Before considering any new supplement, including NAD+ precursors, it is essential to consult with a healthcare professional to determine if it is appropriate for your individual health needs.
Understanding NAD+ and Its Importance
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme found in every living cell. It plays a critical role in numerous biological processes, acting as a key component for cellular energy production and metabolism. NAD+ helps convert the food we eat into the energy our cells need to function and is essential for repairing damaged DNA. As individuals age, the natural levels of NAD+ in the body decline, a process that researchers have linked to many age-related health conditions. This decline has sparked significant interest in supplements that aim to boost NAD+ levels, with the hope of supporting cellular health.
Types of NAD+ Supplements: Precursors are Key
Directly supplementing with NAD+ is not effective because the molecule is not well-absorbed by the body. Instead, the market focuses on NAD+ precursors—smaller molecules that the body can easily absorb and convert into NAD+. The most common and studied precursors are:
- Nicotinamide Riboside (NR): NR is a form of vitamin B3 that is efficiently converted into NAD+ within the cells. It is one of the most well-research ed precursors and is widely available as a dietary supplement.
- Nicotinamide Mononucleotide (NMN): NMN is another direct precursor to NAD+. While popular, its regulatory status in the United States is complicated. In late 2022, the FDA determined that NMN could not be marketed as a dietary supplement because it was first investigated as a new drug. Despite this, NMN products remain available through some online retailers, although major platforms have restricted sales. The FDA is expected to provide a final determination on the matter by September 30, 2025.
Can You Buy NAD at Walgreens?
Yes, you can buy NAD+ precursor supplements at Walgreens. The selection primarily consists of products containing Nicotinamide Riboside (NR), which remains fully classified as a dietary supplement.
Walgreens' website and stores list several brands that offer NAD+ boosting supplements, including:
- Life Extension NAD+ Cell Regenerator: This product features Nicotinamide Riboside.
- Codeage Liposomal NAD+: Codeage offers several NAD+ supplements, often in liposomal form for enhanced absorption.
- Force Factor NAD+ Longevity Complex: This is another brand available through Walgreens that provides an NAD+ boosting formula.
It is important to note that inventory can vary between online and physical stores. Some products may be available for shipping or same-day delivery, while others might not be stocked in all locations. The controversial precursor, NMN, is generally not found at major retailers like Walgreens due to its regulatory status.
Scientific Research on NAD+ Benefits and Risks
The interest in NAD+ supplementation is driven by its potential to combat age-related cellular decline. Research, largely conducted on animal models and smaller human trials, suggests several potential benefits:
- May Reduce Inflammation: One of the most consistent findings across studies is that boosting NAD+ can lower inflammatory markers.
- Supports Cellular Energy and Metabolism: NAD+ is fundamental to converting food into cellular energy. Studies suggest that boosting its levels could improve metabolic health and insulin sensitivity.
- May Improve Muscle and Cognitive Function: Some human trials have shown that NAD+ supplementation may improve exercise performance and muscle strength in older adults. Preliminary research also points to potential neuroprotective effects, though more study is needed.
However, it's crucial to approach these findings with caution. Many of the most exciting results come from animal studies, and human research is still in its early stages. Experts emphasize that long-term effects in humans are not yet known. While NAD+ supplements like NR are generally considered safe with mild side effects like nausea or headache reported at high doses, there is some concern that they could fuel the growth of existing cancer cells, which have high energy demands. For this reason, individuals with active cancer are often advised to avoid NAD+ boosters.
Comparison of Retailers for NAD+ Supplements
| Feature | Walgreens | CVS | GNC | Online Specialty Stores |
|---|---|---|---|---|
| Primary Precursor | Nicotinamide Riboside (NR) | Similar NR-based products | Wide variety of NR and other formulas | NR and NMN (despite FDA status) |
| Key Brands | Life Extension, Codeage, Force Factor | Varies; may have store-brand equivalents | Codeage, Qualia, GNC-branded products | Wonderfeel, ProHealth, Renue by Science |
| Price Point | Competitive for mainstream brands (e.g., ~$25-$90) | Price data is limited but expected to be competitive. | Generally higher-end, with specialty formulas | Wide range, can be more expensive due to purity claims |
| Convenience | High (in-store, delivery, online) | High (in-store, online) | Moderate (fewer locations than pharmacies) | High (direct-to-consumer) but requires research |
Conclusion: Making an Informed Choice
You can buy NAD+ precursor supplements, specifically those containing Nicotinamide Riboside (NR), at Walgreens both online and in stores. Brands like Life Extension and Codeage are readily available, making it a convenient option for many consumers. While the science behind NAD+ is promising for supporting cellular health, the research in humans is still evolving. The precursor NMN faces an uncertain regulatory future in the U.S. and is not typically sold by major chain pharmacies. Before starting any new supplement regimen, it is always best to consult with a healthcare provider to ensure it is appropriate for your individual health needs and to discuss potential risks and benefits.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. The statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
For more in-depth information on NAD+ metabolism from a primary research source, you can review literature from the National Institutes of Health. [Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/]
