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What is the most commonly used psychotropic drug in the US?

3 min read

In 2023, sertraline hydrochloride was the most dispensed antidepressant, accounting for 16.73% of total prescriptions in its class [1.2.1]. This highlights a significant trend in mental health treatment, but what is the most commonly used psychotropic drug in the US overall?

Quick Summary

The most prescribed class of psychotropic drugs in the US is antidepressants, with sertraline (Zoloft) consistently ranking as the most dispensed medication for mental health conditions.

Key Points

  • Top Drug Class: Antidepressants are the most frequently prescribed category of psychotropic medications in the U.S. [1.2.3].

  • Most Common Drug: Sertraline (Zoloft), an SSRI antidepressant, is the most commonly prescribed single psychotropic drug [1.2.1, 1.2.2].

  • Prevalence: Roughly 1 in 6 adults in the U.S. reports using at least one psychotropic medication [1.2.4].

  • How SSRIs Work: Sertraline functions by increasing the availability of serotonin, a neurotransmitter that regulates mood [1.6.3].

  • Other Major Classes: Other common classes include anti-anxiety drugs (anxiolytics), antipsychotics, mood stabilizers, and stimulants [1.6.2].

  • Growing Use: Prescription rates for antidepressants have significantly increased, especially among adolescents and young adults [1.4.5].

  • Safety Profile: SSRIs like sertraline are often preferred over older antidepressants due to having fewer side effects [1.2.1].

In This Article

Understanding Psychotropic Medications

Psychotropic drugs are a broad category of substances that alter brain chemistry to affect mood, thoughts, perceptions, and behavior [1.3.2, 1.6.4]. They are primarily prescribed to manage a wide array of mental health conditions, from depression and anxiety to psychosis and bipolar disorder [1.3.2, 1.6.4]. These medications are typically categorized into five main types: antidepressants, anti-anxiety agents, antipsychotics, mood stabilizers, and stimulants [1.6.2, 1.6.3]. Each class works through different mechanisms on the brain's neurotransmitters—such as serotonin, dopamine, and norepinephrine—to help restore chemical balance and alleviate symptoms [1.6.4].

The Leading Class and Drug: Antidepressants and Sertraline

Across the United States, antidepressants are the most frequently prescribed category of psychotropic medications [1.2.3]. Statistics consistently show that a significant portion of the population uses these drugs. For instance, studies indicate that about 1 in 6 Americans takes a psychiatric medication, with antidepressants being the most common type [1.2.4, 1.2.5].

Within this large class, the selective serotonin reuptake inhibitor (SSRI) sertraline (brand name Zoloft) is consistently identified as the most commonly prescribed psychotropic medication in the U.S. [1.2.2, 1.4.3]. In 2023, sertraline hydrochloride alone accounted for over 16% of all antidepressant prescriptions dispensed [1.2.1]. Its popularity stems from its effectiveness and that SSRIs generally have fewer side effects compared to older classes of antidepressants like tricyclics [1.2.1]. Following sertraline, other frequently prescribed antidepressants include trazodone, fluoxetine (Prozac), and escitalopram (Lexapro) [1.2.1]. In 2022, there were nearly 40 million prescriptions for sertraline in the U.S. [1.4.1].

How Common Psychotropics Work

  • Antidepressants (SSRIs): Selective serotonin reuptake inhibitors like sertraline work by increasing the levels of serotonin, a neurotransmitter linked to mood, in the brain [1.6.3]. They block the reabsorption (reuptake) of serotonin into neurons, making more of it available to improve signal transmission between neurons [1.6.2].
  • Anti-anxiety Medications (Anxiolytics): This class includes benzodiazepines like alprazolam (Xanax) and clonazepam (Klonopin). They enhance the effect of the neurotransmitter GABA, which results in a calming or sedative effect [1.6.4]. They are typically fast-acting but are often recommended for short-term use due to the risk of dependence [1.5.3, 1.5.4].
  • Antipsychotics: Divided into typical (first-generation) and atypical (second-generation), these drugs primarily block dopamine receptors to manage symptoms of psychosis like hallucinations and delusions [1.6.4]. Atypical antipsychotics, such as aripiprazole (Abilify), also affect serotonin receptors [1.6.2].
  • Stimulants: Medications like methylphenidate (Ritalin) and amphetamine/dextroamphetamine (Adderall) are used to treat ADHD. They increase levels of dopamine and norepinephrine, which can improve focus and alertness [1.6.3].

Comparison of Top Psychotropic Drug Classes

Feature Antidepressants (SSRIs) Anti-Anxiety (Benzodiazepines) Antipsychotics (Atypical)
Primary Use Depression, Anxiety Disorders [1.6.3] Short-term anxiety, Panic attacks [1.5.4] Schizophrenia, Bipolar Disorder, Psychosis [1.6.2]
Example Drugs Sertraline (Zoloft), Escitalopram (Lexapro) [1.6.2] Alprazolam (Xanax), Clonazepam (Klonopin) [1.2.4] Aripiprazole (Abilify), Quetiapine (Seroquel) [1.6.6]
Mechanism Increases serotonin levels [1.6.2] Enhances effects of GABA [1.6.4] Blocks dopamine and/or serotonin receptors [1.6.4]
Onset of Action Takes several weeks to become effective [1.5.3] Fast-acting (within hours) [1.5.4] Varies; can take days to weeks
Common Side Effects Nausea, insomnia, sexual dysfunction, headache [1.5.1, 1.5.2] Drowsiness, dizziness, confusion, memory problems [1.5.3, 1.5.4] Weight gain, metabolic changes, drowsiness [1.6.4]
Dependence Risk Low; not considered addictive [1.5.5] High; risk of physical dependence and withdrawal [1.5.3] Low dependence risk, but can have severe side effects [1.6.2]

Trends in Psychotropic Medication Use

The use of psychotropic medications, particularly antidepressants, has seen a steady increase. Between 2016 and 2022, the monthly antidepressant dispensing rate for adolescents and young adults (ages 12-25) rose by 66.3% [1.4.5]. This trend is driven by multiple factors, including greater public awareness of mental health issues, reduced stigma surrounding treatment, and increased access to healthcare. While antidepressants and stimulants are the most common classes used by adolescents [1.7.1], a significant number of adults across all age groups rely on these medications for long-term management of mental health conditions [1.2.4].

Conclusion

Based on extensive prescription data, antidepressants are the most utilized class of psychotropic medication in the United States, with the SSRI sertraline (Zoloft) being the single most prescribed drug [1.2.1, 1.2.2]. The widespread use of sertraline and other SSRIs underscores their role as a first-line treatment for depression and anxiety due to their favorable side-effect profile compared to older medications [1.2.1]. The continued growth in psychotropic prescriptions reflects a major shift in how mental health is perceived and treated in the U.S.

For more information from an authoritative source, you can visit the National Institute of Mental Health (NIMH).

Frequently Asked Questions

Sertraline, an antidepressant often sold under the brand name Zoloft, is the most prescribed psychiatric medication in the United States [1.2.2, 1.4.3].

The five main types are antidepressants, anti-anxiety medications, stimulants, antipsychotics, and mood stabilizers [1.6.2, 1.6.3].

Yes, sertraline is a type of antidepressant known as a Selective Serotonin Reuptake Inhibitor (SSRI) [1.4.1].

Antidepressants, like SSRIs, are often used for long-term treatment of depression and anxiety and can take weeks to work [1.5.3]. Some anti-anxiety medications, like benzodiazepines, are fast-acting and used for short-term relief of severe anxiety or panic attacks but carry a risk of dependence [1.5.4].

Yes, data shows a significant increase in the dispensing of psychotropic medications, particularly antidepressants, among adolescents and young adults in recent years [1.4.5].

Common side effects of SSRIs like sertraline can include nausea, insomnia, headache, diarrhea, and drowsiness [1.5.2].

Benzodiazepines, a class of anti-anxiety medications, have a known risk for physical dependence and are not recommended for continuous long-term use [1.5.3, 1.6.2]. Stimulants also carry a risk of abuse and misuse [1.6.2].

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.