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What is the difference between a cortisone shot and a plasma injection?

4 min read

According to the CDC, an estimated 53.2 million US adults have been diagnosed with a form of arthritis, with many seeking relief through injections. When considering treatment options for joint, muscle, or tendon pain, understanding the key distinction between a cortisone shot and a plasma injection is critical for effective management.

Quick Summary

Cortisone injections use a powerful anti-inflammatory steroid for rapid, temporary pain relief, while plasma (PRP) injections utilize the body's own healing factors for long-term tissue repair and regeneration.

Key Points

  • Mechanism of Action: A cortisone shot reduces inflammation to decrease pain, while a plasma injection (PRP) uses the body's growth factors to stimulate tissue repair and healing.

  • Speed vs. Longevity: Cortisone offers rapid, short-term relief, whereas PRP provides more gradual but sustained, long-term healing.

  • Source Material: Cortisone is a synthetic steroid medication, while PRP is created from the patient’s own blood.

  • Treatment Risks: PRP has minimal risk of allergic reaction since it's autologous, while cortisone can potentially damage surrounding tissues and impact blood sugar with repeated use.

  • Cost and Coverage: Cortisone shots are typically covered by insurance, but PRP therapy is often not, making it a more expensive option.

  • Best Use Cases: Cortisone is often used for immediate relief of inflammatory flare-ups, while PRP is preferred for chronic conditions that require long-term tissue regeneration.

In This Article

Understanding a Cortisone Shot

A cortisone shot, also known as a corticosteroid injection, delivers a potent synthetic steroid directly to a specific area of pain and inflammation. These injections mimic the effects of cortisol, a hormone naturally produced by the adrenal glands, but in a much more concentrated form. Cortisone does not address the underlying cause of the damage but rather works by suppressing the immune system's inflammatory response, which in turn reduces pain and swelling.

How Cortisone Shots Work

When injected into an inflamed joint, tendon, or bursa, the corticosteroids act quickly to calm the inflammation. This provides patients with significant, and often rapid, pain relief. The primary goal is to alleviate symptoms, allowing the patient to participate in physical therapy and other rehabilitation exercises more effectively.

Common Uses for Cortisone Shots

  • Osteoarthritis: Reducing joint pain and inflammation in knees, hips, and shoulders.
  • Tendinitis: Treating inflammation of tendons in areas like the elbow (tennis elbow) and shoulder.
  • Bursitis: Calming inflammation of the bursae, which are fluid-filled sacs that cushion joints.
  • Rheumatoid Arthritis: Managing flare-ups in patients with this autoimmune condition.

Pros and Cons of Cortisone Shots

Pros:

  • Fast-acting: Relief often begins within a few days.
  • Targeted relief: The medication is delivered directly to the problem area.
  • Widely available and covered by insurance: Generally more accessible and affordable than newer therapies.

Cons:

  • Temporary relief: Effects typically last for a few weeks to several months, but do not offer a permanent solution.
  • Potential for tissue damage: Repeated injections can weaken or damage tendons and cartilage.
  • Systemic side effects: Can cause temporary increases in blood sugar for diabetics and facial flushing.

Understanding a Plasma Injection (PRP)

A plasma injection, more commonly known as Platelet-Rich Plasma (PRP) therapy, is a type of regenerative medicine that uses a patient’s own blood to promote healing. The process involves drawing a small amount of the patient's blood, spinning it in a centrifuge to separate and concentrate the platelets, and then injecting this PRP into the injured tissue.

How PRP Injections Work

Unlike cortisone, which suppresses inflammation, PRP kickstarts the body's natural healing process. Platelets contain numerous growth factors that, when concentrated and re-injected, stimulate cellular growth, tissue regeneration, and healing. This approach aims to repair the underlying issue rather than just masking the symptoms.

Common Uses for PRP Injections

  • Chronic Tendon Injuries: Treating conditions like tennis elbow, Achilles tendinitis, and patellar tendinitis.
  • Osteoarthritis: Improving joint health and reducing pain, especially in the knee.
  • Ligament Injuries: Aiding in the healing of sprains and partial tears.
  • Post-Surgical Healing: Accelerating recovery after certain orthopedic surgeries.

Pros and Cons of PRP Injections

Pros:

  • Long-term healing: Promotes genuine tissue regeneration, offering more sustained relief.
  • Low risk of side effects: Made from the patient's own blood, minimizing the risk of allergic reactions.
  • Less reliance on medication: Can reduce or eliminate the need for anti-inflammatory medications.

Cons:

  • Slower results: It may take weeks or months to notice significant improvement as healing takes time.
  • Cost: Often not covered by insurance, making it a more expensive option.
  • Variable outcomes: Effectiveness can depend on the specific condition, patient health, and PRP preparation technique.

Comparison: Cortisone Shot vs. Plasma Injection

Feature Cortisone Shot Plasma (PRP) Injection
Mechanism Suppresses inflammation to relieve pain. Promotes and accelerates tissue healing and regeneration.
Primary Goal Short-term pain management and symptom relief. Long-term healing and tissue repair.
Onset of Action Fast, often within days. Slow, can take several weeks to months.
Duration of Effect Temporary, lasting weeks to months. Sustained, potentially lasting a year or more as the tissue heals.
Source Material Synthetic corticosteroid medication. Patient's own concentrated blood platelets.
Risks Temporary blood sugar spikes, tissue weakening, potential for cartilage damage with repeated use. Minimal risk, potential for soreness or bruising at the injection site.
Cost Often covered by insurance, more affordable out-of-pocket. Generally not covered by insurance, more expensive.

Choosing the Right Injection

The best choice depends on a patient's specific condition, goals, and timeline for recovery. A doctor's evaluation is essential for determining which treatment is most appropriate.

When to Consider a Cortisone Shot

  • Rapid Pain Relief is Needed: For acute injury flare-ups, a cortisone shot can quickly reduce debilitating pain.
  • Managing Chronic Conditions: In cases of severe inflammation from conditions like arthritis, it can provide effective, albeit temporary, relief.
  • Prepping for Rehabilitation: By reducing pain, it can enable a patient to begin or continue physical therapy that would otherwise be too painful.

When to Consider a Plasma Injection (PRP)

  • Promoting Long-Term Healing: For chronic issues where tissue repair is needed, PRP provides a regenerative solution.
  • Overuse Injuries: Particularly effective for chronic tendon injuries like tennis elbow where a focus on healing is important.
  • Avoiding Steroid Risks: A good option for patients who need to limit steroid exposure due to diabetes or concerns about potential tissue damage.

Combined or Staggered Approach

In some cases, a physician may recommend a staged approach. For instance, a cortisone shot could be used first to manage severe initial inflammation. Once the inflammation has subsided, a PRP injection can be administered to promote long-term healing.

Conclusion

While both cortisone shots and plasma injections can significantly improve pain and function for orthopedic issues, they employ fundamentally different approaches. A cortisone shot offers a potent anti-inflammatory medication for fast, short-term symptom relief, ideal for managing acute inflammatory episodes. In contrast, a plasma (PRP) injection harnesses the body's natural healing capabilities to promote long-term tissue regeneration, making it a more regenerative and restorative treatment. The optimal choice between the two is a personalized decision that should be made in consultation with a healthcare professional, considering the specific injury, patient goals, and desired treatment outcome.

For more detailed information on specific orthopedic conditions and treatments, you may consult resources like the Johns Hopkins Medicine health library.

Frequently Asked Questions

The primary difference lies in their mechanism: a cortisone shot acts as a strong anti-inflammatory to suppress symptoms, while a PRP injection stimulates the body's natural healing process to repair damaged tissue.

A cortisone shot provides faster pain relief, with many patients feeling significant relief within a few days of the injection. A PRP injection, which focuses on long-term healing, takes several weeks to months to show full effect.

A plasma (PRP) injection typically offers more long-lasting results because it promotes tissue regeneration, addressing the underlying cause of the pain. The effects of a cortisone shot are temporary and wear off over weeks or months.

Generally, PRP therapy is not covered by insurance and can be a more expensive out-of-pocket procedure. Cortisone shots, on the other hand, are typically covered.

Potential risks of cortisone shots include temporary increases in blood sugar, facial flushing, and, with repeated use, potential weakening or damage to surrounding tissues like cartilage and tendons.

Because PRP is made from your own blood, the risks are minimal, with the most common side effects being soreness, bruising, and minor pain at the injection site. There is a very low risk of infection.

The best choice depends on your specific condition and goals, and should be discussed with a doctor. If you need rapid, temporary relief for an acute flare-up, cortisone may be recommended. If you need long-term tissue repair for a chronic issue, PRP might be a better option.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.