Skip to content

What is Xemacort Cream?: A Guide to Its Uses and Pharmacology

3 min read

In a recent study, 32.6% of participants using topical corticosteroids cited eczema as the primary reason for use. For inflamed and infected eczema, a combination cream may be prescribed. So, what is Xemacort cream? It's a dual-action prescription medication for this purpose.

Quick Summary

Xemacort is a topical prescription cream that combines a potent corticosteroid (betamethasone) and an antibiotic (fusidic acid). It is used to treat inflammatory skin conditions like eczema that are also bacterially infected.

Key Points

  • Dual-Action Formula: Xemacort combines an antibiotic (fusidic acid) and a potent corticosteroid (betamethasone).

  • Primary Use: It's prescribed for inflammatory skin conditions like eczema and dermatitis that are also bacterially infected.

  • Mechanism of Action: The fusidic acid kills bacteria, while the betamethasone reduces swelling, itching, and redness.

  • Prescription Only: Xemacort is a potent medication and requires a doctor's prescription for use.

  • Method of Use: Apply a thin layer to the affected area as directed by a healthcare professional.

  • Important Precautions: Avoid contact with eyes and do not use on viral/fungal infections, acne, or rosacea.

  • Potential Side Effects: Long-term use can lead to skin thinning, stretch marks, and systemic side effects.

In This Article

Understanding Xemacort Cream

Xemacort is a prescription medication indicated for the treatment of inflammatory skin conditions, such as eczema and dermatitis, where a bacterial infection is also present. It is not intended for skin conditions caused solely by fungal or viral infections, like athlete's foot or cold sores. The treatment course with Xemacort should typically not go beyond two weeks to minimize the risk of side effects. This medication is only available with a doctor's prescription.

The Dual-Action Pharmacology of Xemacort

Xemacort's effectiveness comes from its two active ingredients that work simultaneously:

  1. Betamethasone (as valerate): This is a potent corticosteroid, which is a synthetic version of a hormone naturally produced by the body. Its primary role is anti-inflammatory. Betamethasone works by activating natural substances in the skin to reduce swelling, redness, and itching associated with conditions like eczema and psoriasis. It is stronger than milder steroids like hydrocortisone and is often prescribed when other treatments have not been effective.

  2. Fusidic Acid: This is an antibiotic that works by stopping the growth of germs (bacteria) that cause skin infections. It is particularly effective against staphylococcal bacteria, which can cause conditions like infected dermatitis and impetigo. By eliminating the bacteria, fusidic acid helps to clear the infection, allowing the inflamed skin to heal.

How to Use Xemacort Cream

Xemacort cream should always be used exactly as prescribed by your doctor. It is for external (cutaneous) use only.

  • Application: A small, thin film of the cream should be applied to the affected area as directed by a healthcare professional.
  • Hygiene: Always wash your hands before and after applying the cream, unless you are treating your hands.
  • Sensitive Areas: Avoid getting the cream in your eyes, mouth, or on sensitive areas like genitals, armpits, or open wounds unless specifically directed by your doctor. Accidental contact with eyes can lead to increased pressure and potentially glaucoma.
  • Dressings: Do not cover the treated area with bandages or dressings unless advised by your healthcare provider, as this can increase the absorption of the steroid into the body and raise the risk of side effects.

Potential Side Effects and Precautions

Like all medications, Xemacort can cause side effects. Common, localized side effects include a mild burning or stinging sensation, itching, or dryness at the application site.

Long-term or excessive use of potent topical steroids like betamethasone can lead to more serious side effects:

  • Skin Changes: Thinning of the skin (atrophy), stretch marks, bruising easily, and changes in skin color.
  • Systemic Effects: Though rare with topical use, the steroid can be absorbed into the bloodstream, potentially leading to Cushing's syndrome or adrenal gland problems. Symptoms can include unusual tiredness, weight changes, and high blood sugar.
  • Vision Problems: Using the cream near the eyes can increase the risk of cataracts or glaucoma. Report any blurred vision or other vision changes to your doctor immediately.
  • Topical Steroid Withdrawal: After prolonged use, stopping the cream can lead to a rebound flare, with intense redness and burning that may spread beyond the original treatment area.

It is contraindicated for use in infants under one year of age and for conditions like acne, rosacea, or perioral dermatitis (a rash around the mouth).

Comparison of Topical Skin Creams

Cream Type Active Ingredient(s) Primary Use Mechanism Example Brand(s)
Combination (Steroid + Antibiotic) Betamethasone, Fusidic Acid Inflamed, infected eczema/dermatitis Reduces inflammation and kills bacteria Xemacort, Fucibet
Potent Steroid Only Betamethasone Severe eczema, psoriasis, dermatitis (non-infected) Reduces inflammation, redness, and itching Betnovate, Diprosone
Combination (Steroid + Antifungal) Betamethasone, Clotrimazole Fungal infections with inflammation (e.g., athlete's foot) Reduces inflammation and kills fungi Lotrisone
Antibiotic Only Fusidic Acid Bacterial skin infections (e.g., impetigo) Kills bacteria causing the infection Fucidin

Conclusion

Xemacort cream is a highly effective, prescription-only medication that treats eczematous dermatoses that have become bacterially infected. Its combination of a potent steroid (betamethasone) and a powerful antibiotic (fusidic acid) allows it to simultaneously manage inflammation and fight infection. However, due to the potency of its steroid component, it must be used with care, strictly following a doctor's instructions and for limited durations to avoid significant side effects. Always consult a healthcare professional for diagnosis and treatment of any skin condition.


Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare professional for diagnosis and treatment.

Authoritative Link: About betamethasone for skin - NHS

Frequently Asked Questions

Xemacort cream contains two active ingredients: fusidic acid, an antibiotic, and betamethasone, a potent corticosteroid.

Yes, Xemacort and other betamethasone skin treatments are available only by prescription from a doctor.

You should only use Xemacort on your face if your doctor specifically tells you to, as the skin is more delicate and susceptible to side effects like thinning.

Your skin should start to improve after a few days of using the cream. If you see no improvement after 7 days, you should stop using it and consult your doctor.

It is used to treat conditions where the skin is inflamed (like eczema or dermatitis) and also infected by bacteria. It is not for purely viral or fungal infections.

Uncommon but possible side effects include skin irritation, a burning or stinging feeling, itching, and redness at the application site. More serious side effects can occur with long-term use.

No, Xemacort is contraindicated for treating acne vulgaris and rosacea. Using it for these conditions can make them worse.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. 8
  9. 9
  10. 10

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.