Identifying the Pink Pill with 'e343'
According to established pharmaceutical databases, the pink, oval pill with the imprint 'e343' is Amphetamine and Dextroamphetamine 15 mg. This medication is a combination of two central nervous system (CNS) stimulants, primarily used for the management of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. The manufacturer of this particular generic version is listed as Sun Pharmaceutical Industries, Inc., which holds an abbreviated new drug application (ANDA) for the product.
What are Amphetamine and Dextroamphetamine?
This combination medication contains a 3:1 ratio of the dextro isomer and levo isomer of amphetamine salts, which includes dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate. These active ingredients work by affecting key neurotransmitters in the brain:
- Dopamine: A neurotransmitter involved in reward, motivation, and motor control. The medication increases dopamine levels, which can help improve focus and attention.
- Norepinephrine: A neurotransmitter that affects alertness, arousal, and attention. Amphetamine and dextroamphetamine increase its release and block its reuptake, contributing to the stimulant effects.
By modulating these brain chemicals, the medication helps to increase attention span, concentration, and reduce impulsivity and hyperactivity in patients with ADHD. It also helps counteract the excessive daytime sleepiness associated with narcolepsy.
Understanding the Controlled Substance Classification
Amphetamine and Dextroamphetamine is classified by the DEA as a Schedule II controlled substance. This classification is significant and comes with strict regulations due to the high potential for abuse, misuse, and addiction. Patients and caregivers must be aware of the following risks:
- Addiction and Dependence: Prolonged use can lead to physical dependence, and abrupt cessation can cause withdrawal symptoms, such as severe depression and fatigue.
- Misuse and Diversion: The drug can be misused for non-medical purposes. Prescriptions are non-refillable and require regular follow-ups with a healthcare provider.
- Safe Storage: Due to its abuse potential, the medication must be stored securely, ideally in a locked cabinet, and kept away from children and others.
Important Safety Considerations and Side Effects
Like all powerful medications, amphetamine and dextroamphetamine carry a risk of side effects, ranging from common to severe. Patients should be closely monitored by their healthcare provider throughout treatment.
Common Side Effects
- Decreased appetite and weight loss
- Dry mouth
- Nervousness or anxiety
- Insomnia or trouble sleeping
- Stomach pain, diarrhea, or constipation
- Headache
Serious Side Effects
- Cardiovascular Risks: Amphetamine can increase blood pressure and heart rate. It has been associated with sudden death in patients with pre-existing heart conditions. Any chest pain, shortness of breath, or fainting should prompt immediate medical attention.
- Mental Health Issues: The medication may cause new psychotic or manic symptoms, such as hallucinations or delusions, even in patients without a prior history.
- Serotonin Syndrome: A potentially life-threatening condition that can occur when this medication is taken with other serotonergic drugs. Symptoms include agitation, fast heart rate, fever, and confusion.
- Peripheral Vasculopathy: This condition affects blood flow to the fingers and toes, causing them to feel cold or appear discolored.
- Seizures: Stimulants may lower the convulsive threshold, increasing the risk of seizures.
Drug Interactions
Patients must inform their doctor about all medications and supplements they are taking to avoid dangerous interactions. Some key interactions include:
- MAOIs: Monoamine oxidase inhibitors should not be taken within 14 days of taking amphetamine due to the risk of hypertensive crisis.
- Serotonergic Drugs: Co-administration with SSRIs or SNRIs can increase the risk of serotonin syndrome.
- Acidifying and Alkalinizing Agents: Substances that change urine pH can alter the clearance of amphetamine, affecting its effectiveness or increasing side effects.
Generic vs. Brand-Name Amphetamine and Dextroamphetamine
While the pink pill with 'e343' is a generic version of amphetamine and dextroamphetamine, it is chemically equivalent to its brand-name counterparts. However, there are differences in dosage, delivery, and inactive ingredients.
| Feature | Generic Amphetamine/Dextroamphetamine (e343 pill) | Brand-Name Adderall (Immediate-Release) | Brand-Name Adderall XR (Extended-Release) |
|---|---|---|---|
| Manufacturer | Sun Pharmaceutical Industries, Inc. | Teva Pharmaceuticals | Takeda Pharmaceuticals |
| Dosage Form | Tablet (15 mg) | Tablet (various strengths) | Capsule (various strengths) |
| Mechanism | Immediate-release | Immediate-release | Extended-release |
| Administration | Taken 2-3 times daily | Taken 2-3 times daily | Taken once daily in the morning |
| Ingredients | Amphetamine salt combo (3:1 d- to l- isomer ratio). Inactive ingredients include lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, and D&C Red #27 Aluminum Lake. | Amphetamine salt combo (3:1 d- to l- isomer ratio). Inactive ingredients vary by manufacturer and dose. | Extended-release amphetamine salt combo. Inactive ingredients vary. |
Pediatric Use and Growth Concerns
For pediatric patients, amphetamine and dextroamphetamine are indicated for ADHD treatment, but the potential for long-term suppression of growth must be considered. Height and weight should be regularly monitored, and treatment may be temporarily interrupted if growth is not proceeding as expected. The FDA has issued safety communications about weight loss risks in younger children taking extended-release stimulants.
Conclusion: Prioritizing Patient Safety
Proper medication identification is a cornerstone of patient safety. The pink oval pill with 'e343' is a potent central nervous system stimulant used for ADHD and narcolepsy, and it must be handled with care due to its high abuse potential. Anyone who finds such a pill or has questions about their own medication should consult with a healthcare professional or a pharmacist. Due to the significant risks associated with misuse, abuse, and potential for severe side effects, this medication should only be taken exactly as prescribed and under medical supervision. Sharing this medication is illegal and can cause serious harm to others.
For more detailed information, consult the MedlinePlus entry for Dextroamphetamine and Amphetamine.
