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What happens when you stop taking your Vyvanse? A Guide to Withdrawal

4 min read

In one study, treatment failure occurred in 67.5% of adult ADHD patients who stopped Vyvanse and took a placebo [1.8.1]. This highlights the significant impact of discontinuation. So, what happens when you stop taking your Vyvanse, and how can the process be managed safely?

Quick Summary

Stopping Vyvanse (lisdexamfetamine) can lead to withdrawal symptoms like fatigue, depression, and intense cravings. The process should be medically supervised to minimize discomfort and ensure safety.

Key Points

  • Medical Supervision is Crucial: Never stop taking Vyvanse abruptly or without a doctor's guidance; a gradual tapering plan is the safest method [1.4.5].

  • Withdrawal vs. Crash: A 'crash' is a short-term daily effect, while withdrawal is a longer process of discontinuation with more severe symptoms like depression and intense cravings [1.2.1].

  • Symptoms are Physical and Psychological: Expect symptoms ranging from extreme fatigue, increased appetite, and headaches to anxiety, depression, and mood swings [1.2.1, 1.2.2].

  • Timeline Varies: Symptoms typically begin 1-2 days after the last dose, peak within the first week, and can last for several weeks or even months [1.9.3, 1.2.1].

  • Return of Original Symptoms: Be prepared for the possible return or worsening of ADHD or Binge Eating Disorder symptoms once the medication is stopped [1.9.3, 1.4.4].

  • Severe Symptoms Require Immediate Help: Seek immediate medical attention for severe symptoms like suicidal thoughts, hallucinations, or extreme depression [1.2.1, 1.9.5].

  • Lifestyle Choices aid Recovery: A healthy diet, regular exercise, consistent sleep, and staying hydrated can help ease physical symptoms and support overall well-being [1.2.1, 1.7.1].

In This Article

Understanding Vyvanse and Why People Stop Taking It

Vyvanse, the brand name for lisdexamfetamine, is a central nervous system stimulant prescribed for Attention-Deficit/Hyperactivity Disorder (ADHD) and moderate to severe Binge Eating Disorder (BED) in adults [1.4.5, 1.2.6]. It works by increasing levels of norepinephrine and dopamine in the brain, which helps improve focus, decrease impulsivity, and control hyperactivity [1.2.2].

People may decide to stop taking Vyvanse for various reasons. These can include unpleasant side effects like anxiety, insomnia, or loss of appetite [1.2.2]. Other reasons might be a desire to manage their condition without medication, concerns about long-term use and dependence, or simply a planned 'drug holiday' to assess the continued need for the medication, often under a doctor's guidance [1.2.5, 1.2.2]. Regardless of the reason, stopping the medication requires careful consideration and planning because the body and brain have adapted to its presence [1.2.1].

The Dangers of Stopping Cold Turkey

Quitting Vyvanse "cold turkey," or abruptly, is generally not recommended and can be dangerous, especially for those on high doses or who have used the medication for a long time [1.2.1, 1.2.2]. A sudden stop can trigger a "crash" and more severe withdrawal symptoms because it shocks the system, which has come to rely on the drug to maintain its neurochemical balance [1.4.4, 1.2.2]. This can lead to intense fatigue, severe depression, and strong cravings, increasing the risk of relapse [1.9.3, 1.2.1]. For individuals with BED, abrupt cessation can also lead to a relapse of binge eating behaviors [1.7.5]. It is crucial to consult a healthcare provider to create a tapering plan, which involves gradually reducing the dosage over weeks or months [1.4.3]. This allows the body to adjust slowly, minimizing the severity of withdrawal symptoms [1.4.5].

Vyvanse Withdrawal vs. Crash: A Comparison

It's common to confuse a "Vyvanse crash" with withdrawal, but they are different experiences [1.2.1]. A crash is a short-term effect that can happen as a daily dose wears off, while withdrawal is a longer process that occurs after discontinuing the medication following consistent use [1.2.1, 1.6.3].

Feature Vyvanse Crash Vyvanse Withdrawal
Onset Occurs the same day, as the medication's effects diminish [1.2.1]. Begins 1-2 days after the last dose is taken [1.2.1].
Duration Typically lasts for only a few hours [1.2.1]. Can last from several days to multiple weeks or even months [1.2.1, 1.9.3].
Cause A daily drop in medication levels in the bloodstream [1.6.1]. Discontinuation or significant reduction of the drug after prolonged use [1.2.1].
Symptoms Milder symptoms such as fatigue, irritability, and brain fog [1.2.1, 1.6.3]. More intense symptoms including extreme fatigue, depression, anxiety, body aches, and strong cravings [1.2.1].

Common Withdrawal Symptoms and Timeline

When you stop taking Vyvanse, your brain's dopamine and norepinephrine levels drop suddenly, leading to a range of physical and psychological symptoms as your body readjusts [1.2.1]. The severity and duration depend on factors like dosage, duration of use, and individual physiology [1.2.1].

Common Symptoms

  • Psychological: Depression, anxiety, irritability, mood swings, trouble concentrating, anhedonia (inability to feel pleasure), and intense cravings for the medication [1.2.1, 1.2.2, 1.2.5]. In rare, severe cases, symptoms can include paranoia, psychosis, hallucinations, or suicidal thoughts, which require immediate medical attention [1.9.5, 1.2.1].
  • Physical: Extreme fatigue, changes in sleep patterns (insomnia or hypersomnia), increased appetite, headaches, body aches, sweating, and shakiness [1.2.1, 1.2.2].

General Withdrawal Timeline

  • Days 1-2: The initial "crash" period often begins. Symptoms include fatigue, low mood, headaches, and the start of cravings [1.9.3, 1.2.1].
  • Days 3-7: Symptoms typically peak in intensity during this period. This is when depression, anxiety, irritability, exhaustion, and strong cravings are most severe [1.9.3, 1.2.1].
  • Weeks 2-4: Physical symptoms gradually begin to subside. Energy levels and mood start to improve, but psychological symptoms like cravings, anxiety, and depression may linger [1.9.3, 1.2.1].
  • Month 2+: Most acute symptoms have faded for many people. However, some may experience Post-Acute Withdrawal Syndrome (PAWS), where symptoms like mood swings, anxiety, and sleep disturbances persist for weeks or months [1.9.5, 1.9.3].

How to Manage Vyvanse Withdrawal Safely

Managing withdrawal effectively requires a comprehensive approach focused on safety and well-being. The most crucial step is to seek medical supervision [1.4.1].

Professional Medical Guidance

  • Tapering Plan: A doctor is essential for creating a personalized tapering schedule. This gradual dose reduction is the safest way to discontinue Vyvanse, minimizing the shock to your system [1.4.5].
  • Monitoring: Regular check-ins with a healthcare provider help monitor for severe symptoms like deep depression or suicidal thoughts, ensuring prompt intervention if needed [1.2.1].
  • Therapy: Cognitive-behavioral therapy (CBT) and other forms of counseling can help develop coping strategies for managing cravings, emotional triggers, and the return of underlying ADHD or BED symptoms [1.4.2, 1.7.4].

At-Home Strategies and Support

  • Lifestyle: Prioritize a consistent sleep schedule, stay hydrated, and eat a balanced diet to support your body's recovery [1.2.1, 1.7.1].
  • Exercise: Regular physical activity can help boost your mood and reduce stress [1.7.1].
  • Relaxation: Practices like mindfulness, meditation, or creative therapies can promote emotional stability [1.2.1, 1.7.4].
  • Support System: Joining support groups or informing friends and family can provide a valuable network for accountability and emotional support during the process [1.4.2, 1.4.3].

Conclusion

Stopping Vyvanse is a significant medical decision that initiates a complex withdrawal process. Understanding the difference between a temporary 'crash' and a full withdrawal, recognizing the potential symptoms, and knowing the general timeline can prepare you for the experience. The most critical factor for a safe and successful discontinuation is doing so under the direct supervision of a healthcare professional who can provide a tapering plan and necessary support. Combining medical guidance with healthy lifestyle choices and a strong support system offers the best path toward managing withdrawal and achieving long-term well-being.

For more detailed information, you can visit the FDA's official page for Vyvanse.

Frequently Asked Questions

Most acute withdrawal symptoms significantly improve within 1-2 weeks, but some emotional effects like low mood and cravings can last for several weeks or even months [1.2.1, 1.9.3].

Quitting Vyvanse cold turkey can cause a sudden drop in brain chemicals, leading to intense withdrawal symptoms such as severe fatigue, depression, and strong cravings, which increases the risk of relapse [1.2.1, 1.2.2].

Yes, it is strongly recommended to wean off Vyvanse gradually. A doctor will create a tapering schedule to slowly lower the dose, which allows your body to adjust and minimizes the severity of withdrawal symptoms [1.4.5, 1.2.1].

Extreme fatigue is one of the most common withdrawal symptoms. It occurs because your body has adapted to the stimulating effects of the medication, and your brain needs time to readjust its natural energy and dopamine levels [1.2.1].

Yes, it is very likely that your original ADHD or Binge Eating Disorder symptoms will return after you stop taking Vyvanse. It is important to discuss alternative treatments, such as non-stimulant medications or behavioral therapy, with your doctor [1.9.3, 1.4.4].

While some people take 'drug holidays' on weekends under medical advice, it can trigger withdrawal symptoms like fatigue and irritability for others. You should always discuss this with your healthcare provider before changing your dosing schedule [1.2.1].

While typically not life-threatening, Vyvanse withdrawal can be dangerous due to the risk of severe depression and suicidal thoughts. Medical supervision is essential to manage these psychological risks safely [1.9.5, 1.9.3].

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.