What is Tagitol V?
Tagitol V is a prescription radiographic contrast agent specifically designed for use during a computed tomography (CT) colonography, often called a virtual colonoscopy. Its primary purpose as a fecal tagging agent is to "tag" or coat any residual stool in the colon. Virtual colonoscopy is a non-invasive procedure using a CT scanner to create images of the colon for detecting abnormalities. Residual stool can sometimes be mistaken for polyps on a scan. By visibly tagging the stool, Tagitol V helps radiologists accurately identify these artifacts, improving diagnostic accuracy.
The Role of Barium Sulfate
The active ingredient in Tagitol V is barium sulfate ($BaSO_4$), which is opaque to x-rays and is not absorbed by the body. It appears bright white on x-ray-based imaging like a CT scan, making residual stool instantly identifiable. The formulation is a low-density, flavored suspension.
How Is Tagitol Used?
Tagitol V is part of the patient’s bowel preparation for a virtual colonoscopy, typically starting the day before the exam with dietary restrictions and a bowel-cleansing agent. Patients usually take Tagitol V at home as directed by their healthcare provider. It is recommended to shake the bottle before use, take the liquid orally as instructed, and drink plenty of fluids afterwards. Following healthcare provider instructions is important.
Side Effects and Safety Profile
Tagitol V can cause side effects, most commonly mild and gastrointestinal. Common side effects include nausea, vomiting, and abdominal cramping. Serious side effects like bowel obstruction, hypersensitivity reactions, GI perforation, and aspiration pneumonitis are possible, with higher risks for patients with certain pre-existing conditions {Link: FDA website https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208143s005lbl.pdf}.
Tagitol vs. Other Barium Sulfate Products
Tagitol V is specifically formulated and approved as a fecal tagging agent for CT colonography, distinct from other barium sulfate products used for different types of GI imaging {Link: FDA website https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208143s005lbl.pdf}.
| Feature | Tagitol V (Barium Sulfate) | Readi-Cat 2 (Barium Sulfate) | Volumen (Barium Sulfate) |
|---|---|---|---|
| Primary Use | Fecal tagging for CT colonography | Oral contrast for abdominal/pelvic CT scans | Oral contrast for GI exams, including CT |
| Formulation | 40% w/v oral suspension, apple-flavored | Ready-to-use oral suspension | High-concentration oral suspension |
| Volume | Low volume | Higher volume (e.g., 250 mL bottles) | Higher volume |
| Mechanism | Tags residual stool to prevent false positives | Opacifies GI tract to improve visualization | Enhances contrast for general GI imaging |
| FDA Approval | Specific FDA approval for CT colonography | Approved for general GI imaging | Approved for general GI imaging |
For more detailed information on Tagitol V's clinical profile, you can visit the Bracco Imaging website.
Conclusion
Tagitol V is an FDA-approved oral contrast agent containing barium sulfate, used to improve the accuracy of virtual colonoscopies by tagging residual fecal matter. Its low-volume formulation and specific mechanism help radiologists distinguish between stool and potential polyps, reducing false positives. Proper administration according to instructions and medical supervision are crucial for effectiveness and patient safety.
