What is Ketgo cream used for? Unpacking its antifungal properties
Ketgo cream, containing the active ingredient ketoconazole, is a topical antifungal medication used to treat superficial fungal and yeast skin infections. Ketoconazole belongs to the imidazole class of antifungals and works by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption compromises the cell membrane, leading to the death of the fungus or inhibiting its growth.
Ketgo cream is prescribed for several common skin conditions, including Athlete's foot, Ringworm of the body, Ringworm of the groin (jock itch), Seborrheic dermatitis, Tinea versicolor, and Cutaneous candidiasis.
How does Ketgo cream work?
Ketoconazole is a broad-spectrum antifungal that targets fungal cell membranes by inhibiting the enzyme necessary for ergosterol synthesis. Ergosterol is essential for maintaining the stability and integrity of the fungal cell membrane. By blocking its production, ketoconazole disrupts the membrane, causing it to become permeable and lose vital components. This leads to cellular dysfunction and the death of the fungal cell.
Proper application and important considerations
Correct application is vital for the cream's effectiveness and to prevent infection recurrence. Clean and dry the affected area, wash hands before and after application, and apply a thin, even layer covering the infected area and a small portion of surrounding healthy skin. Unless advised by a doctor, do not cover the treated area with bandages.
Comparison of antifungal creams
Feature | Ketoconazole Cream (e.g., Ketgo, Nizoral) | Clotrimazole Cream (e.g., Lotrimin AF) |
---|---|---|
Active Ingredient | Ketoconazole | Clotrimazole |
Drug Class | Imidazole antifungal | Imidazole antifungal |
Availability | Prescription-only for 2% cream; some lower-strength shampoos may be over-the-counter. | Typically available over-the-counter (OTC). |
Mechanism of Action | Inhibits ergosterol synthesis, causing cell membrane disruption. | Inhibits ergosterol synthesis, damaging the fungal cell membrane. |
Frequency of Use | Usually applied once daily for most infections. | Typically requires application twice daily. |
Spectrum of Use | Broad, includes ringworm, jock itch, athlete's foot, tinea versicolor, cutaneous candidiasis, and seborrheic dermatitis. | Used for athlete's foot, jock itch, and ringworm; does not treat tinea versicolor or seborrheic dermatitis. |
Allergy Risk | Small risk of allergic contact dermatitis; caution advised for those with sulfite sensitivity. | Generally well-tolerated with low risk of side effects. |
Precautions and side effects
Ketoconazole cream is for external use only. Mild reactions at the application site, such as burning, irritation, itching, or redness, are common. Serious allergic reactions are rare but require immediate medical attention. Treatment duration varies depending on the condition.
Conclusion
Ketgo cream, with the active ingredient ketoconazole, is an antifungal treatment for various skin infections. It works by disrupting fungal cell membranes and is effective against conditions like ringworm and seborrheic dermatitis. Following application instructions and completing the full course is important. Consulting a healthcare professional is recommended to confirm if it is the right treatment for your condition. Additional information can be found via {Link: DailyMed https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=39b85d6a-9133-42e6-b7f8-58f045e9b9f0}.