What is Voltaren Used for Inflammation? A Comprehensive Guide

October 7, 2025 •

4 min read

Over-the-counter Voltaren Arthritis Pain Gel is the #1 doctor-recommended topical pain relief brand for arthritis. Its active ingredient, diclofenac, is a potent anti-inflammatory agent used to relieve joint pain and swelling, directly addressing the question: What is Voltaren used for inflammation?

Quick Summary

Voltaren, a medication containing the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, is used to treat inflammation and pain from conditions like osteoarthritis and rheumatoid arthritis. It works by reducing prostaglandins, offering localized relief through topical application or systemic effects via oral forms.

Key Points

Active Ingredient: Voltaren's active ingredient is diclofenac, a nonsteroidal anti-inflammatory drug (NSAID).
Mechanism: It works by blocking prostaglandin production, which reduces the chemicals that cause pain and inflammation.
Topical Use: The over-the-counter gel is approved for treating localized osteoarthritis pain in certain joints.
Reduced Systemic Risk: The topical gel delivers medication directly to the site of pain, resulting in less systemic absorption and a lower risk of serious side effects compared to oral NSAIDs.
Serious Warnings: All NSAIDs, including Voltaren, carry a risk of serious cardiovascular events like heart attack and stroke, as well as gastrointestinal bleeding.
Oral vs. Topical: Prescription-strength oral Voltaren is used for more systemic conditions like rheumatoid arthritis, while the topical gel is best for localized joint pain.
Doctor Consultation: It is essential to speak with a healthcare provider before using Voltaren, particularly if you have pre-existing conditions, to ensure it is safe and appropriate for your needs.

Understanding Diclofenac and Its Anti-inflammatory Action

Voltaren is a brand name for the drug diclofenac, a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs are a class of medications that work by inhibiting the body's production of prostaglandins, which are hormone-like substances responsible for causing pain and inflammation. By blocking the cyclooxygenase (COX) enzymes, diclofenac effectively reduces the levels of these inflammatory agents, providing relief from swelling, stiffness, and pain.

Unlike simple topical products that just mask pain with cooling or heating sensations, Voltaren delivers a medically active ingredient directly to the source of the problem. This localized delivery is particularly effective for treating inflammatory joint conditions, allowing the medication to target the inflamed tissues surrounding the joint and reducing systemic exposure.

Specific Inflammatory Conditions Treated by Voltaren

Voltaren is available in various formulations, including oral tablets and topical gels, designed to treat different inflammatory conditions.

Osteoarthritis

Osteoarthritis is a common use for Voltaren, particularly in its over-the-counter topical gel form. It is approved for providing temporary relief from pain and stiffness in joints that are easily accessible to topical treatment, such as the hands, wrists, elbows, knees, ankles, and feet. Clinical studies have shown significant improvement in pain for patients with osteoarthritis of the knee and other joints after consistent use.

Rheumatoid Arthritis

Prescription-strength oral Voltaren (diclofenac) is used for the management of signs and symptoms associated with rheumatoid arthritis, a more systemic inflammatory condition. While the over-the-counter topical gel is also used to help ease aching joints, the oral version provides relief for more widespread inflammation.

Ankylosing Spondylitis

For conditions like ankylosing spondylitis, which causes inflammation primarily in the spine, oral diclofenac is the prescribed form of treatment to manage pain and inflammation. The topical gel is not typically recommended for use on the back or spine.

Oral vs. Topical Voltaren: A Comparison

The choice between oral and topical Voltaren depends on the type and location of the inflammatory pain. Here is a comparison of the two forms:


Feature	Topical Voltaren (Gel)	Oral Voltaren (Tablets)
Absorption	Localized absorption through the skin to the site of pain.	Systemic absorption into the bloodstream, affecting the entire body.
Primary Use	Osteoarthritis of certain joints.	More systemic inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
Systemic Side Effects	Lower risk due to minimal systemic absorption.	Higher risk of gastrointestinal and cardiovascular side effects.
Application Site Side Effects	Potential for localized skin irritation, itching, or redness.	Not applicable.
Administration	Applied directly to the skin over the affected joint.	Taken by mouth, often with food to prevent stomach upset.

How to Use Voltaren Topical Gel for Inflammation

If using the over-the-counter topical gel, proper application is crucial for effectiveness and safety. Always read the enclosed patient information and follow instructions from a healthcare professional.

Measure Accurately: Follow instructions for measuring the correct amount of gel for the affected joint area.
Apply to Clean, Dry Skin: Gently massage the gel into the entire affected joint area.
Frequency: Apply the gel as directed for consistent relief.
Post-Application Care: Follow instructions regarding showering, bathing, and dressing after application.
Wash Hands: Wash your hands thoroughly after applying the gel, unless your hands are the area being treated.

Safety, Side Effects, and Important Warnings

While topical Voltaren has a lower risk profile for systemic side effects compared to oral NSAIDs, both forms can have serious risks, and it is vital to consult a healthcare provider before use.

Gastrointestinal (GI) Bleeding: NSAIDs, including Voltaren, carry a risk of serious GI bleeding, ulceration, or perforation. This risk is higher for those over 60, with a history of GI problems, or those taking blood thinners.
Cardiovascular Risks: Diclofenac can increase the risk of heart attack, heart failure, and stroke, especially with long-term use or higher amounts. It should not be used just before or after heart bypass surgery.
Skin Reactions: Severe skin reactions, though rare, can occur. Discontinue use and seek medical help if a rash develops.
Kidney and Liver Issues: Both forms can potentially cause damage to the liver and kidneys.
Drug Interactions: Voltaren interacts with other medications, including antidepressants, blood thinners, and diuretics. It is crucial to inform your doctor about all medications you are taking.

Conclusion

Voltaren, containing diclofenac, is a powerful and clinically proven medication for treating inflammation and pain, particularly from arthritis. The topical gel offers a valuable alternative to oral NSAIDs, providing targeted relief with a lower risk of systemic side effects. For more widespread conditions, prescription oral Voltaren may be appropriate. However, due to the potential for serious risks, all forms of Voltaren must be used with caution and under the guidance of a healthcare professional. Always consult your doctor to determine if Voltaren is the right treatment for your specific inflammatory condition, especially if you have pre-existing health issues or are taking other medications. For more detailed clinical information on the efficacy of topical diclofenac in osteoarthritis, refer to relevant research on sites like ScienceDirect.

Frequently Asked Questions

Voltaren, which contains diclofenac, works by inhibiting the body's production of prostaglandins. These substances are responsible for triggering pain and swelling, so by blocking their synthesis, Voltaren effectively reduces inflammation.

The over-the-counter topical gel is not approved for general muscle pain, strains, sprains, or sports injuries, as it is specifically formulated for osteoarthritis joint pain. The topical form has not been studied for use on all areas of the body, such as the hips or back.

Yes. The over-the-counter Voltaren Arthritis Pain Gel contains a specific concentration of diclofenac and is used for localized osteoarthritis joint pain. Prescription Voltaren is available in different concentrations and oral forms for more systemic inflammatory conditions.

Voltaren gel is not for immediate relief. While some may feel effects sooner, it may take up to seven days of consistent, continuous use, as directed by a healthcare professional, to experience significant pain relief.

Common side effects for the topical gel include localized skin reactions such as redness, dryness, itching, or rash at the application site. Serious, though less common, systemic side effects can also occur.

Individuals with a history of allergic reactions to NSAIDs (like aspirin or ibuprofen), those who have recently had heart bypass surgery, or those with significant heart or gastrointestinal problems should not use Voltaren. It is also advised to avoid use during the last trimester of pregnancy.

Using Voltaren, especially the oral form, with other NSAIDs (including aspirin and ibuprofen) can increase the risk of serious side effects like gastrointestinal bleeding. Always consult a doctor before combining Voltaren with other medications or supplements.