Identification of the 855 Capsule
The capsule with the imprint "855" is a combination medication containing two active ingredients: Triamterene (37.5 mg) and Hydrochlorothiazide (25 mg). Visually, it is identifiable by its distinctive opaque yellow cap and opaque white body. This specific formulation is distributed by manufacturers like Zydus Pharmaceuticals (USA) Inc.. In cases where a person encounters a pill of unknown origin, consulting a qualified medical professional or using a verified online pill identifier is crucial for safety.
How Triamterene and Hydrochlorothiazide Work
This medication is classified as a potassium-sparing diuretic with a thiazide diuretic. The two components work together to regulate fluid balance and blood pressure through distinct mechanisms.
Hydrochlorothiazide
Hydrochlorothiazide is a thiazide diuretic, often referred to as a "water pill". It works by causing the kidneys to excrete more sodium and water into the urine. This action reduces the amount of fluid circulating in the body, which, in turn, helps lower blood pressure. While effective, a common side effect of thiazide diuretics is the depletion of potassium levels in the body.
Triamterene
Triamterene is a potassium-sparing diuretic. Its role is to help the body retain potassium that would otherwise be lost due to the effects of hydrochlorothiazide. By counteracting this potassium loss, triamterene helps maintain a healthy electrolyte balance. The combination of these two drugs offers the benefit of reduced blood pressure and edema with a minimized risk of hypokalemia (low potassium).
Uses and Indications
The 855 capsule is prescribed to treat two primary conditions:
- Hypertension (High Blood Pressure): Uncontrolled high blood pressure can lead to serious health issues like heart attack, stroke, and kidney failure. This medication helps manage blood pressure, reducing the workload on the heart and blood vessels.
- Edema (Fluid Retention): Edema is the accumulation of excess fluid in body tissues, often causing swelling in the legs, ankles, and feet. Triamterene and hydrochlorothiazide can alleviate edema associated with various conditions, including heart failure and liver disease.
This medication is not typically used for initial therapy unless a patient is already experiencing low potassium or is at high risk for developing it with hydrochlorothiazide alone.
Important Precautions and Potential Side Effects
Before taking this medication, patients should inform their doctor of any history of kidney disease, high blood potassium levels, or allergies to sulfa drugs. The following is a list of potential side effects and interactions to be aware of:
- Electrolyte Imbalance: While triamterene helps prevent potassium loss, an imbalance can still occur, requiring regular monitoring of blood electrolytes.
- Kidney Stones: Triamterene has been associated with the formation of kidney stones and should be used with caution in patients with a history of this condition.
- Hypotension and Dizziness: The blood pressure-lowering effect can cause dizziness, especially when standing up quickly. Patients should be cautious to avoid falls.
- Increased Sun Sensitivity: Hydrochlorothiazide can increase the skin's sensitivity to sunlight, making protective measures like sunscreen and proper clothing important.
- Drug Interactions: The medication can interact with NSAIDs (like ibuprofen), lithium, and other potassium-sparing agents, potentially causing adverse effects.
Comparison of Diuretic Components
| Feature | Triamterene | Hydrochlorothiazide |
|---|---|---|
| Drug Class | Potassium-sparing diuretic | Thiazide diuretic |
| Primary Function | Blocks sodium reabsorption in the distal renal tubule, retaining potassium | Increases excretion of sodium and chloride, and thus water, from the body |
| Main Benefit | Preserves potassium levels, mitigating hypokalemia | Reduces overall fluid volume and blood pressure |
| Associated Risk | Potential for hyperkalemia (high potassium) | Potential for hypokalemia (low potassium) |
| Role in Combination | Counteracts potassium loss caused by hydrochlorothiazide | Provides the primary diuretic and antihypertensive effect |
Conclusion
In conclusion, the yellow and white capsule with the imprint "855" is a combination of Triamterene and Hydrochlorothiazide, prescribed for high blood pressure and fluid retention. Its dual-diuretic action effectively manages these conditions while minimizing the risk of hypokalemia, a common side effect of many diuretic therapies. This is a prescription-only medication that should only be taken under the supervision of a healthcare provider. Adhering to medical advice and understanding the medication's function and potential side effects are essential for safe and effective treatment.
For more detailed information on Triamterene and Hydrochlorothiazide, refer to resources like MedlinePlus.
Proper Handling and Storage
To ensure the medication's effectiveness and safety, it should be stored in the container it came in, tightly closed, and away from excessive heat and moisture. Storing the capsules at controlled room temperature, typically 20° to 25°C (68° to 77°F), is recommended. Patients should never store medication in the bathroom where heat and moisture can degrade the product. If there are any questions about handling or a dose is missed, a pharmacist can provide guidance.
Important Medical Advice Disclaimer
This article is for informational purposes only and does not constitute medical advice. A healthcare provider should always be consulted for any questions or concerns about this or any other medication. Do not stop or change a medication dosage without speaking to a doctor first.
MedlinePlus Drug Information on Triamterene and Hydrochlorothiazide
Other Considerations
While Triamterene and Hydrochlorothiazide are effective, a doctor may need to adjust the dosage based on factors like age, weight, and kidney function. Regular lab tests to check serum electrolytes, kidney function (BUN and creatinine), and blood pressure monitoring are often necessary to ensure the medication is working properly and not causing adverse effects.
