What is Levo 5 Plus used for? An In-depth Guide to This Allergy Medication

October 8, 2025 •

3 min read

Levo 5 Plus is a combination medication containing levocetirizine and montelukast, prescribed to treat various allergic conditions, with clinical studies demonstrating its enhanced effectiveness over monotherapy for perennial allergic rhinitis. By targeting two different chemical pathways involved in allergic responses, it provides comprehensive relief for patients struggling with persistent symptoms.

Quick Summary

This guide explains the dual-action mechanism of Levo 5 Plus, exploring its primary uses for allergic rhinitis, asthma, and chronic urticaria. It covers how the medication works, potential side effects, and important safety considerations for patients.

Key Points

Dual-Action Formula: Levo 5 Plus contains both the antihistamine levocetirizine and the anti-inflammatory montelukast to target multiple aspects of the allergic response.
Treats Multiple Allergic Conditions: It is used to manage allergic rhinitis, asthma, and chronic urticaria, providing relief from a wide range of symptoms.
Not a Steroid: Despite its potent anti-inflammatory effects, Levo 5 Plus is not a steroid-based medication.
Potential for Drowsiness: The medication can cause sleepiness or fatigue, and patients should exercise caution when driving or operating machinery until they understand its effects.
Enhanced Efficacy: Clinical evidence suggests that the combination of levocetirizine and montelukast can be more effective for some patients than using either drug alone.
Doctor's Supervision is Key: As a prescription medication with potential side effects and interactions, it should only be used under the guidance of a healthcare provider.

What are the active ingredients in Levo 5 Plus?

Levo 5 Plus is a combination of two medications: Levocetirizine and Montelukast. This combination targets allergic and inflammatory conditions.

Levocetirizine (5mg): A second-generation antihistamine that blocks histamine, relieving symptoms like sneezing, itching, and runny nose.
Montelukast (10mg): A leukotriene receptor antagonist that blocks leukotrienes, which are involved in inflammation and airway narrowing, helping to reduce swelling and improve breathing.

How Levo 5 Plus works for allergic conditions

Levo 5 Plus combines the effects of levocetirizine and montelukast to address allergy symptoms. Levocetirizine provides quick relief from histamine-related symptoms, while montelukast targets inflammation for sustained control. This combination can be more effective for some patients than using either medication alone. Studies on children with perennial allergic rhinitis have shown the combination is more effective at reducing nasal symptoms.

Medical applications of Levo 5 Plus

Levo 5 Plus is prescribed for several related medical conditions.

Treatment of allergic rhinitis

It is used for both seasonal and perennial allergic rhinitis, relieving symptoms like sneezing, blocked or runny nose, and itchy, watery eyes.

Management of asthma

While not for acute attacks, Levo 5 Plus helps manage asthma, especially when triggered by allergies, by reducing airway inflammation and potentially reducing the need for other medications.

Alleviating chronic urticaria (hives)

Levo 5 Plus can provide relief for chronic hives by reducing skin inflammation and alleviating itching and swelling.

Potential side effects and precautions

Levo 5 Plus is generally well-tolerated, but some side effects may occur.

Common side effects: drowsiness, dizziness, headache, dry mouth, fatigue, abdominal pain, and nausea. Drowsiness can affect driving or operating machinery.
Serious side effects: Rare but include allergic reactions, mood changes, or vision changes. Seek immediate medical attention if serious symptoms occur.

Precautions:

Alcohol: Avoid alcohol due to increased drowsiness.
Kidney or Liver Disease: Use with caution and inform your doctor, as use adjustments may be needed.
Pregnancy and Breastfeeding: Consult a healthcare provider before use.
Allergy Testing: Discontinue several days before allergy skin tests.

Comparison of Levo 5 Plus vs. Monotherapy

This table highlights the differences between Levo 5 Plus and its individual components.


Feature	Levo 5 Plus (Combination Therapy)	Levocetirizine (Monotherapy)	Montelukast (Monotherapy)
Mechanism	Blocks histamine and leukotrienes.	Blocks histamine.	Blocks leukotrienes.
Speed of Action	Rapid relief of immediate symptoms and longer-term anti-inflammatory effects.	Rapid relief of sneezing and itching.	Slower onset, primarily reduces inflammation.
Symptom Coverage	Broader coverage including nasal congestion, airway inflammation, and skin reactions.	Most effective for sneezing, runny nose, and itching.	Primarily targets airway inflammation, useful for nasal congestion and asthma.
Effectiveness	More effective for some with allergic rhinitis than either agent alone.	Effective for classic antihistamine-responsive symptoms.	Effective for managing asthma and related nasal inflammation.

Important considerations and conclusion

Levo 5 Plus manages persistent allergic conditions by addressing both immediate reactions and inflammation. Studies support its effectiveness for allergic rhinitis, asthma, and chronic urticaria, showing better results than single ingredients. Be aware of side effects like drowsiness and follow your doctor's instructions, especially for children or those with kidney issues. Consult your healthcare provider to determine if Levo 5 Plus is suitable for you and to discuss potential risks or interactions. The combination can improve quality of life for those with chronic allergies and respiratory issues.

Is Levo 5 Plus a steroid?

No, Levo 5 Plus is not a steroid. It contains levocetirizine, an antihistamine, and montelukast, a leukotriene receptor antagonist, which block chemical messengers causing allergic symptoms and inflammation, not through steroid mechanisms.

Based on information from the Mayo Clinic, levocetirizine is an antihistamine, and montelukast is an anti-inflammatory.

Frequently Asked Questions

The primary use of Levo 5 Plus is to relieve and/or prevent the symptoms of allergic rhinitis (seasonal and perennial), manage asthma, and treat chronic urticaria (hives).

Levocetirizine blocks histamine, which causes classic allergy symptoms like itching and sneezing. Montelukast blocks leukotrienes, which cause inflammation and swelling in the airways. The combined effect provides more comprehensive relief.

For some patients, yes. Clinical studies have shown that the combination therapy can be more effective in reducing symptoms of allergic rhinitis and improving quality of life compared to using montelukast or levocetirizine alone.

No, Levo 5 Plus is not intended for treating an acute asthma attack. It is used for long-term control by reducing airway inflammation and preventing symptoms.

Common side effects include drowsiness, fatigue, headache, dizziness, dry mouth, and abdominal pain. If any side effects are persistent or severe, consult your doctor.

Levo 5 Plus may cause drowsiness or dizziness in some people. You should not drive or operate heavy machinery until you are aware of how the medication affects you.

Levo 5 Plus should be taken as directed by your healthcare provider. It is important to follow their specific instructions regarding administration.

The use of Levo 5 Plus in children should only be done under the supervision of a pediatrician, as the use and appropriateness must be determined by a doctor.