The Primary Medication for Height: Human Growth Hormone (HGH)
The main prescription medication used to help children grow taller is a man-made version of human growth hormone (HGH), known generically as somatropin. This drug is similar to the growth hormone naturally produced by the pituitary gland and is crucial for stimulating bone growth in childhood.
Somatropin is administered as a daily or weekly injection. Brand names include Norditropin, Genotropin, and Humatrope, with some available in a once-weekly form. Treatment is most effective when started early and continues until the growth plates in the bones close, usually around age 14 for girls and 16 for boys.
How HGH Promotes Growth
HGH facilitates growth through a multi-step process:
- Stimulation: HGH travels in the bloodstream.
- IGF-1 Production: It prompts the liver and other tissues to make Insulin-like Growth Factor-I (IGF-1).
- Growth Plate Action: Both HGH and IGF-1 act on growth plates, stimulating cartilage cells to divide.
- Bone Elongation: New cartilage forms, and old cartilage becomes bone, causing bones to lengthen.
FDA-Approved Conditions for HGH Treatment
Before prescribing HGH, a pediatric endocrinologist must identify an underlying cause of short stature. The FDA has approved somatropin for several conditions in children:
- Growth Hormone Deficiency (GHD): The pituitary gland doesn't produce enough growth hormone.
- Idiopathic Short Stature (ISS): Significant shortness without a known medical reason. HGH was approved for ISS in 2003 and can increase adult height by 1.5 to 3 inches.
- Turner Syndrome: A genetic condition affecting female development and height.
- Noonan Syndrome: A genetic disorder impacting development in various body parts.
- Prader-Willi Syndrome (PWS): A complex genetic condition affecting growth and metabolism.
- Chronic Kidney Disease (CKD): Short growth can be a complication.
- Small for Gestational Age (SGA): For children born small who don't catch up in growth.
- SHOX Gene Deficiency: Involves a gene important for bone development.
Other Medications Affecting Height
Beyond HGH, other medications may be used for specific conditions:
- Vosoritide (Voxzogo): Approved for children with achondroplasia, a form of dwarfism. It is a daily injection that helps regulate bone growth in this condition and has shown to increase growth velocity.
- Aromatase Inhibitors: Sometimes used off-label in boys to delay growth plate fusion by blocking estrogen production. While potentially allowing for longer growth, their impact on final height and potential side effects on vertebrae are still being studied.
Comparison of Height-Increasing Medications
Medication | Primary Mechanism | Target Condition(s) | Administration |
---|---|---|---|
Somatropin (HGH) | Replaces or supplements natural growth hormone, stimulating IGF-1 production. | GHD, ISS, Turner Syndrome, Noonan Syndrome, PWS, CKD, SGA, SHOX Deficiency. | Daily or weekly subcutaneous injection. |
Vosoritide (Voxzogo) | Acts as a C-type natriuretic peptide (CNP) analog to regulate bone growth. | Achondroplasia. | Daily subcutaneous injection. |
Aromatase Inhibitors | Block the conversion of androgens to estrogens, delaying growth plate fusion (in boys). | Off-label for Idiopathic Short Stature, Constitutional Delay of Growth. | Oral pill. |
Safety, Side Effects, and Cost
HGH therapy is generally safe, with infrequent side effects like headaches, joint pain, and injection site reactions. Children receiving HGH are monitored regularly by a pediatric endocrinologist.
The cost of HGH therapy is high, often ranging from $1,000 to over $5,000 monthly. Insurance coverage is typically necessary and requires a diagnosis of an FDA-approved condition.
Conclusion
FDA-approved medications for increasing height in children are prescription drugs for specific medical conditions, not cosmetic enhancement. Somatropin (HGH) is the most common treatment for a range of growth disorders, while Vosoritide is used for achondroplasia. A pediatric endocrinologist must diagnose the underlying cause and manage treatment. Parents concerned about their child's growth should consult a healthcare professional.
Authoritative Link: Somatropin Information from the FDA