What Is Linezolid?
Linezolid is a synthetic antibacterial agent belonging to the oxazolidinone class. This class has a unique mechanism of action effective against bacteria, including resistant strains. Approved in 2000, it's considered a critically important medication.
How Linezolid Works
Linezolid targets bacterial protein synthesis. It binds to the 23S ribosomal RNA of the 50S subunit, preventing the formation of the 70S initiation complex needed for protein synthesis. This action can be bacteriostatic or bactericidal depending on the bacterial strain.
Uses and Indications for Linezolid
Linezolid treats serious bacterial infections, including drug-resistant strains. Indications include Vancomycin-Resistant Enterococcus (VRE) infections (with or without bacteremia), nosocomial pneumonia (including MRSA), community-acquired pneumonia (S. pneumoniae and MRSA), and complicated skin and skin structure infections (cSSSI) like diabetic foot infections and MRSA infections.
Potential Side Effects
Linezolid can cause side effects, more common with long-term use (over 28 days). Common side effects include headache, nausea, vomiting, diarrhea, taste changes, and decreased blood cell counts. Serious side effects can include myelosuppression, peripheral and optic neuropathy (with long-term therapy), serotonin syndrome (especially with other serotonergic drugs), and lactic acidosis.
Drug and Food Interactions
As a weak monoamine oxidase inhibitor (MAOI), linezolid interacts with certain medications and foods. Serotonergic agents can increase the risk of serotonin syndrome. Sympathomimetic agents may have an enhanced effect. Avoiding large amounts of tyramine-rich foods is recommended to prevent increased blood pressure.
Comparison of Linezolid and Arlin
Arlin and generic linezolid are therapeutically equivalent. Differences are mainly in manufacturer, cost, and marketing.
Feature | Arlin 600 mg | Linezolid (Generic) |
---|---|---|
Active Ingredient | Linezolid | Linezolid |
Drug Class | Oxazolidinone Antibiotic | Oxazolidinone Antibiotic |
Cost | Typically higher, as a brand-name drug | Often significantly lower than brand-name version |
Availability | Availability depends on market and brand; Arlin is marketed by Beximco Pharmaceuticals | Available from various manufacturers, offering wider generic availability |
Formulation | Available in tablets, IV infusion, and oral suspension | Available in tablets, IV infusion, and oral suspension |
Bioavailability | 100% oral bioavailability, meaning IV-to-oral switch is seamless | 100% oral bioavailability, a key pharmacokinetic advantage |
Indication | Treats severe bacterial infections | Treats severe bacterial infections |
Conclusion
The generic name for Arlin 600 mg is linezolid, a potent oxazolidinone antibiotic. It is primarily used for severe, often resistant, bacterial infections and works by inhibiting bacterial protein synthesis initiation. While generally safe for short-term use, it's important to be aware of side effects and drug/food interactions. Generic linezolid, being therapeutically equivalent, offers an affordable and accessible option.
To learn more about this medication and other drug information, consult the MedlinePlus drug database.