What is Qlocam?: Uses, Side Effects, and Pharmacology

QLOCAM is a brand name for the benzodiazepine medication clobazam, used for the short-term relief of severe anxiety, anxiety before operations, and symptoms of acute alcohol withdrawal. As a prescription drug, it is important for patients to understand its pharmacological properties, potential side effects, and precautions before use.

Quick Summary

QLOCAM is a benzodiazepine-class medication containing the active ingredient clobazam, which has a calming effect on the brain. It is prescribed for severe anxiety, pre-operative anxiety, and acute alcohol withdrawal. Patients must use it under strict medical supervision due to potential dependence and adverse reactions.

Key Points

• Active Ingredient: QLOCAM is a brand name for the benzodiazepine medication clobazam, which has a calming effect on the brain.

• Primary Uses: It is prescribed for short-term relief of severe anxiety, pre-operative anxiety, and acute alcohol withdrawal symptoms.

• Potential for Dependence: Due to a significant risk of dependence, QLOCAM is intended for short-term use and must not be stopped abruptly.

• Distinct Pharmacological Profile: As a 1,5-benzodiazepine, clobazam may offer effective anxiety relief with less sedation and motor impairment compared to some other benzodiazepines.

• Serious Side Effect: QLOCAM's active ingredient has been associated with rare but serious skin reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

• Precautions: Contraindications include severe liver or respiratory issues, myasthenia gravis, and a history of substance abuse.

Understanding Qlocam and its Active Ingredient

QLOCAM is a registered brand name for the medication clobazam, which belongs to a class of drugs called benzodiazepines. While benzodiazepines are well-known for their sedative properties, clobazam is a 1,5-benzodiazepine, possessing a unique pharmacological profile compared to other more common 1,4-benzodiazepines like diazepam. This distinction allows for effective anxiolytic (anxiety-reducing) properties with less pronounced sedative effects and motor coordination impairment, particularly at lower amounts.

The medication is formulated as both capsules and scored tablets, with the active ingredient clobazam accompanied by excipients like lactose monohydrate and magnesium stearate. Its specific mechanism works by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which in turn reduces neuronal excitability and produces a calming effect.

Therapeutic Indications for Qlocam

QLOCAM is prescribed for a few key conditions, always intended for short-term use due to the risk of dependency and withdrawal symptoms upon abrupt cessation. Its primary applications include:

• Severe Anxiety: For patients experiencing anxiety that is severe, disabling, or causing significant stress, QLOCAM can provide short-term relief.
• Pre-operative Medication: It is used to relieve anxiety and tension in patients before undergoing an operation.
• Acute Alcohol Withdrawal Syndrome: QLOCAM can be effective in managing the acute symptoms associated with alcohol withdrawal.
• Adjunctive Therapy for Seizures: In some regions, clobazam (the active ingredient) is used as an adjunctive treatment for certain forms of epilepsy, such as Lennox-Gastaut syndrome.

Potential Side Effects and Drug Interactions

Like all medications, QLOCAM carries a risk of side effects. While tolerance to some of these can develop over time, patients must be aware of them and report any unusual symptoms to their healthcare provider.

Common side effects may include:

• Drowsiness, sedation, and fatigue
• Dizziness and coordination problems
• Headache
• Nausea and constipation
• Dry mouth
• Memory impairment, especially anterograde amnesia

Serious or rare side effects include:

• Serious Skin Reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported, with an FDA warning issued in December 2023 for the active ingredient clobazam regarding Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).
• Paradoxical Reactions: Behavioral changes such as agitation, aggression, and irritability can occur, particularly in children and the elderly.
• Dependence and Withdrawal: Long-term use can lead to physical and psychological dependence. Abrupt discontinuation can cause withdrawal symptoms, including seizures and hallucinations.
• Suicidal Thoughts: A small number of patients taking anticonvulsants like clobazam may experience suicidal thoughts or behavior.

It is crucial to inform your doctor about all medications and supplements you are taking, as QLOCAM can interact with numerous drugs, especially other central nervous system (CNS) depressants like alcohol, narcotic pain relievers, and certain antihistamines.

Important Precautions and Contraindications

QLOCAM should not be used in individuals with certain medical conditions or circumstances. The decision to prescribe must be carefully weighed by a healthcare provider, and patients should disclose their full medical history.

Contraindications for QLOCAM include:

• Hypersensitivity to clobazam or other benzodiazepines
• History of drug or alcohol dependence
• Myasthenia gravis (due to the risk of aggravating muscle weakness)
• Severe respiratory insufficiency or sleep apnea
• Severe liver or kidney disease
• Pregnancy, especially during the first trimester, and breastfeeding

Comparison: Qlocam (Clobazam) vs. Other Benzodiazepines

Feature	Qlocam (Clobazam)	Other Benzodiazepines (e.g., Diazepam)
Classification	1,5-Benzodiazepine	1,4-Benzodiazepine
Sedative Effects	Considered to have less pronounced sedative effects, especially concerning motor coordination impairment.	Generally associated with stronger sedative effects and greater impairment of motor coordination.
Anxiolytic Properties	Effective anxiolytic, comparable in effectiveness to half the dose of diazepam in some studies.	Powerful anxiolytic properties.
Primary Uses	Short-term anxiety, pre-operative, alcohol withdrawal, and sometimes epilepsy adjunct.	Varies widely; includes anxiety, insomnia, seizures, and muscle spasms.
Dependence Risk	Significant risk of dependence, as with other benzodiazepines.	Significant risk of dependence, a common concern for the class.
Unique Adverse Reactions	Notable risk of rare, severe skin reactions like DRESS.	Potential for severe respiratory depression when combined with other CNS depressants.

Conclusion: Responsible Use of Qlocam

QLOCAM is a potent benzodiazepine medication that serves as an effective short-term treatment for severe anxiety and alcohol withdrawal symptoms. Its active ingredient, clobazam, offers a potentially favorable side effect profile compared to other benzodiazepines, particularly concerning sedation and motor function. However, its use is not without risks, including the potential for dependence, withdrawal symptoms upon cessation, and severe adverse reactions like DRESS. Due to these risks, it is essential that QLOCAM is only used under the careful supervision of a healthcare provider. Patients should follow medical instructions precisely, never stop the medication abruptly, and report any concerning side effects. The informed use of QLOCAM and open communication with your doctor are key to managing treatment safely and effectively.

For more detailed professional information on the active ingredient, clobazam, you can visit the NCBI Bookshelf.

Frequently Asked Questions

What is Qlocam? QLOCAM is a brand name for the prescription medication clobazam, a benzodiazepine used to treat severe anxiety, pre-operative anxiety, and acute alcohol withdrawal symptoms.

Is Qlocam addictive? Yes, QLOCAM carries a significant risk of physical and psychological dependence, especially with long-term use. Due to this, treatment is usually limited to a short duration.

What are the main side effects of Qlocam? Common side effects include drowsiness, fatigue, headache, dizziness, and constipation. Serious side effects can include severe skin reactions (SJS, TEN, DRESS) and suicidal thoughts.

Can I stop taking Qlocam suddenly? No, you should never stop taking QLOCAM abruptly. Sudden discontinuation can cause severe withdrawal symptoms, including rebound anxiety, confusion, and seizures. Your doctor will provide a plan for gradual reduction.

Who should not take Qlocam? QLOCAM is contraindicated in individuals with a history of drug or alcohol dependence, myasthenia gravis, severe respiratory insufficiency, and hypersensitivity to benzodiazepines. It is also generally avoided during pregnancy and breastfeeding.

How does Qlocam differ from other benzodiazepines? QLOCAM contains clobazam, a 1,5-benzodiazepine, which can provide anxiolytic effects with potentially less sedation and motor coordination impairment compared to 1,4-benzodiazepines like diazepam.

Can I drink alcohol while on Qlocam? No, it is strongly advised to avoid alcohol when taking QLOCAM. Concomitant use can significantly increase the bioavailability of clobazam and heighten the risk of severe CNS depression, respiratory problems, and potential overdose.

What is the typical use of Qlocam? QLOCAM is generally used for short periods. Your healthcare provider will determine the appropriate duration of treatment based on your condition and response.

Citations

• Qlocam Comb Range Za Qloccomb 2403 00 Epil 20240319. (n.d.). Scribd. Retrieved October 11, 2025, from https://www.scribd.com/document/843164622/Qlocam-Comb-Range-Za-Qloccomb-2403-00-Epil-20240319
• QLOCAM_Comb_Range_ZA_QL.... (n.d.). SAHPRA Repository. Retrieved October 11, 2025, from https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2024/09/QLOCAM_Comb_Range_ZA_QLOCCOMB_2403_00_EPIL_20240319.pdf
• Clobazam - StatPearls - NCBI Bookshelf. (n.d.). National Institutes of Health (NIH). Retrieved October 11, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK541043/
• Lactose monohydrate 141 - SAHPRA Repository. (n.d.). SAHPRA Repository. Retrieved October 11, 2025, from https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2025/05/QLOCAM_TABS_PIL_2025.03.25.pdf
• 1.3.1.1 professional information for medicines for human use. (n.d.). SAHPRA Repository. Retrieved October 11, 2025, from https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2024/09/QLOCAM_Comb_Range_ZA_QLOCCOMB_2403_00_EPI_20240319.pdf
• Consumer Information for: CLOBAZAM-10. (n.d.). Drug and Health Products Portal. Retrieved October 11, 2025, from https://dhpp.hpfb-dgpsa.ca/dhpp/resource/72805/consumer-information
• Clobazam - StatPearls - NCBI Bookshelf. (n.d.). National Institutes of Health (NIH). Retrieved October 11, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK541043/
• Clobazam: MedlinePlus Drug Information. (n.d.). MedlinePlus. Retrieved October 11, 2025, from https://medlineplus.gov/druginfo/meds/a612008.html
• QLOCAM_Comb_Range_ZA_QL.... (n.d.). SAHPRA Repository. Retrieved October 11, 2025, from https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2024/09/QLOCAM_Comb_Range_ZA_QLOCCOMB_2403_00_EPIL_20240319.pdf
• Consumer Information for: CLOBAZAM-10. (n.d.). Drug and Health Products Portal. Retrieved October 11, 2025, from https://dhpp.hpfb-dgpsa.ca/dhpp/resource/72805/consumer-information
• CLOBAZAM - ORAL (Onfi) side effects, medical uses, and drug .... (n.d.). MedicineNet. Retrieved October 11, 2025, from https://www.medicinenet.com/clobazam-oral/article.htm
• 1.3.1.1 professional information for medicines for human use. (n.d.). SAHPRA Repository. Retrieved October 11, 2025, from https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2024/09/QLOCAM_Comb_Range_ZA_QLOCCOMB_2403_00_EPI_20240319.pdf
• About clonazepam - NHS. (n.d.). nhs.uk. Retrieved October 11, 2025, from https://www.nhs.uk/medicines/clonazepam/about-clonazepam/
• A comparison of the efficacy and tolerability of clobazam ... - PubMed. (n.d.). National Institutes of Health (NIH). Retrieved October 11, 2025, from https://pubmed.ncbi.nlm.nih.gov/6137426/
• Clobazam: Pharmacological and therapeutic profile - PMC. (n.d.). National Institutes of Health (NIH). Retrieved October 11, 2025, from https://pmc.ncbi.nlm.nih.gov/articles/PMC1429523/
• Clobazam: a review of its pharmacological properties and ... - PubMed. (n.d.). National Institutes of Health (NIH). Retrieved October 11, 2025, from https://pubmed.ncbi.nlm.nih.gov/6107238/
• What is the mechanism of Clobazam? - Patsnap Synapse. (n.d.). Patsnap Synapse. Retrieved October 11, 2025, from https://synapse.patsnap.com/article/what-is-the-mechanism-of-clobazam

Frequently Asked Questions

What is Qlocam?

QLOCAM is a brand name for the prescription medication clobazam, a benzodiazepine used to treat severe anxiety, pre-operative anxiety, and acute alcohol withdrawal symptoms.

Is Qlocam addictive?

Yes, QLOCAM carries a significant risk of physical and psychological dependence, especially with long-term use. Due to this, treatment is usually limited to a short duration.

What are the main side effects of Qlocam?

Common side effects include drowsiness, fatigue, headache, dizziness, and constipation. Serious side effects can include severe skin reactions (SJS, TEN, DRESS) and suicidal thoughts.

Can I stop taking Qlocam suddenly?

No, you should never stop taking QLOCAM abruptly. Sudden discontinuation can cause severe withdrawal symptoms, including rebound anxiety, confusion, and seizures. Your doctor will provide a plan for gradual reduction.

Who should not take Qlocam?

QLOCAM is contraindicated in individuals with a history of drug or alcohol dependence, myasthenia gravis, severe respiratory insufficiency, and hypersensitivity to benzodiazepines. It is also generally avoided during pregnancy and breastfeeding.

How does Qlocam differ from other benzodiazepines?

QLOCAM contains clobazam, a 1,5-benzodiazepine, which can provide anxiolytic effects with potentially less sedation and motor coordination impairment compared to 1,4-benzodiazepines like diazepam.

Can I drink alcohol while on Qlocam?

No, it is strongly advised to avoid alcohol when taking QLOCAM. Concomitant use can significantly increase the bioavailability of clobazam and heighten the risk of severe CNS depression, respiratory problems, and potential overdose.

What is the typical use of Qlocam?

QLOCAM is generally used for short periods. Your healthcare provider will determine the appropriate duration of treatment based on your condition and response.