20 minutes after ingestion and can lead to death within an hour. The capsules, which look similar to candy or jelly beans, are particularly attractive to young children.

Overdose symptoms include:

  • Restlessness and tremors.
  • Convulsions or seizures.
  • Coma and profound CNS depression.
  • Cardiac arrest.

If a child or anyone else accidentally ingests Tessalon Perles, seek immediate emergency medical help.

Tessalon Perles vs. Other Cough Suppressants: A Side Effect Comparison

When considering cough relief options, comparing the side effect profiles of different medications can be helpful. Here is a comparison of benzonatate (Tessalon Perles) with two common alternatives: the opioid codeine and the non-opioid dextromethorphan (DM).

Feature Benzonatate (Tessalon Perles) Codeine Dextromethorphan (DM)
Mechanism Anesthetizes nerves in the lungs and airways. Acts as a CNS opioid, depressing the cough center. Works centrally on the brain to suppress the cough reflex.
Common Side Effects Drowsiness, headache, dizziness, nausea, constipation. Constipation, sedation, nausea, vomiting, itching. Nausea, stomach upset, mild drowsiness.
Dependence Risk No risk of dependency. High risk of physical and psychological dependence. No risk of dependence at normal usage.
Serious Risks Severe allergic reactions, choking risk if chewed, fatal overdose possible. Severe respiratory depression, especially with alcohol or other CNS depressants. Serotonin syndrome when combined with certain medications (SSRIs, MAOIs).
Availability Prescription only. Prescription only (due to opioid class). Over-the-counter (OTC).
Child Safety Fatal in children under 10, major safety concern. Potentially fatal respiratory depression in children and those with specific genetic variations. Generally considered safe for children as directed, but still potential for misuse.

How to Minimize the Risk of Side Effects

To reduce the risk of adverse reactions from Tessalon Perles, follow these important guidelines:

  • Swallow the Capsule Whole: Never chew, crush, suck, or dissolve the capsules.
  • Follow Healthcare Provider's Instructions: Take only the prescribed amount at the recommended intervals.
  • Avoid Interactions: Tell your doctor about all other medications, supplements, and herbal products you are taking. Be especially cautious with other CNS depressants.
  • Exercise Caution with Activities: Avoid driving or operating machinery until you know how the medication affects your alertness.
  • Keep Away from Children: Store the medication in a childproof container and keep it out of reach of children at all times.
  • Consult a Doctor for Persistent Cough: If your cough does not improve within seven days, or if you have a fever or rash, contact your doctor as it may indicate another medical issue.

Conclusion

While Tessalon Perles (benzonatate) is an effective prescription cough suppressant, understanding its side effects is crucial for safe use. Most users experience only mild, common side effects like drowsiness and headache. However, the most severe and potentially fatal risks are associated with chewing or sucking the capsule, or with accidental ingestion by children. By following your doctor's instructions, swallowing the capsule whole, and keeping the medication out of reach of children, you can significantly mitigate these serious dangers and use Tessalon Perles safely to manage your cough symptoms.

Frequently Asked Questions

The most common side effects of Tessalon Perles include drowsiness, dizziness, headache, nausea, and constipation.

If you chew or suck on a capsule, do not eat or drink until the numbness in your mouth and throat has fully resolved. Seek immediate medical attention if you experience difficulty breathing, a choking sensation, or if symptoms worsen.

No, Tessalon Perles is not recommended for children under 10 years old. Accidental ingestion, even of a small number of capsules, has been fatal in children.

The effects of Tessalon Perles typically last for 3 to 8 hours after taking a capsule.

Signs of an overdose can appear within 15-20 minutes and include restlessness, tremors, seizures, coma, and cardiac arrest. If an overdose is suspected, seek emergency medical help immediately.

It is important to inform your doctor about all other medications you take, as Tessalon Perles can interact with drugs that cause drowsiness, such as opioids or sedatives, and can worsen sedative effects.

Tessalon Perles should be stored in a sealed, child-resistant container at room temperature, away from heat, light, and humidity, and out of reach of children at all times.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.