What is Iruxol mono pomada? A Complete Guide to Enzymatic Wound Debridement

With over 20 years of successful use in wound treatment, Iruxol mono pomada is a proven enzymatic ointment used for gentle and selective removal of necrotic tissue. This medication's active components work to cleanse the wound bed, clearing a path for the body's natural healing processes to take hold.

Quick Summary

Iruxol mono pomada is an enzymatic ointment containing clostridiopeptidase (collagenase) and other proteases for selective removal of dead tissue from wounds, including leg ulcers and diabetic ulcers. Its action cleanses the wound bed, promoting healing.

Key Points

• Active Ingredients: Iruxol mono pomada contains clostridiopeptidase A (collagenase) and other proteolytic enzymes from Clostridium histolyticum.

• Enzymatic Debridement: The primary function is to selectively break down necrotic (dead) tissue in the wound, facilitating the natural healing process.

• Indications: It is used for various necrotising wounds, including leg ulcers, diabetic ulcers, and pressure sores.

• Application Method: The ointment requires a clean, moist wound bed for the enzymes to be active. It is typically applied as directed by a healthcare professional.

• Drug Interactions: The enzymatic action can be inhibited by some products, including certain antiseptics, heavy metals, detergents, and soaps.

• Localized Side Effects: Common side effects are minor and localized, such as pain, burning, and itching at the application site.

• Important Precautions: Avoid contact with eyes and mucosa. In diabetic patients with dry gangrene, caution is required when moistening the wound.

Understanding Iruxol Mono Pomada

Iruxol mono pomada is a specialized topical medication primarily used in advanced wound management for enzymatic debridement. It is formulated as a brown, lipophilic ointment with a faint odor. The active ingredients are proteolytic enzymes, including clostridiopeptidase A (collagenase) and associated proteases, which are extracted from Clostridium histolyticum. The base of the ointment consists of liquid and white soft paraffin.

Unlike harsh mechanical debridement, this ointment uses the selective action of its enzymes to break down necrotic, or dead, tissue without damaging healthy, living tissue. The removal of dead tissue is a critical first step in wound care, as it eliminates a medium for bacterial growth and allows for proper granulation (new tissue formation) and epithelialization (closure of the wound) to occur.

The Mechanism of Enzymatic Debridement

Enzymatic debridement, the process powered by Iruxol mono pomada, is a targeted biochemical process. Collagenases are a class of proteolytic enzymes uniquely capable of breaking down the native collagen strands that hold necrotic material together in the wound bed. By disrupting these collagen fibers, the dead tissue becomes unanchored and can be easily removed.

How Collagenase Works in the Wound Bed

• Selective Action: The enzyme specifically targets denatured collagen within the dead tissue, leaving healthy tissue untouched.
• Collagen Breakdown: It hydrolyzes the peptide bonds in the collagen, effectively dissolving the structural integrity of the necrotic material.
• Wound Cleansing: As the dead tissue is broken down, it becomes easier to clean from the wound, creating a clean base for healing.

Indications for Using Iruxol Mono Pomada

Iruxol mono pomada is indicated for the enzymatic debridement of various types of necrotising wounds. These include both acute and chronic wounds that are slow to heal due to the presence of dead tissue.

• Leg Ulcers: For wounds on the legs, particularly those associated with vascular issues, removing necrotic tissue is vital.
• Diabetic Ulcers: In diabetic patients, ulcers often develop with significant necrotic tissue, and enzymatic debridement offers a gentle option.
• Pressure Sores (Decubitus Ulcers): Patients with limited mobility frequently develop pressure sores that can benefit from the targeted cleansing action of the ointment.
• Minor Injuries and Burns: The ointment can also be applied to minor skin abrasions, lacerations, and burns to promote effective wound healing.

Comparison of Debridement Methods

Different types of wounds require specific approaches to debridement. Here is a comparison of enzymatic debridement using Iruxol mono with other common methods:

Method	Mechanism	Advantages	Disadvantages	Suitability
Enzymatic (Iruxol mono)	Uses enzymes (collagenase) to selectively break down necrotic tissue.	Selective, preserves healthy tissue, less painful than surgical debridement.	Can be slow, requires moist wound bed, potential drug interactions.	Chronic wounds (diabetic ulcers, pressure sores).
Surgical	Removal of dead tissue using a scalpel or other surgical tools.	Rapid and complete debridement, ideal for severe or infected wounds.	Invasive, requires anesthesia, risk of bleeding and infection.	Deep wounds, extensive necrotic tissue, sepsis.
Autolytic	Body's own enzymes break down necrotic tissue using a moist dressing.	Non-invasive, gentle, effective.	Can be slow, risk of maceration (skin softening) if not managed properly.	Non-infected wounds with minimal necrotic tissue.
Mechanical	Non-selective removal using wet-to-dry dressings or wound irrigation.	Inexpensive, relatively easy to perform.	Non-selective, painful, can damage healthy tissue, carries infection risk.	Wounds with loose debris and minimal necrosis.

How to Apply Iruxol Mono Pomada

For effective treatment, proper application is essential. Always follow your doctor's or pharmacist's instructions.

1. Cleanse the Wound: Before each application, gently clean the wound surface with a compatible solution, such as physiological saline (0.9% NaCl). This removes exudate and any loose debris.
2. Moisten the Wound: Ensure the wound bed is moist. If it is dry, moisten it with saline. For wounds with hard scabs, a moist dressing can help soften them prior to application.
3. Apply the Ointment: Spread a thin layer of Iruxol mono pomada directly onto the wound surface as directed by a healthcare professional.
4. Protect Healthy Skin: To prevent irritation, it is standard practice to protect the surrounding healthy skin with a barrier cream or paste.
5. Cover the Wound: Cover the area with a sterile, appropriate secondary dressing.
6. Change Dressing: Change the dressing and reapply the ointment as instructed by a healthcare professional.

Potential Side Effects and Precautions

While generally well-tolerated, some individuals may experience side effects. It is important to be aware of these and other important precautions.

• Common Side Effects: Localized reactions at the application site are the most frequent side effects, including pain, itching (pruritus), burning, and redness (erythema). These are usually mild and temporary.
• Hypersensitivity: In rare cases, allergic reactions can occur. If severe irritation or rash develops, discontinue use and consult a doctor.
• Inhibiting Agents: The enzymatic action of Iruxol mono is sensitive to certain substances. Avoid using the following on the wound area with Iruxol mono: antiseptics, detergents, soaps, and products containing heavy metals. Some antibiotics like tyrothricin, gramicidin, and tetracyclines can also inhibit its activity.
• Diabetic Caution: In diabetic patients with dry gangrene, the wound should be moistened with caution to avoid it converting to a moist gangrene.
• Pregnancy and Breastfeeding: Use in the first trimester of pregnancy is not generally recommended unless considered strictly necessary by a doctor. Excretion into breast milk is unlikely due to minimal systemic absorption.

For more detailed information, consult the Summary of Product Characteristics from a reliable source.

Conclusion

Iruxol mono pomada represents a valuable treatment option in modern wound care, providing a selective and gentle method of debriding necrotic tissue. By leveraging the power of collagenase enzymes, it helps to effectively cleanse chronic and slow-healing wounds, creating the optimal conditions for natural regeneration and epithelialization. Correct application and adherence to precautions, particularly regarding incompatible substances, are crucial for maximizing the ointment's therapeutic effects and ensuring a successful healing process. As with any medication, consultation with a healthcare professional is always recommended to determine the most appropriate course of treatment for specific wound types.

Frequently Asked Questions

What is the main active ingredient in Iruxol mono pomada?

The main active ingredient is clostridiopeptidase A, a collagenase enzyme, along with other associated proteases derived from Clostridium histolyticum.

How does Iruxol mono work to heal wounds?

It works through a process called enzymatic debridement. The enzymes selectively break down the denatured collagen in necrotic tissue, which cleanses the wound and creates a better environment for new, healthy tissue to grow.

What types of wounds can be treated with Iruxol mono?

Iruxol mono is indicated for treating necrotizing wounds, such as leg ulcers, diabetic ulcers, pressure sores, and burns of limited surface area.

How often should I apply Iruxol mono pomada?

The ointment is generally applied as directed by a healthcare professional, typically once or twice daily, to a clean and moist wound surface.

Does Iruxol mono pomada contain an antibiotic?

Iruxol mono pomada does not contain an antibiotic. However, some versions of Iruxol may contain antibiotics like chloramphenicol, so it's important to check the specific product's formulation.

Can I use Iruxol mono with other wound care products?

You should not use Iruxol mono with products containing antiseptics, heavy metals, detergents, or certain local antibiotics (like tyrothricin), as they can inhibit its enzymatic activity.

What should I do if the wound is dry before applying the ointment?

For the ointment to be effective, the wound bed must be moist. If it is dry, it should be moistened with a physiological saline solution before application.