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What do doctors prescribe to stop vaping? Key medications for cessation

4 min read

According to a 2025 study in the journal JAMA, the smoking cessation drug varenicline has shown significant effectiveness in helping young adults quit nicotine vaping. While there is no single FDA-approved medication specifically for e-cigarettes, doctors often prescribe medications and Nicotine Replacement Therapy to manage cravings and withdrawal symptoms.

Quick Summary

Doctors use a range of medications, including varenicline, bupropion, and various Nicotine Replacement Therapy products, to aid individuals in quitting vaping. These treatments help reduce cravings and withdrawal symptoms. The combination of medication with behavioral support often yields the best results for effective cessation.

Key Points

  • Consult a Doctor: A healthcare provider can help develop a personalized vaping cessation plan, often using medications originally approved for smoking cessation.

  • Varenicline: This prescription medication helps individuals stop vaping by reducing cravings and making nicotine less rewarding, and it has shown effectiveness in recent studies.

  • Bupropion: An antidepressant that can be prescribed to reduce nicotine withdrawal symptoms and cravings, and it is a non-nicotine medication option.

  • Nicotine Replacement Therapy (NRT): Available in various forms like patches, gum, and lozenges, NRT helps manage withdrawal by providing regulated doses of nicotine.

  • Combination Therapy: Combining long-acting NRT with a short-acting form, or combining medication like bupropion with NRT, can increase the chances of quitting successfully.

  • Behavioral Support is Key: Counseling and other support services are vital alongside medication to address psychological triggers and develop coping strategies.

In This Article

Understanding the Medical Approach to Vaping Cessation

Quitting vaping can be challenging due to the addictive nature of nicotine. While there are no medications specifically approved by the Food and Drug Administration (FDA) for vaping cessation, doctors regularly and effectively use medications approved for smoking cessation. A key component of successful treatment involves managing nicotine addiction and withdrawal symptoms, and medical professionals can tailor a plan that includes prescription medications, nicotine replacement therapy (NRT), or a combination of both. For many, combining medication with behavioral counseling offers the highest chance of success. Consulting a doctor is a crucial first step toward developing a personalized and effective quit strategy.

Primary Prescription Medications for Vaping Cessation

Medical doctors may prescribe certain medications to assist individuals who want to quit vaping. These non-nicotine pills work on the brain's neurochemistry to alleviate cravings and reduce withdrawal severity.

Varenicline (formerly Chantix)

Varenicline is considered one of the most effective single-product quitting aids available. Recent research specifically targeting young adults who vape has shown that varenicline, when combined with behavioral counseling, significantly improves abstinence rates. It works in two ways:

  • Blocks Nicotine Receptors: Varenicline binds to and blocks the same brain receptors that nicotine targets. If a person vapes while on the medication, the nicotine cannot produce the same satisfying effect, making the habit less rewarding.
  • Reduces Withdrawal: By partially stimulating the nicotine receptors, varenicline helps to reduce cravings and other withdrawal symptoms.

Potential side effects of varenicline include nausea, vivid dreams, constipation, and gas.

Bupropion (Wellbutrin, Zyban)

Bupropion is an antidepressant that is also effective in helping people quit smoking and is prescribed off-label for vaping cessation. It does not contain nicotine and is thought to reduce cravings and other withdrawal symptoms by blocking the reuptake of dopamine and norepinephrine.

  • How to Take It: It is typically started one to two weeks before a designated quit date. It is available in a sustained-release (SR) formulation.
  • Precautions: Bupropion can lower the seizure threshold and should not be used by those with a history of seizures or eating disorders. Common side effects can include insomnia, dry mouth, and mild tremors.

Nicotine Replacement Therapy (NRT)

Nicotine Replacement Therapy (NRT) is a common first-line treatment for nicotine addiction, and it can be highly beneficial for those quitting vaping. NRT provides the body with a controlled amount of nicotine to ease withdrawal symptoms and cravings, without the other harmful chemicals found in e-cigarettes. NRT is available in several forms, which can be used individually or in combination:

  • Patches: Provide a steady dose of nicotine through the skin over a 24-hour period, helping to manage baseline cravings.
  • Gum and Lozenges: Short-acting forms that can be used to manage breakthrough cravings or intense urges to vape.
  • Inhalers and Nasal Sprays: These are prescription-only NRT products that deliver nicotine more quickly than patches, gum, or lozenges, offering fast relief for cravings.

High-dose vapers, who may have consumed more nicotine than traditional smokers, may require higher doses of NRT to effectively manage their withdrawal symptoms.

Comparison of Vaping Cessation Medications

Medication/Therapy Form Primary Action Prescription Required Benefits for Vaping Cessation Potential Side Effects
Varenicline Oral tablet Blocks pleasure from nicotine, reduces cravings and withdrawal Yes High efficacy, recently supported for youth vaping cessation Nausea, vivid dreams, headache, constipation
Bupropion Oral tablet Reduces cravings and withdrawal symptoms Yes Non-nicotine option, can be used with NRT Insomnia, dry mouth, mild tremors, seizures (rare)
NRT Patches, gum, lozenges, inhalers, nasal spray Replaces nicotine to ease withdrawal and cravings OTC and prescription Available in various forms, can be combined for comprehensive coverage Local skin irritation (patch), jaw pain (gum), headache, stomach upset

The Role of Behavioral Support and Combination Therapy

Medication is most effective when used in conjunction with behavioral support. Counseling helps individuals explore the reasons behind their vaping habit, identify triggers, and develop coping strategies for managing cravings and stressful situations. Support is available through various channels:

  • Quitlines: National and state-specific quitlines (e.g., 1-800-QUIT-NOW) offer free, confidential counseling from trained coaches.
  • Support Groups: Connecting with others who are quitting can provide accountability and motivation.
  • Apps and Digital Programs: Apps like quitSTART and services like SmokefreeTXT offer tools and text-based support.

For those with intense nicotine dependence, a doctor may recommend combination therapy, such as using a nicotine patch for long-acting relief while using gum or lozenges for immediate cravings. Combining bupropion with NRT is another effective option.

Emerging Treatments

Research is ongoing to find new and more effective treatments. A recent clinical trial showed that cytisinicline, a plant-based medication, was more effective than a placebo at helping adults quit vaping when combined with behavioral support. As research continues, new options may become available in the future.

Conclusion

Quitting vaping is a significant health goal, and a doctor can provide the guidance and medical support necessary for a successful attempt. By utilizing medications like varenicline or bupropion and various forms of Nicotine Replacement Therapy, a personalized treatment plan can be developed to manage withdrawal and cravings. This medical approach, combined with robust behavioral support, gives individuals the best possible chance to overcome nicotine addiction and lead a vape-free life. It is crucial to consult a healthcare provider to determine the most suitable medical strategy for your specific needs, particularly given that current medications are used off-label for vaping based on their success with smoking cessation. For more resources and support, visit the CDC's Smoking and Tobacco Use website for a range of tools.(https://www.cdc.gov/tobacco/e-cigarettes/quitting.html)

Frequently Asked Questions

Currently, there are no medications approved by the FDA specifically for vaping cessation. However, doctors routinely prescribe medications approved for smoking cessation, like varenicline and bupropion, to help individuals quit vaping due to the similar nature of nicotine addiction.

Varenicline helps by acting on nicotine receptors in the brain. It partially stimulates these receptors to reduce cravings and withdrawal symptoms, while also blocking nicotine from binding, which makes vaping less pleasurable.

Yes, NRT products like patches, gum, and lozenges can be used to help quit vaping. They work by delivering controlled doses of nicotine to ease withdrawal symptoms and cravings, without the other chemicals found in vapes.

Common side effects of bupropion can include insomnia and dry mouth. More serious side effects, such as seizures, are rare, and the medication is contraindicated in individuals with a history of seizure disorders or eating disorders.

Yes, for many people with strong nicotine dependence, a combination of treatments is more effective. This could involve combining a long-acting NRT with a short-acting one, or using a prescription medication alongside NRT.

Yes, combining medication with behavioral counseling significantly increases the chances of quitting successfully. Counseling helps address the psychological aspects of addiction, such as identifying triggers and developing coping mechanisms.

When you talk to your doctor, be open and honest about your vaping habits, including how often you vape, the nicotine strength you use, and your motivation to quit. This information helps them create the most effective and personalized plan for you.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.