Skip to content

What medication is safe during pregnancy for eczema?

5 min read

Over 50% of women with pre-existing atopic dermatitis experience a flare-up of eczema during pregnancy. Understanding what medication is safe during pregnancy for eczema is crucial for managing symptoms effectively while protecting the health of both mother and baby. Proper treatment, under the guidance of a healthcare provider, can significantly improve quality of life during this time.

Quick Summary

Managing eczema during pregnancy involves a tiered approach, starting with emollients and mild topical steroids. Specialist-supervised treatments like phototherapy and certain systemic drugs may be used for severe cases. Several medications are contraindicated during pregnancy due to potential risks, and lifestyle adjustments are essential for relief.

Key Points

  • Emollients are Safest: Moisturizers and emollients are the safest and most important first-line treatment for eczema during pregnancy and should be used multiple times a day.

  • Mild Topical Steroids are Generally Safe: Mild-to-moderate topical corticosteroids like hydrocortisone are considered safe for managing eczema flares when used sparingly and for short periods.

  • Phototherapy is a Safe Option: Narrowband UVB phototherapy is a safe and effective treatment for moderate-to-severe eczema during pregnancy and should be considered if topical treatments are insufficient.

  • Severe Cases May Need Systemic Treatment: For severe, uncontrolled eczema, specialists may consider systemic treatments like cyclosporine, weighing the benefits against potential risks for both mother and baby.

  • Certain Medications Must be Avoided: Systemic medications like methotrexate and newer JAK inhibitors are contraindicated during pregnancy due to potential fetal harm.

  • Lifestyle Changes Offer Support: Alongside medication, managing stress, avoiding triggers, and maintaining a good skincare routine with lukewarm baths are crucial for managing eczema symptoms.

In This Article

Navigating Eczema Care Safely During Pregnancy

Pregnancy brings about significant hormonal shifts and changes to the immune system, which can cause new-onset eczema or exacerbate existing atopic dermatitis. For expectant mothers, the priority is to find effective relief for symptoms like itching, inflammation, and dryness while ensuring the safety of the developing fetus. Fortunately, a range of safe and effective treatment options are available, from foundational skincare to medical interventions, when guided by a dermatologist and obstetrician.

Cornerstone Treatment: Emollients and Moisturizers

The most fundamental and safest approach for managing eczema during pregnancy is consistent, high-quality skincare using emollients and moisturizers. These products are the first line of defense, helping to repair the skin's barrier and lock in moisture.

  • Fragrance-Free and Hypoallergenic: Opt for products that are fragrance-free and formulated for sensitive or atopic skin to minimize irritation. Brands like CeraVe, Eucerin, and Vanicream offer excellent, widely available options.
  • Application is Key: Applying moisturizer multiple times a day, especially within three minutes after a lukewarm bath or shower, is vital to trap moisture effectively.
  • Proper Bathing Habits: Stick to short, lukewarm showers (under 10 minutes) and use soap-free cleansers or oils to avoid further drying out the skin.

Safe and Common Topical Medications

For flare-ups that are not managed by moisturizers alone, topical medications are the next step. Most are localized treatments with minimal systemic absorption, making them a relatively safe option when used correctly.

Topical Corticosteroids

Mild to moderate topical corticosteroids, such as 1% hydrocortisone cream (available over-the-counter), are generally considered safe for use during pregnancy. Stronger prescription-strength corticosteroids (e.g., mometasone) are also used but require more careful consideration due to a potential, though small, association with low birth weight when used in large quantities over a long period.

Important Precautions:

  • Always use the lowest potency that provides relief.
  • Limit the quantity applied and the duration of use, especially with potent steroids.
  • Avoid long-term daily use on high-absorption areas like the face, skin folds, and genitals.

Topical Calcineurin Inhibitors

Topical calcineurin inhibitors (TCIs), such as tacrolimus, are a non-steroidal option for eczema. While some studies suggest minimal systemic absorption and no increased risk of major birth defects, manufacturers are typically cautious with recommendations during pregnancy. Use should be discussed with a specialist and may be considered for severe cases, particularly if alternatives are ineffective or contraindicated.

Managing Severe Eczema Under Specialist Guidance

For severe, widespread, or unresponsive eczema, more advanced treatments may be necessary. These are typically managed by a dermatologist in close consultation with an obstetrician.

Phototherapy (Light Therapy)

Narrowband UVB (UVB) phototherapy is a safe and effective treatment option for eczema during pregnancy, especially when topical treatments fail. It works by calming the overactive immune cells in the skin that cause inflammation.

  • Considerations: Phototherapy may increase the risk of melasma (hyperpigmentation) and can lower folic acid levels, so supplementation may be recommended.

Systemic Medications

Systemic treatments affect the entire body and are reserved for severe, treatment-resistant cases. The decision to use these involves a careful risk-benefit analysis.

  • Cyclosporine: This calcineurin inhibitor is considered a first-line systemic treatment during pregnancy, with data suggesting comparable rates of miscarriage and birth defects to the general population. It is used under careful monitoring for maternal side effects like hypertension.
  • Oral Steroids: Short courses of oral corticosteroids like prednisolone may be used to manage severe, acute flares but should not be used for long-term control.
  • Biologics (Dupilumab): This treatment targets inflammatory signals and can be considered for severe cases. While animal studies show no harmful reproductive effects and initial human case reports are promising, experience is more limited than for cyclosporine. It is often continued if a patient was well-controlled on it before conception.

Medications and Treatments to Avoid

Certain eczema treatments are considered unsafe and should be avoided during pregnancy due to teratogenicity or limited safety data.

  • Methotrexate: A systemic immunosuppressant contraindicated during pregnancy.
  • JAK and TYK2 inhibitors: These newer treatments lack sufficient safety data for use during pregnancy and are not recommended.
  • PUVA phototherapy: This form of phototherapy should be avoided.
  • Topical Calcineurin Inhibitors: While data for topical tacrolimus is more reassuring, many providers will advise against use during pregnancy due to manufacturer recommendations and limited data.

Comparison of Common Eczema Treatments in Pregnancy

Treatment Safety Profile During Pregnancy Efficacy Application & Considerations
Emollients & Moisturizers Excellent, first-line and safest option High for mild eczema, cornerstone for all severity levels Use multiple times daily, especially after bathing. Choose fragrance-free formulas.
Mild Topical Corticosteroids High for mild to moderate potency Effective for managing localized flares Apply sparingly to affected areas for short periods. Use lowest effective strength.
Narrowband UVB Phototherapy Considered safe Effective for moderate to severe eczema In-office treatment. May require folic acid supplementation due to depletion.
Cyclosporine Relatively safe, use with caution Highly effective for severe cases Systemic medication. Requires specialist supervision and monitoring for side effects.

Lifestyle and Skincare Tips for Eczema Relief

Beyond medication, several lifestyle adjustments can help manage eczema symptoms effectively:

  • Identify and Avoid Triggers: Common culprits include certain fabrics (e.g., synthetics), fragrances, harsh soaps, and stress. Switching to natural fibers like cotton and using gentle, hypoallergenic products can help.
  • Manage Stress: Stress is a known trigger for eczema flares. Techniques like meditation, yoga, and prenatal massage can help maintain skin health.
  • Stay Hydrated: Drinking plenty of water is essential for overall health and helps maintain skin's moisture.
  • Dietary Adjustments: Some find certain foods increase inflammation. A whole foods-focused diet and possibly temporary elimination of common triggers like dairy or gluten may help, but should be discussed with a doctor.
  • Coconut Oil: While not a medical treatment, virgin coconut oil has emollient and anti-inflammatory properties that can be soothing for some.

Conclusion: Personalized Care is Best

Deciding on the right eczema treatment during pregnancy is a process that requires a personalized approach. While emollients and mild topical corticosteroids are generally safe and effective for many, those with more severe symptoms have options ranging from phototherapy to systemic medications under a specialist's care. It is crucial to have an open and honest conversation with both your dermatologist and obstetrician to weigh the benefits and risks of any treatment and develop a safe management plan tailored to your specific needs. Never self-medicate or start a new treatment without professional guidance during pregnancy. For more in-depth information and patient resources, the American Academy of Dermatology provides comprehensive guidelines on managing skin conditions during pregnancy.

Frequently Asked Questions

Yes, mild to moderate topical corticosteroid creams, like 1% hydrocortisone, are generally considered safe to use for eczema during pregnancy. However, potent or very potent steroids should be used sparingly and for limited durations under a doctor's supervision.

Many over-the-counter eczema creams are safe. Fragrance-free, hypoallergenic moisturizers and barrier creams are highly recommended. For creams containing hydrocortisone, stick to mild strengths (like 1%) and consult your doctor.

Avoid systemic immunosuppressants like methotrexate and JAK inhibitors. Also, certain forms of phototherapy (PUVA) are not recommended. Always discuss any existing medications with your doctor.

Yes, narrowband UVB phototherapy is considered safe for treating moderate to severe eczema during pregnancy. It is a non-medicated approach that can reduce inflammation effectively.

Natural management includes regular use of fragrance-free emollients, short lukewarm baths, trigger avoidance, and stress management. Some people find relief with natural emollients like coconut oil, but always check with a healthcare provider.

While topical steroids have low systemic absorption, high-potency formulations used in large amounts over long periods may be associated with a slightly increased risk of low birth weight. Healthcare providers advise using the lowest effective potency for the shortest duration.

Topical calcineurin inhibitors like tacrolimus are not currently recommended by manufacturers during pregnancy due to limited safety data. However, some evidence suggests minimal absorption. Use should only be considered in severe cases under specialist supervision, as per the American Academy of Dermatology.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. 8

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.