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What is the drug Deramax used for?

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6 min read

Over 60% of dogs with musculoskeletal disorders showed improvement within 7 days of starting treatment with deracoxib. Deramax, whose active ingredient is deracoxib, is a common prescription non-steroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation in dogs.

Quick Summary

Deramax, or deracoxib, is a non-steroidal anti-inflammatory drug (NSAID) prescribed by veterinarians for dogs. It is primarily used to manage the pain and inflammation associated with canine osteoarthritis and to control post-surgical discomfort following orthopedic and dental procedures.

Key Points

  • Osteoarthritis Management: Deramax is a prescription non-steroidal anti-inflammatory drug (NSAID) primarily used in dogs to control the pain and inflammation associated with osteoarthritis.

  • Post-Surgical Pain Control: It is also prescribed to manage post-operative pain and inflammation following orthopedic and dental surgeries in dogs.

  • Selective COX-2 Inhibitor: Deramax works by selectively blocking the COX-2 enzyme, which is responsible for inflammation, while minimizing the inhibition of the beneficial COX-1 enzyme.

  • Potential Side Effects: Common side effects include gastrointestinal upset, such as vomiting, diarrhea, and decreased appetite, while serious risks can involve the liver or kidneys.

  • Veterinary Supervision Required: Use of Deramax requires a veterinary prescription, and regular monitoring through physical exams and bloodwork is recommended, especially for long-term use.

  • Not for Cats: The medication is only approved for use in dogs and is toxic to cats.

  • Drug Interactions: It should not be used in conjunction with other NSAIDs or corticosteroids, as this significantly increases the risk of adverse reactions.

In This Article

Deramax, known generically as deracoxib, is a selective non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in dogs. It belongs to the 'coxib' class of drugs, which target specific enzymes responsible for pain and inflammation. While not a cure for chronic conditions like osteoarthritis, Deramax effectively manages symptoms to improve a dog's comfort.

How Deramax Works: Selective COX-2 Inhibition

NSAIDs function by inhibiting COX enzymes, which produce prostaglandins that cause inflammation, pain, and fever. Deramax is a selective COX-2 inhibitor, primarily targeting the enzyme involved in inflammation. By largely sparing the COX-1 enzyme, which is vital for normal bodily functions like protecting the stomach lining and kidney health, Deramax aims to reduce pain and inflammation with a potentially lower risk of gastrointestinal side effects compared to non-selective NSAIDs.

Primary Uses for Deramax

Veterinarians prescribe Deramax mainly for two conditions in dogs:

  • Osteoarthritis (OA): This degenerative joint disease causes chronic pain and stiffness. Deramax provides long-term management of these symptoms to improve mobility and quality of life for dogs with OA.
  • Postoperative Pain and Inflammation: Deramax is used to control pain and inflammation after surgeries, particularly orthopedic or dental procedures. A higher dosage may be used for a limited time post-surgery as determined by a veterinarian.

Dosage and Administration

Deramax is available as a chewable, beef-flavored tablet, making it easy to give to dogs. The specific amount administered varies based on the condition being treated and the dog's individual needs as determined by a veterinarian.

Giving Deramax with food can help reduce stomach upset. Tablets are scored for easier administration, but ensuring the correct amount for very small pets requires careful measurement and veterinary guidance.

Potential Side Effects

Like any medication, Deramax can cause side effects. Owners should be aware of potential reactions, from mild to severe.

Common Side Effects:

  • Vomiting
  • Loss of appetite
  • Diarrhea
  • Tiredness

Serious Adverse Reactions (contact your vet immediately):

  • Bloody, black, or tarry stools (indicating possible gastrointestinal ulceration)
  • Increased drinking or urination
  • Yellowing of gums, skin, or eyes (jaundice)
  • Changes in coordination or seizures
  • Signs of kidney or liver issues

A Comparison of Common Canine NSAIDs

Veterinarians consider several factors when choosing an NSAID for a dog. Here's how Deramax compares to other common options:

Feature Deramax (Deracoxib) Rimadyl (Carprofen) Previcox (Firocoxib)
Mechanism Selective COX-2 inhibitor Selective COX-2 inhibitor Highly selective COX-2 inhibitor
Primary Uses OA and postoperative pain OA and postoperative pain OA and postoperative pain
Administration Once-daily, chewable tablet Oral tablets or injectable Once-daily, chewable tablet
Common Side Effects GI upset (vomiting, diarrhea, anorexia) GI upset (vomiting, diarrhea), liver and kidney issues GI upset (vomiting, diarrhea), liver and kidney issues
Monitoring Recommended before and during long-term use Recommended, especially for long-term use Recommended, especially for long-term use

Important Precautions and Monitoring

Deramax requires a veterinarian's prescription and supervision. Pre-treatment exams and bloodwork are important, especially for long-term use, to check liver and kidney function.

Key warnings:

  • Do not use in cats. Deramax is toxic to cats and is approved for dogs only.
  • Avoid other NSAIDs or steroids. Using Deramax with other NSAIDs or corticosteroids increases the risk of serious side effects.
  • Monitor your dog. Owners should watch for any adverse reactions and contact their vet immediately if concerns arise.

Conclusion

Deramax is a prescription NSAID used for managing pain and inflammation in dogs with osteoarthritis or post-surgical discomfort. Its selective action offers potential benefits, but it's vital to follow veterinary instructions, monitor for side effects, and avoid combining it with other anti-inflammatory drugs. Regular vet visits are crucial to ensure safe and effective use, helping your dog live more comfortably.

For more information on NSAID use in dogs, consult the Food and Drug Administration's guidance for veterinarians.

Keypoints

  • Osteoarthritis Management: Deramax is a prescription non-steroidal anti-inflammatory drug (NSAID) primarily used in dogs to control the pain and inflammation associated with osteoarthritis.
  • Post-Surgical Pain Control: It is also prescribed to manage post-operative pain and inflammation following orthopedic and dental surgeries in dogs.
  • Selective COX-2 Inhibitor: Deramax works by selectively blocking the COX-2 enzyme, which is responsible for inflammation, while minimizing the inhibition of the beneficial COX-1 enzyme.
  • Potential Side Effects: Common side effects include gastrointestinal upset, such as vomiting, diarrhea, and decreased appetite, while serious risks can involve the liver or kidneys.
  • Veterinary Supervision Required: Use of Deramax requires a veterinary prescription, and regular monitoring through physical exams and bloodwork is recommended, especially for long-term use.
  • Not for Cats: The medication is only approved for use in dogs and is toxic to cats.
  • Drug Interactions: It should not be used in conjunction with other NSAIDs or corticosteroids, as this significantly increases the risk of adverse reactions.

Faqs

What is the active ingredient in Deramax? The active ingredient in Deramax is deracoxib, a selective non-steroidal anti-inflammatory drug (NSAID).

Can Deramax be used for cats? No, Deramax is approved and safe for use in dogs only and is not recommended for cats, as it can be toxic to them.

Is Deramax given with or without food? It is preferable to give Deramax with food to reduce the potential for gastrointestinal side effects, though it can be given on an empty stomach if necessary.

What should I do if my dog vomits after taking Deramax? If your dog exhibits signs of gastrointestinal upset like vomiting, you should stop administering the medication and contact your veterinarian immediately for guidance.

How does Deramax differ from other NSAIDs? Deramax is a selective COX-2 inhibitor, which means it targets the inflammatory pathway more specifically than some older, non-selective NSAIDs, potentially leading to fewer gastrointestinal side effects at therapeutic dosages determined by a veterinarian.

Are there any long-term risks with Deramax? Long-term use requires regular monitoring with blood tests to check for potential liver or kidney problems, though serious side effects are rare. The lowest effective amount determined by a veterinarian should always be used.

What are the signs of a serious reaction to Deramax? Signs of a serious reaction can include bloody, black, or tarry stools, yellowing of the skin or eyes (jaundice), increased thirst or urination, and significant behavioral changes.

Can Deramax be combined with other medications? Deramax should not be given with other NSAIDs or corticosteroids. You must inform your veterinarian of all medications your dog is taking to prevent potential drug interactions.

Citations

Frequently Asked Questions

The active ingredient in Deramax is deracoxib, a selective non-steroidal anti-inflammatory drug (NSAID).

No, Deramax is approved and safe for use in dogs only and is not recommended for cats, as it can be toxic to them.

It is preferable to give Deramax with food to reduce the potential for gastrointestinal side effects, though it can be given on an empty stomach if necessary.

If your dog exhibits signs of gastrointestinal upset like vomiting, you should stop administering the medication and contact your veterinarian immediately for guidance.

Deramax is a selective COX-2 inhibitor, which means it targets the inflammatory pathway more specifically than some older, non-selective NSAIDs, potentially leading to fewer gastrointestinal side effects at therapeutic dosages determined by a veterinarian.

Long-term use requires regular monitoring with blood tests to check for potential liver or kidney problems, though serious side effects are rare. The lowest effective amount determined by a veterinarian should always be used.

Signs of a serious reaction can include bloody, black, or tarry stools, yellowing of the skin or eyes (jaundice), increased thirst or urination, and significant behavioral changes.

Deramax should not be given with other NSAIDs or corticosteroids. You must inform your veterinarian of all medications your dog is taking to prevent potential drug interactions.

References

  1. 1
    Deracoxib | VCA Animal Hospitals
  2. 2
    Deramaxx Client Information Sheet and Package Insert
  3. 3
    Deramaxx (Deracoxib)for Dogs: Uses, Dosage, Side Effects | GoodRx
  4. 4
    Deracoxib - Wikipedia
  5. 5
    Deracoxib (Deramaxx®) - Reseda Pharmacy
  6. 6
    Deramaxx® | Flexible canine OA treatment - Elanco
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    Deracoxib (Deramaxx), Canine - Healthy Paws Animal Hospital
  8. 8
    What Veterinarians Should Advise Clients About Pain Control ...
  9. 9
    Field Comparison of Canine NSAIDs Firocoxib and Deracoxib. | JARVM
  10. 10
    Deramaxx™ (deracoxib) - PetMD
  11. 11
    Deramaxx | Pet Medicine Info - Hastings Veterinary Hospital
  12. 12
    Deramaxx for Dogs: Uses, Dosage, Side Effects - Drugs.com

Related Topics:

#osteoarthritis #Postoperative Pain #Veterinary Medication #canine arthritis #NSAID for Dogs #Deramax #Deracoxib #dog pain relief

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.