Onyda XR is an extended-release oral suspension of clonidine hydrochloride used as a non-stimulant treatment for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6 and older. It works by affecting alpha-2 adrenergic receptors in the brain to help improve ADHD symptoms. Patients and caregivers should be aware of potential side effects.
Common Side Effects of Onyda XR
Common side effects often involve the central nervous system and digestive system. These may include drowsiness, fatigue, irritability, dry mouth, constipation, nightmares, sleep issues, reduced appetite, and dizziness.
Less Common and Rare Adverse Reactions
Less frequent effects can include nausea, vomiting, stomach pain, depression, anxiety, confusion, hallucinations, rash, itching, dry or burning eyes, blurred vision, or reduced sexual ability or desire in older patients.
Serious Warnings and Precautions
Onyda XR carries several serious risks requiring close monitoring. It can lower blood pressure and heart rate, which is a concern for those with heart problems or those taking other blood pressure medications. Abruptly stopping Onyda XR can cause a dangerous increase in blood pressure; discontinuation should be gradual under medical guidance. Clonidine can worsen heart rhythm problems and, rarely, cause a serious slowing of heart rate, especially with other heart medications. It may also impact fertility in both men and women. Seek immediate medical attention for severe allergic reactions like swelling of the face, lips, or tongue.
Side Effect Comparison: Monotherapy vs. Adjunctive Therapy
Clinical trial data shows some differences in side effects when Onyda XR is used alone versus with a stimulant. For example, Somnolence/Sedation, Fatigue, Irritability, Nightmares, Insomnia, Constipation, Dry Mouth, Decreased Appetite, and Dizziness were reported at varying frequencies in monotherapy and adjunctive therapy groups.
How to Manage Side Effects
Strategies exist to manage common side effects. For drowsiness and dizziness, taking medication at bedtime may help, and avoiding activities needing alertness is advised. Standing up slowly can help with dizziness. Dry mouth can be managed with sugarless gum or candy and staying hydrated. For constipation, increasing fiber and fluids, and exercising can be beneficial. Monitor blood pressure and heart rate for heart issues and report significant changes to a doctor.
Conclusion
Onyda XR is an FDA-approved non-stimulant for pediatric ADHD. Common side effects include drowsiness, fatigue, irritability, dry mouth, and constipation. Serious risks involve low blood pressure, slow heart rate, rebound hypertension if stopped suddenly, and potential fertility impact. Monitoring and management with a healthcare provider are key. Do not stop the medication suddenly and report any worrying symptoms. Additional prescribing information can be found on {Link: Tris Pharma https://www.trispharma.com/tris-pharma-receives-u-s-fda-approval-for-once-daily-onyda-xr-clonidine-hydrochloride-extended-release-oral-suspension-the-first-and-only-liquid-non-stimulant-adhd-medication/}.
Disclaimer: This content is for informational use and not a substitute for medical advice. Always consult a healthcare professional for diagnosis and treatment.
