Understanding Gynatrop and Its Active Ingredient, Buserelin
Gynatrop is a prescription injectable medication whose active ingredient is Buserelin [1.4.1, 1.4.3]. Buserelin is a synthetic version of a naturally occurring hormone known as gonadotropin-releasing hormone (GnRH) [1.2.1]. It functions by acting on the pituitary gland to regulate the body's production of other hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [1.6.9]. By controlling these hormonal pathways, Gynatrop is used in several medical contexts, most notably in assisted reproduction technologies.
Search results indicate that Gynatrop and a similarly named product, Gynarich, both contain Buserelin and are manufactured by Intas Pharmaceuticals Ltd., primarily available in markets like India [1.4.1, 1.4.2].
Primary Pharmacological Uses of Gynatrop
The ability of Buserelin to regulate hormone production makes Gynatrop a versatile medication prescribed for several conditions:
- Female Infertility (Assisted Reproduction/IVF): In in-vitro fertilization (IVF) protocols, Gynatrop is used to control hormone levels during ovarian stimulation. It helps prevent premature ovulation, allowing for the retrieval of mature eggs for fertilization [1.2.1].
- Endometriosis: The medication helps alleviate symptoms of endometriosis, such as pelvic pain, by reducing the production of female sex hormones that cause endometrial tissue to grow [1.2.1].
- Prostate Cancer: In men, Gynatrop is used to treat hormone-dependent prostate cancer by significantly lowering testosterone levels, which can fuel the growth of cancer cells [1.2.2].
What is the Cost of Gynatrop Injection?
The cost of Gynatrop injection varies dramatically based on geographic location. In India, where the brand appears to be most common, the price is relatively low. One online pharmacy lists a 2.5 ml vial of Gynatrop for ₹142, while another lists a 5 ml vial for ₹320 [1.2.8, 1.3.7]. Another related Buserelin product, Gynarich, is listed at ₹366 for a 5mL pack [1.3.5].
In contrast, Buserelin is available in other countries under different brand names, and the price point is significantly different. For example, in Canada, a multi-dose vial of Suprefact (Buserelin acetate) is listed for $84.22 [1.3.8]. In the United States, while Gynatrop itself is not commonly listed, other GnRH-related fertility drugs can cost hundreds or even thousands of dollars per cycle [1.3.1].
Key Factors That Influence Fertility Drug Costs
Several variables can affect the final price a patient pays for Gynatrop or similar fertility medications:
- Dosage and Treatment Duration: The required dosage and the length of the treatment protocol are the most significant cost drivers. Longer or higher-dose regimens will require more medication, thus increasing the total cost.
- Pharmacy and Location: As seen with the price differences between India and North America, pharmacy markups and national pricing regulations have a major impact. Prices can vary even between different pharmacies in the same city.
- Insurance Coverage: Whether a patient's health insurance plan covers fertility treatments is a critical factor. Many plans have limited or no coverage for IVF and related medications.
- Brand vs. Generic: While Gynatrop is a brand name, the availability of generic Buserelin could offer cost savings where available.
Cost Comparison: Gynatrop (Buserelin) vs. Other Fertility Injections
To provide context, it's helpful to compare the cost of Buserelin to other common fertility injections. The following table uses prices from a Canadian online pharmacy for standardization where possible [1.3.8].
| Medication (Active Ingredient) | Use in Fertility Treatment | Example Price (CAD)* |
|---|---|---|
| Suprefact (Buserelin Acetate) | Prevents premature ovulation (GnRH agonist) | $84.22 |
| Orgalutran (Ganirelix Acetate) | Prevents premature ovulation (GnRH antagonist) | $103.53 |
| Ovidrel (Choriogonadotropin alfa) | Triggers final egg maturation and ovulation | $87.59 |
| Gonal-F Pen 300IU (Follitropin alfa) | Stimulates follicle/egg development | $362.17 |
| Menopur 75IU (Menotropins) | Stimulates follicle/egg development | $118.05 |
Prices are for specific dosages and are sourced from Glen Shields Pharmacy as of September 2025 for comparison purposes only; they do not reflect U.S. pricing and are subject to change [1.3.8].
Navigating Insurance and Financial Assistance
Insurance coverage for fertility drugs like Gynatrop is inconsistent. Patients should contact their insurance provider directly to understand their policy's specific benefits, limitations, and requirements for prior authorization. For those without sufficient coverage, some pharmaceutical companies offer patient assistance programs (PAPs) or copay cards for their products, though this is more common for widely marketed drugs in the US and Europe. Researching these programs for the specific medication prescribed can sometimes lead to significant savings.
Potential Side Effects of Buserelin (Gynatrop)
Like all medications, Buserelin can cause side effects. Common side effects may include symptoms associated with low estrogen, such as hot flushes, increased sweating, and loss of libido [1.2.1]. Other potential side effects include headache, dizziness, nausea, injection site reactions, and mood changes [1.2.1, 1.6.8]. With long-term use, there may be a risk of decreased bone mineral density [1.2.1]. Patients should discuss all potential risks with their healthcare provider.
Conclusion
In summary, the question 'What is the cost of Gynatrop injection?' has a complex answer that is highly dependent on location. While it is an affordable medication in markets like India, the active ingredient, Buserelin, and comparable drugs are significantly more expensive in North America [1.2.8, 1.3.8]. The total cost of treatment is further influenced by dosage, insurance coverage, and pharmacy choice. Patients prescribed Gynatrop or any fertility medication should have a detailed discussion with their healthcare team and insurance provider to understand the full financial implications and explore all available options for managing costs. For more information on fertility treatments, one authoritative source is the American Society for Reproductive Medicine.
