Understanding Wynzora and Its Purpose
Wynzora is a prescription medication indicated for the topical treatment of plaque psoriasis in adults aged 18 and older. It combines two active ingredients: calcipotriene, a synthetic vitamin D analog, and betamethasone dipropionate, a potent corticosteroid. While the exact mechanism is unknown, calcipotriene helps slow the rapid growth of skin cells, and betamethasone reduces inflammation, itching, and redness associated with psoriasis plaques.
This medication is formulated using PAD™ Technology, which enables the oil and water-based ingredients to be mixed with fewer emulsifiers, enhancing the stability and penetration of the active components.
Step-by-Step Guide: How to Use Wynzora?
Correct application is key to maximizing the effectiveness of Wynzora and minimizing potential side effects. Always follow the specific instructions provided by your healthcare provider.
- Preparation: Before applying, ensure your hands are clean and dry. For first-time use, remove the cap and puncture the aluminum seal using the point on the top of the cap.
- Application: Apply a thin layer of Wynzora cream to the affected areas as directed by your healthcare provider, typically once daily.
- Rub In Gently: Gently rub the cream into the skin until the plaques are fully saturated and the cream is absorbed. If treating psoriasis on the scalp, you can part the hair to apply the cream directly to the plaques.
- Post-Application: Wash your hands thoroughly after applying the cream, unless your hands are the treatment area. To achieve the best results, follow your doctor's recommendations regarding showering or bathing after application to allow the cream to be absorbed.
- Important Restrictions:
- Do not exceed the maximum weekly amount of Wynzora recommended by your doctor.
- Avoid applying the cream to your face, groin, armpits, or areas with skin thinning (atrophy).
- Wynzora is for external use only. Do not use it in the mouth, eyes, or vagina. If accidental contact occurs with the eyes, wash the area immediately with water.
- Do not cover the treated area with a bandage or occlusive dressing unless specifically instructed by your doctor.
Treatment duration is determined by your healthcare provider, often up to 8 weeks. You should discontinue therapy once control is achieved, unless otherwise directed.
Potential Side Effects and Warnings
While many users do not experience serious side effects, it's important to be aware of them. The most common side effects include upper respiratory infection, headache, and application site irritation.
Serious Side Effects
Wynzora can cause more serious side effects due to the absorption of its active ingredients into the bloodstream:
- Hypercalcemia: Too much calcium in your blood or urine. Symptoms can include constipation, dry mouth, confusion, and muscle weakness. Your doctor may monitor your calcium levels.
- HPA Axis Suppression: The potent corticosteroid can cause your adrenal glands to stop working properly, a condition that can lead to Cushing's syndrome or high blood sugar (hyperglycemia).
- Ophthalmic Risks: Use of topical corticosteroids may increase the risk of developing cataracts and glaucoma. Report any blurred vision or other vision changes to your doctor immediately.
- Skin Reactions: Prolonged use can lead to skin thinning, stretch marks (striae), and folliculitis (small red bumps).
Precautions
- Inform your doctor about all medical conditions, especially if you have a calcium metabolism disorder, liver disease, or thinning skin at the treatment site.
- Wynzora can make your skin more sensitive to the sun. Avoid excessive sun exposure and tanning beds, and use sunscreen (SPF 30 or higher) outdoors.
- Do not use other products containing calcipotriene or a corticosteroid while using Wynzora without consulting your healthcare provider.
Wynzora vs. Other Topical Treatments
Wynzora is often compared to other combination topical treatments for psoriasis. Its unique PAD™ Technology formulation is designed for improved tolerability and convenience.
| Feature | Wynzora® Cream | Taclonex® Topical Suspension |
|---|---|---|
| Active Ingredients | Calcipotriene 0.005% & Betamethasone Dipropionate 0.064% | Calcipotriene 0.005% & Betamethasone Dipropionate 0.064% |
| Formulation | Water-based cream with PAD™ Technology | Ointment or liquid suspension |
| Application | Once daily | Once daily |
| Efficacy (Week 8) | In a Phase 3 trial, 37.4% of patients achieved "clear or almost clear" skin. | In the same trial, 22.8% of patients using the topical suspension achieved "clear or almost clear" skin. |
| Approved For | Adults 18 years and older for plaque psoriasis. | Plaque psoriasis of the scalp and body in patients 12 years and older. |
Conclusion
Wynzora cream is an effective once-daily treatment for plaque psoriasis in adults, showing significant improvement in skin clearance and itching, sometimes as early as the first week. To ensure safety and efficacy, it is critical to follow the prescribed directions on how to use Wynzora?. Adhering to the application guidelines, usage limits, and restricted areas helps manage the condition while minimizing risks. Always consult your healthcare provider to understand the benefits and risks and to ensure this treatment is right for you.
For more detailed official information, you can review the FDA-approved patient labeling.
