Category: Obesity

Clinical trial data extending beyond three years have shown that tirzepatide can lead to substantial and sustained reductions in body weight and improved glycemic control. These positive outcomes come with important considerations regarding the long term effects of tirzepatide, including the management of potential side effects and the need for continuous treatment to maintain benefits.

As of July 1, 2025, CVS Caremark, the pharmacy benefits manager (PBM), removed the obesity medication Zepbound from its standard formulary for many patients. This major insurance change has caused confusion, but patients can still physically fill their Zepbound prescription at a CVS retail pharmacy, provided they have a valid prescription and a way to pay for it.

Pharmaceutical patents protect new drugs for many years, which is why there is currently no FDA-approved generic substitute for Mounjaro. While a generic equivalent does not exist, several FDA-approved brand-name alternatives and other compounded options are available for managing type 2 diabetes and weight.

During clinical trials, people taking Zepbound often noticed initial weight loss around four weeks, which corresponds with the medication reaching a consistent "steady state" level in the body. The appetite suppression effects of Zepbound are designed to last for the entire once-weekly dosing cycle, providing continuous support for weight management.

In the United States, over 40% of adults have obesity [1.2.2]. For those seeking medical support, a key question arises: **What is the best pill for high BMI**? This guide provides a detailed look at FDA-approved options.

The starting dose for Wegovy is typically administered once per week for an initial period, a phase designed to help the body acclimate to the medication. This raises a common question for many patients: 'Can you stay on .25 Wegovy?' The approach to dosage is nuanced and depends on individual response, side effect tolerance, and health goals.

Retatrutide is a novel triple-agonist peptide under development for obesity and diabetes. So, **what is in retatrutide?** Its unique composition activates three key metabolic receptors, offering powerful weight loss and glucose control that surpasses earlier medications.