What does PROLENSA do to your eyes? A detailed look at its post-cataract effects

In clinical trials, nearly 4 out of 5 patients using PROLENSA reported being pain-free just one day after cataract surgery. This prescription eye drop is an important part of postoperative care, but many people are curious about the specifics of what does PROLENSA do to your eyes. It works on a molecular level to combat the pain and swelling that naturally occur following ophthalmic procedures.

Quick Summary

PROLENSA is a prescription ophthalmic solution containing the nonsteroidal anti-inflammatory drug (NSAID) bromfenac. It works by inhibiting prostaglandin synthesis to manage pain and inflammation in the eyes following cataract surgery, typically used for up to two weeks postoperatively.

Key Points

• Reduces Post-Surgical Inflammation: PROLENSA is an NSAID that reduces swelling and inflammation in the eye following cataract surgery.

• Relieves Ocular Pain: It provides effective relief from eye pain, aiding in a more comfortable recovery period.

• Works by Inhibiting Prostaglandins: The medication functions by blocking the COX enzymes responsible for producing prostaglandins, the compounds that cause inflammation and pain.

• Requires Specific Usage: It is typically applied as a once-daily drop for about two weeks, with specific steps to ensure sterility and proper absorption.

• May Have Side Effects: Common side effects include blurred vision, eye pain, and light sensitivity. Serious corneal issues are possible with long-term use.

• Contains Sulfites: The presence of sodium sulfite means individuals with sulfite allergies, particularly asthmatics, should use caution.

How PROLENSA Works: The Science of Pain Relief

PROLENSA (bromfenac ophthalmic solution) is a nonsteroidal anti-inflammatory drug (NSAID) used topically in the eye. Post-cataract surgery, eyes can become inflamed due to tissue trauma, leading to pain and swelling caused by prostaglandins.

The active ingredient, bromfenac, inhibits cyclooxygenase (COX) enzymes (COX-1 and COX-2), which are necessary for prostaglandin production. By blocking these enzymes, PROLENSA stops the inflammatory process and reduces prostaglandins in ocular tissues. This approach offers localized pain and inflammation relief with less systemic exposure than oral NSAIDs.

Therapeutic Benefits After Cataract Surgery

PROLENSA helps manage inflammation, leading to:

• Reduction of Inflammation: It has been shown to significantly decrease anterior chamber inflammation after surgery.
• Pain Reduction: PROLENSA effectively reduces eye pain, promoting a more comfortable recovery.
• Symptom Management: It alleviates symptoms like redness, irritation, and light sensitivity.

Using PROLENSA Safely and Effectively

Your doctor will provide specific usage instructions. A typical regimen is one drop daily in the affected eye, starting a day before surgery and continuing for 14 days afterward. Proper administration is key.

Step-by-Step Administration Guide

1. Wash hands thoroughly.
2. Gently shake the bottle.
3. Tilt head back and pull down the lower eyelid to form a pocket.
4. Administer one drop into the pocket without touching the eye.
5. Close the eye for one to two minutes; avoid blinking or squeezing.
6. Press the tear duct in the inner corner of the eye gently.
7. Remove contact lenses before use and wait at least 10 minutes before reinserting.
8. If using other eye drops, wait at least five minutes between medications.

Potential Side Effects and Risks

PROLENSA is usually well-tolerated, but side effects can occur. Common ones (3% to 8% of patients) include anterior chamber inflammation, foreign body sensation, eye pain, blurred vision, and light sensitivity.

Rare but more serious side effects may occur, especially with extended use or in high-risk individuals:

• Corneal Reactions: Prolonged NSAID use can lead to keratitis, thinning, erosion, ulceration, or perforation of the cornea. Risks are higher for patients with diabetes, dry eyes, or complex surgeries.
• Delayed Healing: NSAIDs might slow healing, particularly when used with topical corticosteroids.
• Allergic Reactions: PROLENSA contains sodium sulfite, which can trigger allergic responses in sensitive people, including asthmatics.
• Increased Bleeding Risk: Ocular NSAIDs can increase bleeding risk in eye tissues, caution is advised for those with bleeding tendencies or on blood thinners.

Comparing PROLENSA to Other NSAID Eye Drops

Other NSAID eye drops are used post-cataract surgery, such as nepafenac (Nevanac). Here is a comparison:

Feature	PROLENSA (Bromfenac)	Nevanac (Nepafenac)
Dosing Frequency	Once daily, often for 14 days	Typically three times daily, for up to 14 days
Active Ingredient	Bromfenac (0.07%)	Nepafenac (0.1%)
Target Population	Adults only	Adults and children age 10 and older
Side Effects	Blurred vision, light sensitivity, foreign body sensation, eye pain	Decreased visual clarity, feeling something in the eye
Special Consideration	Contains sodium sulfite (potential allergen)	Does not contain sulfites, approved for a broader age range
pH	Closer to neutral tears (7.8)	Less neutral

This information is for comparison only. A healthcare professional should make medication decisions based on individual needs. Consult the manufacturer or FDA for specific product details.

Conclusion

In conclusion, what does PROLENSA do to your eyes? It provides localized pain and inflammation relief after cataract surgery by inhibiting prostaglandin production via its active ingredient, bromfenac. This helps reduce discomfort and other symptoms, aiding recovery. Proper use and awareness of potential side effects, particularly concerning the cornea and allergic reactions, are vital. Always follow your ophthalmologist's guidance and report any unusual symptoms for a successful recovery. PROLENSA's efficacy and once-daily dosing make it a valuable option in ophthalmic care.

For more information on post-cataract surgery care, consider visiting the official Prolensa patient website for educational materials and important safety information.

Frequently Asked Questions

What is the primary purpose of PROLENSA eye drops?

The primary purpose of PROLENSA is to treat inflammation and reduce ocular pain in patients who have undergone cataract surgery.

How often do I need to use PROLENSA?

PROLENSA is typically applied as one drop to the affected eye once daily, beginning one day before surgery and continuing for 14 days after.

Can I wear my contact lenses while using PROLENSA?

No, you should remove your contact lenses before using PROLENSA. The preservative in the drops can be absorbed by soft lenses. You can reinsert them after waiting at least 10 minutes.

What should I do if I experience blurred vision after using PROLENSA?

Blurred vision is a possible, and sometimes temporary, side effect of PROLENSA. Wait several minutes for your vision to clear before driving or operating machinery. If vision changes persist or worsen, contact your eye doctor.

Is PROLENSA safe for long-term use?

No, PROLENSA is not intended for long-term use. Prolonged use of NSAID eye drops can increase the risk of serious side effects, such as corneal problems.

What is the difference between PROLENSA and steroid eye drops?

PROLENSA is an NSAID, which targets and inhibits prostaglandins to reduce inflammation. Steroid eye drops, often used in combination with NSAIDs, act at a different point in the inflammatory pathway. Your doctor will determine the right combination for your specific needs.

Are there any serious risks associated with using PROLENSA?

While uncommon, serious risks include sight-threatening corneal reactions, delayed healing, and increased bleeding time. Individuals with certain conditions like diabetes or rheumatoid arthritis are at higher risk. Discuss your medical history with your doctor.