Combination medications containing hydrocodone and acetaminophen, once known by brand names like Vicodin, Norco, and Lortab, are prescribed for moderate to moderately severe pain. This pairing combines an opioid (hydrocodone) with a non-opioid pain reliever (acetaminophen) for enhanced pain relief compared to either drug used alone. While there isn't one single "most common" strength, current formulations reflect a significant safety change by the FDA.
The FDA's Impact on Acetaminophen Strength
In 2011, the FDA mandated that all prescription combination products containing acetaminophen limit the amount to no more than 325 mg per dosage unit. This action aimed to mitigate the risk of severe liver injury from acetaminophen overdose, as previous formulations could contain up to 750 mg per tablet. Manufacturers subsequently reformulated these products, standardizing the acetaminophen content while offering varying hydrocodone levels.
Current Common Tablet Strengths
Hydrocodone with acetaminophen tablets are available in several common strengths, listed as hydrocodone amount (mg) / acetaminophen amount (mg). Popular formulations include combinations pairing acetaminophen at 300 mg or 325 mg with different amounts of hydrocodone, such as 2.5 mg, 5 mg, 7.5 mg, and 10 mg.
Comparison of Generic Formulations
Though original brand names like Vicodin and Norco have changed, their distinct generic formulations remain widely used. The key difference often lies in the acetaminophen content.
| Brand/Generic Example | Hydrocodone Strength (mg) | Acetaminophen Strength (mg) | Notes |
|---|---|---|---|
| Generic Norco | Varies | 325 | Formulations typically contain 325 mg acetaminophen. |
| Generic Vicodin | Varies | 300 | Formulations typically contain 300 mg acetaminophen. |
| Hycet/Generic | Varies | 325 | Also available as oral solutions per 15 mL. |
Administration and Safety Considerations
A healthcare provider determines the appropriate use based on pain severity, patient response, and overall health. It is crucial to prevent overdose, particularly the risk of liver damage from exceeding the maximum recommended daily acetaminophen limit from all sources, including over-the-counter medications. Hydrocodone with acetaminophen is a Schedule II controlled substance due to its potential for abuse and dependence. It should be used at the lowest effective amount for the shortest duration necessary, with discontinuation managed under medical supervision if needed.
Oral Solution Strengths
Oral solutions are available for patients unable to take tablets. Common strengths per 15 mL (one tablespoon) include formulations pairing varying amounts of hydrocodone with 325 mg of acetaminophen.
Conclusion
Common strengths of hydrocodone with acetaminophen are varied, typically featuring 300 mg or 325 mg of acetaminophen paired with differing amounts of hydrocodone. This standardization of acetaminophen levels by the FDA was a key safety measure against liver damage. The appropriate use is individualized by a physician to manage pain effectively. Patient safety hinges on understanding the acetaminophen content and strictly following prescribed directions. Further information can be found through resources like the U.S. National Library of Medicine.
