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Can I take magnesium and zinc picolinate together? A Guide to Safe Supplementation

4 min read

Data from the National Health and Nutrition Examination Survey (NHANES) found that 48% of Americans of all ages consume less magnesium than recommended from food and beverages. It is safe for most people to supplement, but a common question is: can I take magnesium and zinc picolinate together?

Quick Summary

Taking magnesium and zinc picolinate together is generally safe and can be beneficial. These minerals are synergistic, but high amounts of zinc can interfere with magnesium absorption.

Key Points

  • Generally Safe: Taking magnesium and zinc picolinate together is safe and beneficial for most people at recommended amounts.

  • Synergistic Benefits: The minerals work together to support sleep, bone health, immune function, and mood.

  • Intake is Key: Very high amounts of zinc can interfere with magnesium absorption; it's crucial to stick to recommended intake guidelines.

  • Bioavailability Matters: Zinc picolinate and magnesium forms like glycinate or citrate offer better absorption than other forms like oxide.

  • Consult a Professional: People with kidney disease or those on certain medications should talk to a doctor before supplementing.

In This Article

Medical Disclaimer

Information provided in this article is for general knowledge and should not be taken as medical advice. Always consult with a healthcare provider before starting any new supplement regimen.

Understanding Magnesium and Zinc

Magnesium and zinc are essential minerals, meaning the body cannot produce them and must obtain them through diet or supplementation. They are both involved in hundreds of vital biochemical reactions.

Magnesium plays a critical role in nerve and muscle function, bone health, blood pressure regulation, and energy production. It helps activate vitamin D, which is crucial for calcium absorption. Zinc is fundamental for a healthy immune system, wound healing, protein and DNA synthesis, and normal growth. It also functions as an antioxidant.

What Does 'Picolinate' Mean?

Zinc picolinate is a specific form of zinc supplement. It is created by binding zinc to picolinic acid, a natural compound that aids in mineral transport within the body. This form is known for its high bioavailability, meaning the body can absorb and utilize it more efficiently compared to other forms like zinc gluconate or zinc oxide. Choosing a bioavailable form like zinc picolinate can be especially beneficial for those looking to effectively raise their zinc levels.

Can You Take Magnesium and Zinc Picolinate Together?

The short answer is yes, for most people, taking magnesium and zinc supplements together is considered safe and can even be synergistic. Magnesium helps the body regulate its zinc levels, and zinc can help the body absorb magnesium more effectively. Many combination supplements, including the popular ZMA (Zinc, Magnesium Aspartate, and Vitamin B6) formulas, are based on this synergistic relationship.

However, the balance of intake is crucial. Extremely high amounts of zinc can interfere with magnesium absorption. This competition for absorption occurs because minerals can use similar pathways in the intestines. Specifically, research indicates that a very high daily intake of zinc can impair the body's ability to absorb magnesium. For this reason, it's important to be mindful of intake and not consume excessive amounts of zinc.

Shared Benefits of Joint Supplementation

Taking magnesium and zinc together can offer a range of health benefits due to their complementary roles in the body:

  • Improved Sleep Quality: Both minerals contribute to better sleep. Magnesium helps calm the nervous system, while some studies have shown that a combination of zinc, magnesium, and melatonin helped older adults with insomnia fall asleep faster and improved sleep quality.
  • Enhanced Bone Health: Magnesium is essential for activating Vitamin D, which aids calcium absorption, and zinc supports bone-building cells. Deficiencies in both have been linked to an increased risk of osteoporosis.
  • Boosted Immune Function: Zinc plays a primary role in immune cell development and function, while magnesium has anti-inflammatory properties and helps synthesize other key immune-supporting nutrients.
  • Mood and Mental Health: Deficiencies in both minerals have been linked to depression and anxiety. Some studies suggest that supplementing with magnesium may reduce feelings of anxiety, and adequate zinc intake is associated with a lower likelihood of depression.
  • Blood Sugar Control: For individuals with type 2 diabetes, taking zinc and magnesium together has been shown to improve insulin levels, blood sugar, and cholesterol.

Recommended Intake and Best Practices

Adhering to the Recommended Dietary Allowance (RDA) is key to avoiding negative interactions. The general RDA for adults for these minerals is available from health authorities.

When taking supplements, it's often advised to be mindful of intake levels to avoid potential gastrointestinal side effects.

To maximize benefits and minimize interactions:

  1. Time Your Doses: Some experts suggest taking magnesium in the evening to promote relaxation and sleep, and taking zinc with a meal to reduce the chance of stomach upset. If you are concerned about absorption competition, you can take them at different times of the day.
  2. Choose High-Quality Forms: In addition to zinc picolinate, look for highly bioavailable forms of magnesium like magnesium glycinate, citrate, or malate. Magnesium oxide is less bioavailable and more likely to have a laxative effect.
  3. Take with Food: Taking both minerals with food can help prevent potential stomach upset.

Mineral Comparison Table

Feature Magnesium Zinc
Primary Functions Muscle relaxation, nerve function, bone health, energy production Immune support, wound healing, protein synthesis, growth
Good Food Sources Leafy greens, nuts, seeds, dark chocolate, avocados Oysters, red meat, poultry, beans, nuts
Best Supplement Forms Glycinate, Citrate, Malate Picolinate, Glycinate

Potential Side Effects and Precautions

While generally safe in appropriate amounts, excessive intake can lead to side effects.

  • High Magnesium: Diarrhea, nausea, and stomach cramps are common. Very high intake can lead to more serious issues like low blood pressure and muscle weakness.
  • High Zinc: Nausea, vomiting, loss of appetite, and stomach cramps. Long-term high intake can lead to copper deficiency and reduced immune function.

Individuals with certain health conditions, such as kidney disease, or those taking specific medications like antibiotics or diuretics, should consult a healthcare provider before starting magnesium and zinc supplements.

Authoritative Link: National Institutes of Health - Magnesium Fact Sheet for Health Professionals

Conclusion

You can safely take magnesium and zinc picolinate together, and doing so can provide synergistic health benefits, particularly for sleep, bone health, and immune function. The key is to maintain a proper balance and avoid excessively high amounts of zinc, which could hinder magnesium absorption. Always choose bioavailable forms of each supplement, adhere to recommended daily allowances, and consider timing your doses for optimal effect. Before beginning any new supplement regimen, it is always best to consult with a healthcare professional to determine the right approach for your individual needs.

Frequently Asked Questions

Yes, you can take them at the same time. Many supplements combine them. However, if taking high amounts, you might consider separating them to maximize absorption.

Many people prefer taking magnesium in the evening to promote relaxation and sleep, while zinc is often recommended with a meal to prevent stomach upset. You can take them together with your evening meal.

Yes, studies suggest that high zinc intake can interfere with magnesium absorption.

Zinc picolinate is a form of zinc chelated (bound) to picolinic acid. This form is known for having high bioavailability, meaning your body can absorb and use it very effectively.

When taken at recommended amounts, side effects are uncommon. However, high amounts can cause gastrointestinal issues like nausea, diarrhea, and stomach cramps. Excessive zinc can also lead to copper deficiency over time.

Combined, they can help improve sleep quality, support bone health, boost the immune system, regulate blood sugar, and enhance mood.

Highly bioavailable forms of magnesium like magnesium glycinate, magnesium citrate, or magnesium malate are excellent choices to pair with zinc picolinate, as they are well-absorbed and gentle on the stomach.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.