What is the best pill for hemorrhoids? A comprehensive guide to oral treatments

October 8, 2025 •

3 min read

According to some estimates, up to 75% of people will experience hemorrhoids at some point in their lives, making finding effective relief a common goal. Determining what is the best pill for hemorrhoids depends heavily on the specific symptoms a person is experiencing.

Quick Summary

Oral medications for hemorrhoids include fiber supplements, stool softeners, pain relievers, and flavonoid pills. Each targets different symptoms, from constipation and discomfort to bleeding and swelling, and should be used alongside lifestyle changes for optimal results.

Key Points

Fiber and Stool Softeners: These are the best oral options for addressing and preventing the root cause of hemorrhoids: constipation and straining.
Flavonoids (Venotonics): Medications like diosmin and hesperidin (MPFF) are effective pills for treating inflammation, bleeding, and swelling by strengthening blood vessel walls.
Over-the-Counter Pain Relievers: NSAIDs (ibuprofen) and acetaminophen can provide temporary relief for pain and discomfort during a flare-up.
Holistic Treatment: The best results come from combining oral pills with lifestyle changes such as a high-fiber diet, hydration, and improved toilet habits.
Consult a Professional: Severe or persistent symptoms and heavy bleeding require medical evaluation to rule out other conditions and determine the most appropriate course of action.

Finding the most effective treatment for hemorrhoids is not a one-size-fits-all solution. Oral medications can be an important part of managing symptoms and addressing underlying issues like constipation or venous inflammation. Unlike topical treatments that offer localized relief, pills work internally to manage causes and provide sustained comfort.

The foundational approach: Fiber supplements and stool softeners

Diet plays a crucial role in managing hemorrhoids, as straining during bowel movements, often due to constipation, is a primary cause of flare-ups. Oral treatments that improve bowel habits are therefore essential.

Fiber supplements

These bulk-forming laxatives absorb water, softening stools and making them easier to pass, which prevents straining. Common examples include psyllium (e.g., Metamucil) and methylcellulose (e.g., Citrucel). Adequate water intake is necessary when taking fiber supplements.

Stool softeners

Medications like docusate sodium (e.g., Colace) increase water in the stool, making it softer and reducing strain. These are generally gentle and can be used for several days.

Managing pain and inflammation with oral pain relievers

Oral pain relievers can help manage acute pain and inflammation.

NSAIDs (Ibuprofen, Naproxen): Ibuprofen (Advil) can reduce both pain and inflammation. Consult a doctor about long-term use, especially with other health conditions.
Acetaminophen (Tylenol): This provides pain relief but does not reduce inflammation like NSAIDs.

Targeting the source: Flavonoid medications (Venotonics)

Venotonics target the underlying vascular issues associated with hemorrhoids. These are widely used globally, often as supplements in the U.S..

Micronized Purified Flavonoid Fraction (MPFF)

MPFF, containing diosmin and hesperidin (marketed as Daflon in some regions), has demonstrated several benefits in clinical studies. It strengthens vein walls, reduces swelling by decreasing capillary permeability, and has anti-inflammatory effects, helping to relieve pain, itching, and bleeding.

Other flavonoid supplements

Various supplements containing flavonoids and herbal ingredients like horse chestnut and witch hazel are marketed for hemorrhoids. Their efficacy can vary and they are not as regulated as prescription medications.

Comparison of oral hemorrhoid treatments


Treatment Type	Primary Benefit	Onset of Action	Best For	Considerations
Fiber Supplements	Prevents constipation and straining	Days to weeks	Long-term prevention, reducing bleeding	Must be taken with plenty of water. Gradual increase to avoid bloating.
Stool Softeners	Softens stool, eases constipation	1-3 days	Short-term constipation relief	Less effective for pre-existing pain/inflammation.
OTC Pain Relievers	Manages pain and inflammation	Hours	Short-term pain relief during a flare-up	Not a cure. Use NSAIDs cautiously; acetaminophen lacks anti-inflammatory effect.
Flavonoids (MPFF)	Improves venous tone, reduces inflammation	Days to weeks	Bleeding, swelling, and chronic symptoms	Not FDA-approved for this use in the U.S. Consult a doctor for proper diagnosis and guidance.

The holistic approach: Lifestyle modifications and when to see a doctor

Oral pills are most effective when combined with lifestyle changes, including:

Increasing dietary fiber: Eat more whole grains, fruits, and vegetables.
Staying hydrated: Drink 6 to 8 glasses of water daily.
Exercising regularly: Physical activity can improve bowel motility.
Practicing good toilet habits: Avoid straining and prolonged sitting.

If you have persistent or severe symptoms, heavy bleeding, or lack relief from conservative measures, see a healthcare professional. They can confirm the diagnosis, rule out other conditions, and recommend appropriate treatments, including prescription options or procedures if needed for conditions like thrombosis.

Conclusion There isn't one best pill for hemorrhoids; treatment should be individualized. Fiber supplements are best for managing constipation and preventing flare-ups. OTC pain relievers help with short-term pain. Flavonoids like diosmin and hesperidin show good evidence for treating underlying vascular issues, reducing bleeding and swelling. Combining oral medication with healthy dietary and lifestyle habits is the most effective approach. Always consult a healthcare provider for personalized advice. For more information, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) offers resources on hemorrhoid treatment and management.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Frequently Asked Questions

Oral pills and creams serve different functions. Creams, ointments, and suppositories are for localized, topical relief of external symptoms like itching and pain, while oral pills address underlying systemic issues like constipation or venous inflammation. Often, a combination of both is most effective.

Yes, over-the-counter NSAIDs like ibuprofen can be used to help manage hemorrhoid pain and reduce inflammation in the short term. However, you should not use them for more than a few days without consulting a doctor, and they don't treat the underlying condition.

Fiber supplements, such as psyllium, work by softening stool and increasing its bulk, which prevents constipation and reduces the need to strain during bowel movements. This is crucial for both treating existing hemorrhoids and preventing future flare-ups.

The time frame depends on the medication. Stool softeners may begin working within 1 to 3 days. Flavonoid pills may take a week or more to show significant improvement in symptoms like bleeding and swelling. Fiber supplements can take days or weeks of consistent use for maximum effect.

Flavonoid supplements like MPFF are generally considered safe and have shown efficacy in clinical studies. However, they are not FDA-approved in the U.S. for hemorrhoid treatment, and like any supplement, should be discussed with a healthcare provider before use.

You should see a doctor if your symptoms don't improve after a week of home care, if you experience severe pain, or if you have rectal bleeding. It is also important to seek medical advice if you are pregnant, breastfeeding, or have other medical conditions.

While oral medications like flavonoids can help reduce the swelling and inflammation of hemorrhoids, they do not typically cause them to 'shrink' in the way a medical procedure would. They are more for symptom management and improvement of venous tone.