For individuals managing anxiety or depression with an antidepressant like Lexapro (escitalopram), an upcoming trip can present a challenge. Motion sickness medications, often sold over-the-counter, can interact with Lexapro in potentially problematic ways. The primary concern with combining these medications involves heightened side effects, particularly increased drowsiness and impaired cognitive function. Before self-treating, it is vital to understand these risks and discuss a safe approach with a healthcare provider.
Common Motion Sickness Medications and Their Interactions with Lexapro
Motion sickness medications typically fall into two main categories: antihistamines and anticholinergics. Each class has distinct effects that can be intensified when combined with Lexapro, a type of Selective Serotonin Reuptake Inhibitor (SSRI).
Antihistamines: Dramamine and Bonine
Many popular over-the-counter motion sickness pills are antihistamines, such as Dramamine (dimenhydrinate) and Bonine (meclizine). These drugs work by blocking histamine receptors in the brain, which helps to prevent nausea and dizziness. However, their primary side effect is sedation. Lexapro can cause its own set of side effects, and when taken with antihistamines, the combination can lead to a significant increase in sedation and cognitive impairment.
Combining Lexapro and Dramamine, for instance, can cause amplified side effects such as:
- Dizziness and excessive drowsiness
- Confusion and disorientation
- Difficulty concentrating
- Impairment of judgment and motor coordination
These effects can make activities requiring mental alertness, like driving, extremely dangerous. The risk is particularly elevated in older adults.
The Anticholinergic: Scopolamine
Transdermal scopolamine patches, sold under the brand name Transderm Scōp, are another common treatment for motion sickness. Scopolamine is an anticholinergic drug, and its combination with Lexapro can also increase the risk of side effects like drowsiness, confusion, and dizziness. In some cases, the interaction may also increase the risk of an irregular heart rhythm, particularly in those with underlying heart conditions. This combination requires careful medical supervision.
Less Common but Serious: Serotonin Syndrome
While typically not a high risk with standard antihistamine motion sickness pills, a more serious condition called serotonin syndrome can occur when Lexapro is combined with other medications that increase serotonin levels. Some anti-nausea medications, like ondansetron (Zofran), are potent serotonergic drugs. Combining ondansetron and Lexapro can increase the risk of serotonin syndrome, which involves symptoms such as agitation, hallucinations, a rapid heart rate, and fever. It is crucial to be aware of the signs of serotonin syndrome and to inform your doctor about all medications you are taking.
Comparing Lexapro Interactions with Common Motion Sickness Pills
| Feature | Dramamine (Dimenhydrinate) | Bonine (Meclizine) | Scopolamine (Patch) |
|---|---|---|---|
| Mechanism | Antihistamine | Antihistamine | Anticholinergic |
| Primary Interaction | Increased CNS depression, drowsiness, confusion, and impaired coordination | Increased CNS depression, drowsiness, confusion, and impaired coordination | Increased CNS depression, drowsiness, confusion, and impaired coordination |
| Serotonin Syndrome Risk | Low risk with this specific drug | Low risk with this specific drug | Low risk with this specific drug |
| Cardiovascular Risk | Rare but possible risk of irregular heart rhythm | Rare but possible risk of irregular heart rhythm | Possible risk of irregular heart rhythm |
| Recommendation | Caution, avoid without doctor approval. High potential for enhanced sedation | Caution, avoid without doctor approval. High potential for enhanced sedation | Caution, avoid without doctor approval. Potential for increased side effects |
Safer Alternatives for Managing Motion Sickness
If you are on Lexapro, there are many non-pharmacological methods to manage motion sickness that do not carry the risk of drug interactions. These strategies should be your first line of defense.
Non-Pharmacological Strategies:
- Environmental adjustments: Sit in the front seat of a car or bus, or over the wing of an airplane, where motion is less pronounced. Focus on the horizon to help your brain and inner ear signals align.
- Dietary changes: Eat small, frequent meals of bland foods like crackers. Avoid heavy, greasy, or spicy foods before travel. Sipping on cold water or a carbonated beverage like ginger ale can also help settle your stomach.
- Ginger: Known for its anti-nausea properties, ginger can be consumed in many forms, including capsules, ginger chews, or ginger tea. It is generally considered a safe and effective remedy.
- Acupressure wristbands: Bands that apply pressure to a specific point on the wrist have shown some efficacy for managing nausea in some individuals.
- Distraction: Listening to music, carrying on a conversation, or other forms of distraction can help take your mind off the discomfort.
Always Consult a Healthcare Provider
Before taking any medication for motion sickness while on Lexapro, it is essential to consult a healthcare provider. Only a doctor or pharmacist can provide personalized advice based on your medical history, specific dosage, and other medications you may be taking. Never stop taking Lexapro or any prescribed medication without first speaking to your doctor.
Conclusion
Combining common motion sickness medications like Dramamine, Bonine, or scopolamine with Lexapro is not recommended due to a significant risk of increased drowsiness, dizziness, and impaired coordination. While the risk of serotonin syndrome is lower with these specific combinations compared to other drug classes, caution is still warranted. Relying on non-drug alternatives like ginger, acupressure, and strategic seating is a safer initial approach. Always consult your doctor or pharmacist to discuss your travel plans and receive guidance on the safest options for managing motion sickness while on Lexapro.
