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What Is the Most Used Drug in the US?

4 min read

According to the Substance Abuse and Mental Health Services Administration (SAMHSA), in 2022, approximately 177 million Americans reported past-year alcohol use. Defining what is the most used drug in the US is complex, as the answer depends on whether you consider overall usage, prescription medications, or over-the-counter products.

Quick Summary

The most widely used drug in the US by population is alcohol, followed by nicotine and marijuana. Prescription medications and over-the-counter drugs are also widely prevalent, treating a range of health conditions.

Key Points

  • Alcohol is the most used drug overall: With millions of Americans reporting past-year use, alcohol is the most widely consumed substance across the US.

  • Nicotine and marijuana are next in line: Nicotine (via tobacco/vaping) and marijuana follow alcohol as the most prevalent substances used by the general population.

  • Prescription drugs for chronic conditions are widespread: Common prescriptions like Levothyroxine (thyroid), Atorvastatin (cholesterol), and Lisinopril (blood pressure) are among the most frequently dispensed.

  • Over-the-counter medications are regularly used: OTC drugs such as acetaminophen for pain and loratadine for allergies are relied upon by millions for day-to-day ailments.

  • Usage patterns vary by age: Data from the CDC shows that the most commonly used types of prescription drugs vary significantly across different age groups.

  • Drug regulation affects usage: The distinction between legal, illicit, and regulated medical products (prescription and OTC) is crucial to understanding prevalence and risk factors.

In This Article

Understanding the Most Used Drug in the US

Determining what is the most used drug in the US is not a simple question with a single answer. It requires distinguishing between different categories of substances, including legal recreational drugs, illegal substances, and both prescription and over-the-counter (OTC) medications. By examining data from various health organizations, a clearer, multi-faceted picture emerges of the most widely used substances in the country.

Alcohol: The Most Consumed Drug Overall

By a significant margin, alcohol is the most widely used psychoactive substance in the United States. The Substance Abuse and Mental Health Services Administration (SAMHSA) regularly conducts the National Survey on Drug Use and Health (NSDUH), which provides detailed statistics on substance use. According to their 2022 report, over 176 million Americans aged 12 or older reported using alcohol in the past year. Its pervasive presence in social settings and cultural norms contributes to its widespread consumption. Despite its legal status, alcohol use disorder remains a significant public health issue, affecting millions of adults.

Nicotine and Marijuana: The Next Most Prevalent

Following alcohol, nicotine ranks as the second most used drug in the US. Primarily consumed through tobacco products like cigarettes and vaping devices, nicotine has a broad user base. While smoking rates have decreased over time, the rise of vaping has contributed to sustained nicotine use, especially among younger adults.

Marijuana is another highly used drug, and its legal status continues to evolve across different states. The 2022 NSDUH report indicated that over 61 million Americans used marijuana in the past year, making it the most commonly used illicit substance on a federal level. However, its increasing legalization for medical and recreational purposes complicates its classification and impact on public health.

The Landscape of Most Prescribed Medications

While alcohol, nicotine, and marijuana top the list for overall usage, a different set of drugs dominate the prescription market. Many of these medications treat common, chronic conditions, indicating the widespread health challenges faced by the US population.

Some of the most frequently filled prescriptions in recent years include:

  • Levothyroxine (Synthroid): A synthetic thyroid hormone used to treat hypothyroidism, a condition where the thyroid gland does not produce enough hormone.
  • Atorvastatin (Lipitor): A statin medication used to lower cholesterol and prevent cardiovascular disease.
  • Lisinopril (Prinivil, Zestril): An ACE inhibitor for treating high blood pressure and heart failure.
  • Metformin (Glucophage): An oral medication for managing type 2 diabetes.
  • Albuterol (Ventolin, Proair): A bronchodilator used to treat asthma and other respiratory conditions.

These medications reflect the high prevalence of chronic diseases like heart disease, diabetes, and thyroid disorders, particularly among older adults.

Most Common Over-the-Counter Drugs

Beyond prescriptions, millions of Americans rely on easily accessible over-the-counter (OTC) medications for a variety of everyday ailments. These include:

  • Pain Relievers: Acetaminophen (Tylenol), ibuprofen (Advil, Motrin), and naproxen are among the most used OTC drugs for relieving pain and fever.
  • Allergy Medications: Antihistamines like loratadine (Claritin) and diphenhydramine (Benadryl) are widely used for seasonal and chronic allergies.
  • Stomach Acid Reducers: Omeprazole (Prilosec) is a proton pump inhibitor frequently purchased to treat heartburn and indigestion.
  • Cough and Cold Medicine: Products containing ingredients like dextromethorphan and pseudoephedrine are popular for managing coughs and congestion.

Comparison of Most Used Drug Categories

Drug Category Primary Examples Usage Metrics Primary Medical Use Public Health Considerations
Overall (Legal) Alcohol, Nicotine Most widely used substances by population. N/A (Recreational) High rates of addiction, liver disease, cancer, and other chronic illnesses.
Illicit Marijuana, Cocaine Marijuana is the most used illicit drug. Varies (Some states allow medicinal marijuana) Addiction, mental health issues, overdose risk (especially with illicit substances like fentanyl-laced cocaine).
Prescription Levothyroxine, Atorvastatin Counted by number of prescriptions filled. Treat chronic conditions (hypothyroidism, high cholesterol, etc.) Misuse potential for some classes (e.g., opioids), compliance for chronic disease management.
Over-the-Counter Acetaminophen, Ibuprofen Measured by sales and consumer use data. Relieve pain, fever, allergy symptoms, stomach issues Overuse risks, potential for hidden ingredients, drug interactions.

The Influence of Lifestyle and Chronic Conditions

Recent data from sources like the CDC highlights how prescription drug use is often tied to age and chronic illness. For example, lipid-lowering drugs are most common among adults aged 60 and over, while antidepressants are more prevalent in the 20-59 age group. These statistics reveal that while recreational substances are used across many demographics, a significant portion of pharmaceutical usage is driven by the management of long-term health issues. The rise of certain prescription drugs in spending, like Semaglutide for diabetes and weight loss, also reflects evolving health trends.

Access and Regulation Differences

Different types of drugs have vastly different access points and regulatory structures. Legal substances like alcohol and nicotine are sold under specific age restrictions, while illicit drugs are completely unregulated on the federal level. Prescription drugs are tightly controlled by the FDA and require a healthcare provider's authorization, while OTC medications are deemed safe enough for purchase without a prescription, provided they follow federal guidelines. This regulatory environment profoundly shapes patterns of use and associated health risks.

Conclusion

While a direct answer to what is the most used drug in the US is complex, it's clear that alcohol is the most widely consumed substance by a large margin. However, in a medical context, prescription drugs for common chronic conditions, like Levothyroxine and Atorvastatin, are incredibly widespread. Over-the-counter mainstays such as acetaminophen are also used by millions for symptom relief. Understanding the full scope of drug use in the United States requires looking beyond a single substance and considering the different types of drugs and their varied roles in American life.

For more detailed statistics on substance use, you can refer to the National Survey on Drug Use and Health (NSDUH) reports from SAMHSA.

Frequently Asked Questions

The most widely used legal drug in the United States is alcohol, with millions of Americans reporting recent use.

Marijuana is the most commonly used illicit drug at the federal level, with over 61 million people reporting past-year use in 2022, according to SAMHSA.

Some of the most commonly prescribed drugs in the US include Levothyroxine for thyroid issues, Atorvastatin for high cholesterol, and Lisinopril for high blood pressure.

Commonly used over-the-counter (OTC) drugs include pain relievers like acetaminophen (Tylenol) and ibuprofen (Advil), allergy medications, and heartburn medication like omeprazole (Prilosec).

While not often classified with substances like alcohol or illicit drugs, caffeine is the most widely used psychoactive substance globally. It is integrated into daily routines via coffee, tea, and other products, and can create dependence.

Yes, prescription and recreational drug use trends can change over time due to shifts in healthcare needs, evolving social perceptions, and drug availability. For example, prescription data shows variations in the most filled prescriptions year over year.

Different types of drugs are regulated differently. Legal substances like alcohol have specific age limits. Illicit drugs are illegal at the federal level. Prescription drugs are regulated by the FDA and require a doctor's authorization, while OTC drugs are approved for public use without a prescription.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.