A Luforbec inhaler is a prescription medication used to manage symptoms of chronic respiratory diseases, primarily asthma and chronic obstructive pulmonary disease (COPD). It is a combination therapy utilizing two active ingredients to address different aspects of these conditions.
The Active Ingredients
The two main active substances in a Luforbec inhaler are a corticosteroid and a long-acting beta2-agonist (LABA). They work together to reduce inflammation and relax airway muscles, making breathing easier.
Beclometasone Dipropionate: The Corticosteroid
This inhaled corticosteroid (ICS) acts as an anti-inflammatory agent, calming the immune response in the lungs. It helps reduce the swelling and irritation in the airways that cause symptoms like wheezing, shortness of breath, and coughing in conditions like asthma. Beclometasone prevents symptoms and reduces the frequency and severity of exacerbations over time. Its anti-inflammatory effect develops over time and is not for immediate relief of a sudden asthma attack. Beclometasone dipropionate is converted to an active metabolite with potent anti-inflammatory effects directly in the lungs.
Formoterol Fumarate Dihydrate: The Bronchodilator
Formoterol is a long-acting beta2-agonist (LABA) bronchodilator that relaxes the smooth muscles surrounding the airways. This action widens the airways, improving airflow in and out of the lungs. Its effect begins quickly, typically within 1-3 minutes, and lasts up to 12 hours. Formoterol stimulates beta2-adrenergic receptors on airway muscle cells, causing muscle relaxation and bronchodilation.
The Inactive Ingredients
Luforbec inhalers also contain inactive ingredients essential for delivery and stability:
- Ethanol anhydrous: Aids in the solubility and delivery of active ingredients.
- Maleic acid: Acts as a stabilizing agent.
- Norflurane (HFA-134a): The propellant that delivers the medicine. This is a more environmentally friendly alternative to older CFC propellants.
- Water for injections: Included to complete the solution.
Luforbec Formulations Comparison
Luforbec comes in different strengths, mainly varying in the beclometasone dose while the formoterol dose remains constant. The appropriate strength is determined by a healthcare professional based on the patient's condition severity.
| Feature | Luforbec 100/6 | Luforbec 200/6 |
|---|---|---|
| Beclometasone Dipropionate | 100 mcg per actuation | 200 mcg per actuation |
| Formoterol Fumarate Dihydrate | 6 mcg per actuation | 6 mcg per actuation |
| Indication for Asthma | Moderate to severe asthma not adequately controlled or well-controlled | Moderate to severe asthma not adequately controlled or well-controlled |
| Indication for COPD | Indicated for severe COPD | Not indicated for COPD treatment |
How the ingredients work together for treatment
Luforbec can be prescribed for asthma patients in two ways:
- Maintenance Therapy: Regular daily use with a separate reliever inhaler for sudden symptoms.
- Maintenance and Reliever Therapy (MART): Luforbec is used for both daily control and as a reliever for sudden symptoms.
For severe COPD, Luforbec is used for symptomatic treatment to reduce exacerbations.
The Importance of Administration
Luforbec is a metered-dose inhaler (pMDI) that delivers medicine as a fine mist. Correct inhalation technique is vital for effectiveness. To minimize the risk of oral thrush from inhaled steroids, rinsing the mouth with water or brushing teeth after use is recommended.
Conclusion
Understanding what's in a Luforbec inhaler highlights its function as a dual-action medication. It combines the anti-inflammatory power of beclometasone dipropionate with the bronchodilating effect of formoterol fumarate dihydrate. These active ingredients, along with necessary excipients and propellant, provide effective management for chronic respiratory conditions like asthma and severe COPD. Always follow your healthcare provider's instructions for optimal results and to reduce potential side effects. Consult the patient information leaflet or your doctor/pharmacist for more details.
