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What is the best painkiller for shoulder pain?

5 min read

Shoulder pain is the third most common musculoskeletal complaint, with a point prevalence ranging from 7% to 26% [1.7.1]. Answering 'What is the best painkiller for shoulder pain?' depends on the pain's cause, which can range from arthritis to tendonitis [1.9.1, 1.9.3].

Quick Summary

Choosing the right medication for shoulder pain depends on the cause and severity. This overview covers over-the-counter NSAIDs, acetaminophen, topical analgesics, and prescription options like corticosteroid injections.

Key Points

  • No Single 'Best' Pill: The most effective painkiller depends on the specific cause of the shoulder pain, such as inflammation or injury [1.2.4, 1.5.6].

  • NSAIDs for Inflammation: For pain caused by inflammation (tendinitis, bursitis), nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen are often recommended [1.2.1, 1.3.5].

  • Acetaminophen for General Pain: For non-inflammatory pain, acetaminophen (Tylenol) is a suitable alternative that is easier on the stomach than NSAIDs [1.3.4, 1.5.3].

  • Topical Options for Localized Relief: Creams and gels, especially those with NSAIDs like diclofenac (Voltaren), provide targeted relief with fewer systemic side effects [1.4.1, 1.4.4].

  • Prescription Treatments for Severe Pain: For intense or persistent pain, a doctor may recommend prescription NSAIDs, corticosteroid injections, or other treatments [1.5.2, 1.6.2].

  • Opioids Are Rarely Used: Due to the high risk of dependency, opioids are reserved for severe, acute pain and are not a standard treatment for common shoulder pain [1.5.3].

  • Consult a Doctor: It's crucial to see a doctor for an accurate diagnosis if pain is severe, persists for weeks, or limits your daily activities [1.8.2, 1.8.3].

In This Article

Understanding the Source of Your Shoulder Pain

Shoulder pain is a common issue stemming from the shoulder's status as the body's most movable joint [1.9.2, 1.9.3]. This wide range of motion makes it susceptible to various problems. Common causes include rotator cuff tendinitis (inflammation of tendons), bursitis, arthritis, rotator cuff tears, and frozen shoulder [1.9.1, 1.9.4, 1.9.5]. The most frequent cause is when rotator cuff tendons get trapped and inflamed, a condition known as impingement syndrome or bursitis [1.9.3, 1.9.5]. The "best" painkiller is one that effectively targets the specific cause of your pain, whether it's inflammation, nerve irritation, or general aches.

Over-the-Counter (OTC) Medications: The First Line of Defense

For minor to moderate shoulder pain, most people can start with over-the-counter options [1.2.2]. These are generally divided into two main categories: nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs work by reducing inflammation in the body, which is a primary source of pain in conditions like bursitis and tendinitis [1.2.1, 1.3.5]. They block enzymes called cyclooxygenase (COX), which prevents the production of pain- and inflammation-causing prostaglandins [1.3.2].

  • Ibuprofen (Advil, Motrin): Often recommended for menstrual cramps and sore muscles, ibuprofen is an effective anti-inflammatory [1.3.5].
  • Naproxen Sodium (Aleve): Naproxen is a powerful OTC anti-inflammatory that offers longer-lasting relief, with one dose lasting up to 12 hours. This makes it particularly effective for conditions like sprains and arthritis [1.2.3, 1.3.5].

While effective, long-term use of NSAIDs can lead to side effects like stomach upset, high blood pressure, and kidney issues [1.2.6, 1.3.2]. They should be used with caution by individuals with heart disease or clotting disorders [1.3.2].

Acetaminophen

Acetaminophen (Tylenol) works differently from NSAIDs. It is not an anti-inflammatory drug; instead, it is thought to work in the central nervous system to block pain signals from reaching the brain [1.2.6, 1.3.4]. It's a good choice for pain that isn't primarily caused by inflammation and for people who cannot tolerate NSAIDs due to stomach issues or other health conditions [1.3.4, 1.5.3]. Acetaminophen is often recommended first for minor ailments due to its safety profile when used correctly [1.3.5]. However, exceeding the recommended dose can cause severe liver damage [1.3.4].

Topical Pain Relievers

For localized pain, topical analgesics can be a great option. These are creams, gels, or patches applied directly to the skin over the painful area [1.2.2]. They offer targeted relief with a much lower risk of systemic side effects compared to oral medications because less of the drug enters the bloodstream [1.4.1, 1.4.4].

  • Topical NSAIDs (e.g., Voltaren Arthritis Pain Gel): Gels containing diclofenac, an NSAID, have been shown to be effective for pain relief, particularly in osteoarthritis [1.4.1, 1.4.4]. Studies show they can provide pain relief similar to oral NSAIDs for acute conditions like sprains and strains [1.4.2].
  • Counterirritants (e.g., Icy Hot, Biofreeze): These products contain ingredients like menthol, camphor, or capsaicin. They create a cooling or heating sensation that distracts the brain from the underlying pain [1.2.2, 1.4.6].

Comparison of Common OTC Painkillers

Medication Type How It Works Best For Key Considerations
Ibuprofen NSAID Reduces inflammation by blocking COX enzymes [1.3.2]. Pain with inflammation (e.g., tendinitis, bursitis, muscle soreness) [1.3.5, 1.5.4]. Can cause stomach irritation; risk of cardiovascular and kidney issues with long-term use [1.2.6, 1.3.2].
Naproxen Sodium NSAID Reduces inflammation with a longer-lasting effect than ibuprofen [1.3.5]. All-day relief from inflammatory pain, such as from arthritis or sprains [1.3.5]. Similar risks to ibuprofen, but fewer daily doses are needed [1.3.5]. Not recommended for people over 65 [1.3.5].
Acetaminophen Analgesic Blocks pain signals in the central nervous system; not an anti-inflammatory [1.3.4]. Pain without significant inflammation (e.g., osteoarthritis, general aches) [1.2.4, 1.3.6]. Safer for the stomach than NSAIDs, but overdose can cause severe liver damage [1.3.4].
Diclofenac Gel Topical NSAID Reduces localized inflammation where applied [1.5.5]. Joint pain from conditions like osteoarthritis, providing targeted relief [1.4.1]. Lower risk of systemic side effects than oral NSAIDs, but can cause skin reactions [1.4.1, 1.4.4].

Prescription-Strength Treatments

When OTC medications don't provide enough relief, a doctor may recommend prescription treatments.

Prescription NSAIDs

If OTC doses are insufficient, a doctor might prescribe stronger NSAIDs like meloxicam or celecoxib [1.2.1, 1.5.4]. These carry similar but potentially heightened risks compared to their OTC counterparts and require medical supervision [1.5.4].

Corticosteroid Injections

For significant inflammation, such as in cases of severe bursitis, tendinitis, or arthritis, a doctor may suggest a corticosteroid injection [1.6.1, 1.6.2]. These powerful anti-inflammatory medications are injected directly into the shoulder joint to deliver targeted, potent relief that can last for weeks or months [1.5.2, 1.6.6]. However, their use is limited, as repeated injections can weaken tendons [1.6.1, 1.6.3].

Opioid Analgesics

Opioids are powerful pain relievers but are generally reserved for severe, acute pain (like after surgery) or in specific chronic pain cases under strict medical guidance [1.5.3, 1.5.6]. Due to significant side effects and the risk of dependency, they are not a first-line treatment for most types of shoulder pain [1.5.3].

When to See a Doctor

You should consult a healthcare provider for shoulder pain if:

  • The pain is persistent and lasts for more than a few weeks [1.8.2, 1.8.3].
  • The pain resulted from a significant injury or fall [1.8.1].
  • You experience intense pain, sudden swelling, or a joint that appears deformed [1.8.1].
  • You have difficulty lifting your arm, reaching behind your back, or performing daily activities [1.8.2, 1.8.3].
  • The pain is accompanied by redness, warmth, or tenderness around the joint [1.8.3].
  • Shoulder pain occurs with shortness of breath or chest tightness, as this could be a sign of a heart attack [1.8.1, 1.9.2].

Conclusion

Ultimately, there is no single "best" painkiller for all types of shoulder pain. The most effective choice depends heavily on the underlying cause. For inflammatory conditions like tendinitis or bursitis, NSAIDs like ibuprofen or naproxen are often recommended [1.2.1]. For non-inflammatory pain, acetaminophen may be a safer choice [1.3.4]. Topical treatments offer targeted relief with fewer side effects [1.4.1]. For severe or persistent pain, prescription options like corticosteroid injections may be necessary [1.6.2]. Always consult with a healthcare professional to get an accurate diagnosis and a personalized treatment plan, especially before starting any new medication. Self-care measures like rest and applying ice can also be beneficial [1.2.2].


Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Mayo Clinic: Shoulder Pain

Frequently Asked Questions

For inflammatory pain (like from bursitis or tendinitis), NSAIDs such as ibuprofen (Advil) or naproxen (Aleve) are often recommended [1.2.1]. For pain without much inflammation, acetaminophen (Tylenol) is a good choice [1.2.4]. Topical pain relievers can also be effective [1.2.2].

It depends on the cause. Advil (ibuprofen) is an NSAID that reduces inflammation, making it better for conditions like tendinitis [1.3.5]. Tylenol (acetaminophen) only relieves pain and is better for those who need to avoid NSAIDs or have non-inflammatory pain [1.3.4].

Topical NSAIDs like Voltaren (diclofenac gel) can be very effective, providing localized pain relief with a lower risk of systemic side effects than oral pills [1.4.1, 1.4.4]. They work best for pain in joints close to the skin's surface [1.5.3].

A cortisone shot may be considered if your shoulder pain is severe, caused by significant inflammation, and has not responded to OTC medications and rest [1.6.1, 1.6.2]. It is a powerful, targeted anti-inflammatory treatment [1.5.1].

While they work differently, you should always consult a doctor or pharmacist before combining any medications to ensure it is safe for you and to avoid exceeding recommended daily dosages [1.3.2].

Long-term use of NSAIDs can increase the risk of stomach ulcers, high blood pressure, and kidney or heart problems [1.2.6]. Long-term high doses of acetaminophen can cause liver damage [1.3.4].

You should see a doctor if the pain is severe, lasts more than a few weeks, was caused by a traumatic injury, or significantly limits your movement and daily activities [1.8.2, 1.8.3].

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.