What is the generic version of Dexedrine?
Dexedrine is the brand name for the prescription drug dextroamphetamine sulfate. Therefore, the generic version of Dexedrine is simply dextroamphetamine. Both the generic and brand-name versions are central nervous system (CNS) stimulants primarily prescribed to treat Attention-Deficit/Hyperactivity Disorder (ADHD) and narcolepsy.
Dextroamphetamine works by increasing the levels of certain neurotransmitters, namely dopamine and norepinephrine, in the brain. This increase in chemical activity helps improve a person's ability to focus, pay attention, and control impulses. While the generic version is chemically and therapeutically equivalent to the brand-name product, the main differences lie in cost and inactive ingredients.
Generic vs. brand-name Dexedrine
For a generic drug to be approved by the U.S. Food and Drug Administration (FDA), it must prove to be bioequivalent to its brand-name counterpart. This means it must contain the same active ingredient, strength, dosage form, and route of administration, and it must work the same way in the body.
Key distinctions
Despite being therapeutically equivalent, a few minor distinctions exist between generic and brand-name medications. These differences can be important for some patients, particularly those with sensitivities to certain inactive ingredients.
Here is a comparison table outlining the key differences and similarities:
| Feature | Generic Dextroamphetamine | Brand-Name Dexedrine |
|---|---|---|
| Active Ingredient | Dextroamphetamine sulfate | Dextroamphetamine sulfate |
| Efficacy | Therapeutically equivalent | Therapeutically equivalent |
| Cost | Typically significantly lower | Generally higher |
| Inactive Ingredients | May vary by manufacturer | Standardized by original manufacturer |
| Appearance | Varies (shape, color, markings) | Standardized appearance (e.g., color, markings) |
Some patients perceive a difference in effectiveness between generic and brand-name versions, though this is not supported by bioequivalence testing. Variations in inactive ingredients like fillers and binders, or even psychological factors, can sometimes lead to different experiences. If you feel the generic version is not working as well for you, discuss it with your healthcare provider.
Dextroamphetamine formulations
Dextroamphetamine is available in both immediate-release and extended-release formulations, which affects how quickly the medication enters the bloodstream and how long its effects last.
- Immediate-release (IR) tablets and oral solution: These formulations are typically taken two to three times per day. The effects are more immediate but shorter-lasting, typically for 4 to 6 hours.
- Extended-release (ER) capsules (Spansules): This long-acting formulation is taken once daily in the morning and is designed to provide a steady release of the medication throughout the day, with effects lasting up to 8 to 10 hours.
In addition to the generic forms, dextroamphetamine is also marketed under other brand names, including ProCentra, Zenzedi, and Xelstrym. Your healthcare provider will determine the most appropriate formulation and brand for your specific needs.
Cost and availability
One of the most significant advantages of opting for generic dextroamphetamine over brand-name Dexedrine is the cost savings. Generic versions are often substantially cheaper due to the lack of research and development costs incurred by the original brand-name drug manufacturer.
- Insurance coverage: Most Medicare and commercial insurance plans cover generic dextroamphetamine.
- Pharmacy coupons and discount cards: For patients without insurance, or for those whose plans have high deductibles, discount programs like GoodRx offer significant savings, with cash prices often much lower than the average retail cost.
Side effects and safety considerations
As a controlled substance, dextroamphetamine has a high potential for abuse and dependence, and misuse can lead to serious health complications or death. Therefore, it is crucial to take this medication exactly as prescribed.
Common side effects
- Decreased appetite and weight loss
- Dry mouth
- Insomnia
- Nervousness or restlessness
- Headache
- Dizziness
- Increased heart rate
Serious side effects and warnings
- Cardiovascular issues: Stimulants can increase blood pressure and heart rate. Serious problems, including sudden death, have been reported in patients with pre-existing heart conditions.
- Psychiatric problems: Dextroamphetamine can cause or worsen mental health issues, including psychosis, aggression, or mania.
- Circulation problems: Raynaud's phenomenon, a condition causing numbness or pain in the fingers and toes, can occur.
- Growth suppression: Long-term use in children may lead to a temporary slowing of growth.
Patients should discuss their full medical history with their doctor before starting treatment, especially if they have a history of heart problems, mental illness, or substance abuse.
Conclusion
For many patients requiring dextroamphetamine for conditions like ADHD or narcolepsy, the generic version offers a safe and effective alternative to brand-name Dexedrine. While both contain the same active ingredient and produce the same therapeutic effects, generic dextroamphetamine is typically a more affordable option. Patients should consult their healthcare provider to determine if the generic version is the right choice for them, taking into account cost, potential side effects, and specific formulation needs. Always follow your doctor's instructions carefully to ensure the medication is used safely and effectively.
Visit the MedlinePlus Dextroamphetamine page for more detailed drug information.
