What Color is FDA-Approved Semaglutide?
For FDA-approved injectable semaglutide, such as the brand names Ozempic and Wegovy, the solution should always be clear and colorless. Its appearance can be compared to that of water, though it might be slightly more viscous. This translucent liquid is a critical visual sign that the medication is safe and potent for use. Before administering an injection, patients should always inspect the solution through the pen's window. If the liquid is anything other than clear and colorless, or if it contains any floating particles, it must not be used.
What About Compounded Semaglutide and Color Variations?
Compounded semaglutide is a custom-made version of the medication prepared by licensed compounding pharmacies. Unlike the standardized FDA-approved pens, the appearance of compounded semaglutide can vary. The most common reason for a color variation is the addition of other ingredients, particularly vitamin B12, which is naturally red. If a compounding pharmacy combines semaglutide with B12, the resulting liquid can be pink or red.
However, it is crucial to confirm with the pharmacy or your healthcare provider that the formulation is intended to contain B12. A pink or red compounded solution that is not labeled to include vitamin B12 should be regarded with suspicion. Furthermore, any signs of cloudiness, milkiness, or discoloration (such as yellowing or browning) in a compounded solution that was initially clear indicate a potential problem. These changes could be due to improper storage, contamination, or degradation and mean the medication is no longer safe to use.
Why Color is a Critical Safety Indicator
The color of semaglutide serves as a vital indicator of its integrity and safety. For both branded and compounded versions, any unexpected change can be a warning sign. The stability of semaglutide can be compromised by several factors, including exposure to heat, light, or freezing temperatures. Improper storage can break down the molecular structure of the drug, making it less effective or potentially harmful. By visually inspecting your medication before each use, you can help protect yourself from using a compromised product. This is especially important for compounded versions, which are not subject to the same strict manufacturing standards as FDA-approved drugs and carry an increased risk of inconsistencies.
Comparing Semaglutide Formulations
| Feature | FDA-Approved (Ozempic, Wegovy) | Compounded Semaglutide | Oral Semaglutide (Rybelsus) |
|---|---|---|---|
| Appearance | Clear and colorless liquid | Typically clear and colorless, but can be pink or red if mixed with B12 | Oral tablets, usually pale yellow and imprinted with 'S' and dosage |
| Particles | Must be free of particles | Should be free of particles; presence is a sign of degradation | Not applicable |
| FDA Approval | Fully FDA-approved | Not FDA-approved; prepared by compounding pharmacies | Fully FDA-approved as a tablet |
| Safety Check | Check for clarity, absence of color, and no particles before every injection | Requires confirmation from the dispensing pharmacy about ingredients if colored | Verify correct pill color and imprint before taking |
| Risk of Contamination | Very low due to regulated manufacturing | Higher risk due to individualized preparation process | N/A, but check for pill damage |
The Importance of Proper Storage
To maintain the intended color, consistency, and effectiveness of semaglutide, proper storage is non-negotiable. For injectable formulations like Ozempic and Wegovy, unopened pens must be kept in the refrigerator at temperatures between 36°F and 46°F (2°C to 8°C). Once opened, Ozempic can be stored at room temperature for up to 56 days, while Wegovy can be kept at room temperature for up to 28 days. It is essential to never freeze the medication, as this can destroy its potency.
For compounded semaglutide, storage guidelines may vary by pharmacy, but typically require refrigeration. Oral semaglutide (Rybelsus) does not need refrigeration and should be stored at room temperature in a dry location, protected from moisture. All forms of semaglutide should be kept away from direct sunlight and excessive heat. If you suspect your medication has been stored improperly, check for any visual changes and consult your pharmacist or healthcare provider.
What to Do if You Spot a Color Change
If you notice that your semaglutide injection is cloudy, discolored, or contains solid particles, do not use it. Even if it's a compounded version that was previously clear, a color change is a sign of degradation or contamination. Discard the compromised medication safely, following your healthcare provider's or pharmacist's instructions for disposal. Contact your healthcare provider and the dispensing pharmacy immediately to report the issue and obtain a replacement. Taking a compromised medication can result in reduced effectiveness or unexpected side effects. Always prioritize your safety by performing a quick visual inspection before each injection.
Conclusion
Understanding what color semaglutide injection should be is a crucial step in ensuring the safety and efficacy of your medication. FDA-approved versions are strictly clear and colorless. While compounded versions may vary, especially if mixed with vitamin B12, any unexpected discoloration, cloudiness, or particles are significant red flags. Always verify your medication's correct appearance with a healthcare provider and follow strict storage guidelines to preserve its integrity. A simple visual inspection can be the most effective way to protect your health and confirm your medication is safe to use. If you are ever in doubt about your semaglutide’s appearance, contact your healthcare provider for guidance.
