What is Rhofade and How Does it Work?
Rhofade, the brand name for oxymetazoline hydrochloride 1% cream, is a prescription medication for persistent facial redness (erythema) associated with rosacea in adults. Its active ingredient, oxymetazoline, is a vasoconstrictor that narrows blood vessels. This is the same active ingredient found in some nasal decongestant sprays, but Rhofade is for skin application.
As a selective alpha-1A adrenoceptor agonist, oxymetazoline in Rhofade activates these receptors on small blood vessels in the facial skin, causing them to constrict. This reduces blood flow and minimizes persistent redness for up to 12 hours.
Usage and Application for Rosacea
Rhofade is applied once daily. A pea-sized amount should be applied in a thin layer to the entire face, avoiding the eyes and lips.
Proper application includes:
- Washing hands immediately after application.
- Priming the pump dispenser before the first use.
- Not applying to irritated skin or open wounds.
Potential Side Effects and Safety Considerations
Rhofade can cause side effects, though often mild to moderate application-site reactions.
Common application-site adverse reactions (reported by ≥1% of subjects) include:
- Dermatitis
- Worsening of rosacea pimples
- Itching (pruritus)
- Redness (erythema)
- Pain
Safety precautions are important for those with certain conditions. As an alpha-adrenergic agonist, Rhofade may affect blood pressure and circulation. Use with caution in patients with a history of cardiovascular disease, orthostatic hypotension, uncontrolled high or low blood pressure, Raynaud's phenomenon, or narrow-angle glaucoma.
Rhofade vs. Mirvaso: A Comparison
Mirvaso (brimonidine) is another topical vasoconstrictor for rosacea redness, but it differs from Rhofade in its active ingredient and side effect profile. Rhofade is reported to have a lower risk of rebound redness or flushing compared to Mirvaso.
| Feature | Rhofade (oxymetazoline) | Mirvaso (brimonidine) |
|---|---|---|
| Active Ingredient | Oxymetazoline hydrochloride | Brimonidine tartrate |
| Mechanism of Action | Alpha-1A adrenoceptor agonist | Alpha-2 adrenergic receptor agonist |
| Indication | Persistent facial erythema associated with rosacea | Persistent facial erythema associated with rosacea |
| Risk of Rebound Redness | Reportedly lower risk | Higher risk reported by some users |
| Duration of Effect | Up to 12 hours | Can provide relief for hours |
| Cost | Prescription, no generic available | Prescription, generic available |
Long-Term Outlook
Consistent daily use of Rhofade may lead to significant and sustained improvement in facial redness for those who tolerate it well. Some studies suggest long-term application could result in a permanent reduction in redness. Individual results vary, and consulting a dermatologist is key to managing rosacea effectively.
Conclusion
Rhofade effectively manages persistent facial redness in adults with rosacea by using the vasoconstrictive properties of oxymetazoline, providing up to 12 hours of relief. While application-site reactions are possible, they are typically manageable. Rhofade may be a good option for those who experienced rebound flushing with Mirvaso. Always consult a healthcare provider to see if Rhofade is appropriate for your condition and medical history. For more information, refer to the FDA prescribing information.
