What is Cypro B Plus used for? An In-depth Guide

October 6, 2025 •

4 min read

Cypro B Plus is a medication known for its synergistic combination of cyproheptadine and B vitamins, specifically formulated to stimulate appetite and increase body weight. A 2019 systematic review highlighted that cyproheptadine, a key ingredient, appears to be a safe and well-tolerated appetite stimulant for various underweight populations. The medication is commonly used to address conditions like poor appetite, eating disorders, and general weight loss.

Quick Summary

Cypro B Plus contains cyproheptadine and B vitamins, functioning primarily as an appetite stimulant and weight-gain aid. It works by targeting the body's metabolic activity, addressing poor appetite and weight loss. Its key active ingredient, cyproheptadine, is a well-documented appetite booster, and the B vitamins support overall metabolic health.

Key Points

Appetite Stimulation: Cypro B Plus is primarily used to stimulate appetite and promote weight gain in individuals with poor appetite or unintentional weight loss.
Key Ingredients: It contains cyproheptadine, a serotonin antagonist that boosts hunger, and B vitamins, which support metabolic activity.
Common Side Effects: The most common side effect is drowsiness, particularly during the initial days of treatment. Other side effects include dizziness, dry mouth, and weight gain.
Medical Supervision: Use, especially in children, should be strictly supervised by a doctor due to potential side effects and dosing considerations based on weight.
Contraindications: It is not safe for newborn or premature infants, nursing mothers, or individuals with conditions like glaucoma, asthma, or certain ulcer types.
Comparative Efficacy: While effective for appetite stimulation, it has a different mechanism and side effect profile compared to other appetite stimulants like dronabinol or megestrol.
Caution for Long-Term Use: Some reports suggest potential dependency or decreased effectiveness over time, and prolonged, unsupervised use is discouraged.
Avoid Alcohol and Machinery: Due to its sedative effects, users should avoid alcohol and operating heavy machinery until they know how the medication affects them.

What is Cypro B Plus?

Cypro B Plus is a medicinal supplement combining the appetite-stimulating effects of cyproheptadine hydrochloride with the metabolic benefits of B vitamins. It is most commonly available as a syrup or tablets and is primarily used to address issues related to poor appetite, unintentional weight loss, and certain eating disorders. The combination of ingredients aims to not only boost the user's desire for food but also support the body's general metabolic functions, ensuring that nutrients are properly processed and utilized.

The active ingredients

The effectiveness of Cypro B Plus is largely attributed to its two main components:

Cyproheptadine Hydrochloride: This is a first-generation antihistamine with a side effect of appetite stimulation. It is also a serotonin antagonist, meaning it blocks serotonin receptors in the brain's appetite center in the hypothalamus. This action is thought to be the primary mechanism by which it increases hunger and leads to weight gain.
B Vitamins (B-Complex): The specific B vitamins and their quantities can vary by brand and formulation, but typically include Thiamine (B1), Riboflavin (B2), Niacinamide (B3), Pyridoxine (B6), and Vitamin B12. These vitamins are crucial for converting food into energy and supporting the nervous system. By helping to regularize metabolic activity, they provide additional support during periods of increased calorie and nutrient intake.

Medical uses for Cypro B Plus

The primary use of Cypro B Plus is to stimulate appetite, but this application can be beneficial in several different scenarios:

Poor Appetite and Anorexia: For individuals struggling with a decreased or absent appetite due to various causes, such as chronic illness, recovery from surgery, or stress, Cypro B Plus can be an effective intervention.
Unintentional Weight Loss: When weight loss occurs without a clear cause, often alongside poor appetite, Cypro B Plus helps to reverse the trend by increasing food intake. User reviews from Drugs.com often praise the medication for its effectiveness in helping underweight individuals gain weight rapidly.
Failure to Thrive (in children): In some cases, Cypro B Plus is used under medical supervision for pediatric patients who are not gaining weight appropriately. It is crucial to note, however, that safety and effectiveness for very young children, especially those under two, have not been established and usage should be strictly controlled by a physician.
Eating Disorders: While not a standalone treatment for complex psychological conditions, it may be used as an adjunct to other therapies to help restore healthy eating patterns and promote weight restoration in certain eating disorders, especially when appetite loss is a significant factor.

Important considerations and potential side effects

While generally well-tolerated, Cypro B Plus can cause a number of side effects due to its cyproheptadine content. The most common of these is drowsiness, which is often transient and can decrease after the first few days of use.

Common side effects include:

Drowsiness or sleepiness
Dizziness
Dry mouth, nose, and throat
Increased appetite leading to weight gain
Nausea
Constipation

More serious side effects requiring immediate medical attention are rare but can occur:

Difficulty urinating
Vision problems
Confusion, nervousness, or restlessness
Rapid or irregular heartbeat

Contraindications and precautions

Certain individuals should not take Cypro B Plus, and others should do so with caution:

Contraindications: It should not be used in premature or newborn infants, nursing mothers, or individuals with hypersensitivity to its ingredients. It is also contraindicated for those with narrow-angle glaucoma, peptic ulcers, or blockages in the bladder or stomach.
Precautions: Caution is advised for individuals with a history of asthma, hyperthyroidism, cardiovascular disease, or high blood pressure. Due to potential drowsiness, users should avoid driving or operating heavy machinery until they understand how the medication affects them. Alcohol can intensify the sedative effects and should be avoided.

Comparison with other appetite stimulants

Cypro B Plus is not the only option for stimulating appetite. Below is a comparison with other common alternatives.


Feature	Cypro B Plus (Cyproheptadine + B Vitamins)	Dronabinol (e.g., Marinol)	Megestrol (e.g., Megace)
Mechanism	Antihistamine and serotonin antagonist; B vitamins aid metabolism.	Cannabinoid receptor agonist.	Progestin hormone, mechanism for appetite increase is not fully understood.
Key Use	Poor appetite, unintentional weight loss, eating disorders.	AIDS-related anorexia and weight loss.	Anorexia, cachexia (wasting syndrome) in AIDS patients.
Common Side Effects	Drowsiness, dizziness, dry mouth, weight gain.	Dizziness, euphoria, paranoia, sleepiness.	Weight gain, high blood pressure, fluid retention, blood clots.
Potential for Dependence	Some user reports suggest potential dependency, although not considered a controlled substance.	Controlled substance (Schedule II), potential for abuse and dependence.	Not a controlled substance; however, potential for serious cardiovascular and metabolic side effects exists.
Availability	Prescription only; availability and formulation may vary by region.	Prescription only; typically for specific medical conditions.	Prescription only; generally reserved for specific conditions.

How to take Cypro B Plus

Cypro B Plus is available as both tablets and syrup. Liquid formulations should always be measured with a proper measuring device, not a household spoon. It is essential to follow a healthcare provider's instructions and the product's packaging carefully.

Conclusion

Cypro B Plus serves as an effective appetite stimulant and weight-gain supplement for individuals experiencing poor appetite and unintended weight loss. Its dual-action formula, combining the potent appetite-boosting properties of cyproheptadine with the metabolic support of B vitamins, makes it a targeted treatment option. However, users must be aware of potential side effects, especially drowsiness, and adhere strictly to medical guidance. While many users report positive outcomes, especially concerning rapid weight gain, long-term use and use for cosmetic purposes should be approached with caution and under a doctor's supervision. It is important to weigh the benefits against the risks and consider the context of other available appetite-stimulating alternatives.

Disclaimer: The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult a healthcare professional before starting any new medication.

Frequently Asked Questions

Cypro B Plus is primarily used to stimulate appetite and promote weight gain. It is effective for individuals experiencing poor appetite, unintentional weight loss, or certain eating disorders.

The main active ingredients are cyproheptadine, an antihistamine and appetite stimulant, and a complex of B vitamins, which aid in metabolism.

Common side effects include drowsiness, dizziness, dry mouth, and increased appetite leading to weight gain. Drowsiness often lessens after the first few days of use.

It is not recommended to drive or operate heavy machinery until you are certain how the medication affects you, as it can cause significant drowsiness and impair alertness.

It can be used in children for 'Failure to Thrive' under strict medical supervision. However, it is not approved for use in infants younger than two years, and the dosage is based on body weight.

While it does promote weight gain, some users on platforms like Drugs.com have reported dependency and health issues after prolonged, unsupervised use for cosmetic purposes. It is always best to consult a doctor.

You should avoid alcohol, as it can intensify the sedative side effects. You should also inform your doctor about any other medications, especially MAO inhibitors or other CNS depressants.