What is Cova (Valsartan)?
Cova is a brand-name medication containing the active ingredient valsartan. As an angiotensin II receptor blocker (ARB), it works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. This action helps to relax and widen blood vessels, lowering blood pressure and reducing the heart's workload.
Valsartan is also available under other brand names, such as Diovan, and in generic forms. Combination products exist, such as Cova-H, which includes valsartan and a diuretic for more resistant hypertension.
Therapeutic Uses of Cova
Hypertension (High Blood Pressure)
Cova is commonly prescribed for hypertension. High blood pressure increases the risk of heart disease, stroke, and kidney issues. Cova helps lower blood pressure by relaxing blood vessels, protecting against these risks. The appropriate dosage is determined by a healthcare professional. Dosage may be adjusted or combined with other medications if needed.
Heart Failure
Cova treats heart failure, especially for patients who cannot take ACE inhibitors. It helps improve the heart's function and manages fluid retention. It can be used alongside other heart failure treatments like diuretics. Some monitoring systems, such as the Cova™ Monitoring System, have been explored for managing congestive heart failure.
Post-Myocardial Infarction
Cova can improve survival in clinically stable patients after a heart attack, particularly those with left ventricular failure. It aids the heart in pumping more effectively, improving long-term outcomes.
Side Effects and Contraindications
Like all medications, Cova can cause side effects.
Common Side Effects
- Dizziness or lightheadedness
- Fatigue
- Cough
- Headache
- Nausea or abdominal pain
- Hyperkalemia (high potassium levels)
Severe Side Effects and Contraindications
- Angioedema: Severe swelling of the face, lips, tongue, or throat.
- Pregnancy: Contraindicated due to risk of harm to the fetus.
- Kidney or Liver Disease: Use with caution; contraindicated in severe liver impairment.
- Drug Interactions: Can interact with medications like lithium, NSAIDs, and potassium-sparing diuretics.
The Valsartan Recall History
A major recall of valsartan-containing medications began in 2018 due to the presence of N-nitrosodimethylamine (NDMA), a probable human carcinogen, from certain suppliers. The FDA and international agencies coordinated the recall. Not all valsartan products were affected. Patients were advised to consult their doctor for replacement medication rather than stopping treatment abruptly.
This recall has resulted in numerous lawsuits against manufacturers, with multidistrict litigation ongoing in federal court.
Cova vs. Other Common ARBs: A Comparison
Here is a comparison of Cova (valsartan) with another ARB, losartan (Cozaar):
| Feature | Cova (Valsartan) | Cozaar (Losartan) |
|---|---|---|
| Primary Uses | Hypertension, heart failure, post-myocardial infarction | Hypertension, stroke risk reduction, slowing kidney disease in diabetes |
| Dosage Frequency | Varies based on medical condition and individual needs | Varies based on medical condition and individual needs |
| Pediatric Use | Approved for children 1 year and older for hypertension | Approved for children 6 years and older for hypertension |
| Available Forms | Tablet (and combination products) | Tablet |
| Side Effects | Dizziness, fatigue, hyperkalemia, angioedema | Dizziness, fatigue, hyperkalemia |
| Recall History | Some brands recalled due to NDMA contamination | Some brands also recalled due to similar contaminants |
Combination Medications
Valsartan is available in combination with other drugs:
- Cova-H: Contains valsartan and hydrochlorothiazide (a diuretic).
- Covam: Contains valsartan and amlodipine (a calcium channel blocker).
Conclusion
Cova (valsartan) is a crucial medication for hypertension, heart failure, and post-heart attack complications. Patients and healthcare providers should be aware of its side effects and interactions. The valsartan recall highlights the need for careful manufacturing and communication. Patients on valsartan should verify their medication was not recalled and consult their doctor with concerns. More information on valsartan is available from resources like MedlinePlus.
MedlinePlus: Valsartan Information
Disclaimer: This information is for general knowledge and should not be taken as medical advice. Consult with a healthcare professional before starting any new supplement regimen.
