Zepbound's 2025 List Price and High Retail Cost
For those without insurance, the starting point for Zepbound's cost is its high list price. The manufacturer, Eli Lilly, has set the list price for a 28-day supply of Zepbound injector pens at approximately $1,086.37. However, the actual retail price can be even higher, with some pharmacies listing the drug for over $1,500 without discounts. This cost, which covers a month's worth of weekly injections, can be prohibitive for many uninsured patients, making a deeper dive into cost-saving strategies essential.
The Reason for Zepbound's High Price
Zepbound, along with other similar GLP-1 medications, carries a high price tag primarily because it is a new, brand-name drug still protected by patent. The active ingredient, tirzepatide, is exclusively manufactured and marketed by Eli Lilly. The patent is not set to expire until 2036, meaning no generic, lower-cost versions are available and will not be for over a decade.
Manufacturer Discounts Through LillyDirect
The most substantial discount for self-paying and uninsured patients comes directly from the manufacturer via the LillyDirect Self Pay Pharmacy Solutions program. Through this program, Zepbound is offered in single-dose vials at a significantly reduced cash price, bypassing traditional retail pharmacy channels.
Here are the discounted monthly prices for vials, which require manual injection with a separate syringe and needle:
- 2.5 mg starter dose: $349 per month
- 5 mg, 7.5 mg, and 10 mg doses: $499 per month for initial and subsequent fills when refilled within 45 days
It is important to note that this lower price for vials is not available through insurance. It is a specific self-pay option from the manufacturer designed for cash-paying customers. This means that while it is a major saving, it also changes the administration method from the convenient auto-injector pen to a vial and syringe.
Using Third-Party Prescription Discount Cards
For those who still prefer the convenience of the injector pens, third-party discount card services can offer some relief from the full retail price. These services, such as SingleCare and GoodRx, partner with pharmacies to offer coupons that can lower the cost. For example, SingleCare quotes the price for pens starting at around $950 per month, a notable reduction from the average retail price.
List of considerations for using discount cards:
- Varying Costs: Prices can differ between pharmacies, so it is recommended to compare prices for your specific dosage and location.
- Cannot Be Combined: These coupons cannot be used in conjunction with any insurance coverage.
- Not Manufacturer Savings Card: Do not confuse these third-party coupons with Eli Lilly's official Zepbound Savings Card, which is for patients with commercial insurance.
Comparison of Zepbound Cost-Saving Strategies for Uninsured Patients
| Cost-Saving Option | Monthly Price (Approx.) | Medication Form | Requires | Best For |
|---|---|---|---|---|
| Full Retail Price | $1,086-$1,507 | Pre-filled pens | No discounts | Patients needing immediate pens without exploring savings |
| LillyDirect Self-Pay Vials | $349-$499 | Single-dose vials | Using a syringe, buying direct | Greatest monthly savings |
| Third-Party Discount Cards | $950-$1,020 | Pre-filled pens | Coupon from provider (e.g., SingleCare) | Discounted pens at local pharmacies |
| Lilly Cares Program | $0 | Varies | Income-based eligibility | Free medication for qualifying, low-income patients |
Patient Assistance Programs and Other Avenues
In addition to the LillyDirect program, some patients may qualify for further assistance. The Lilly Cares Foundation Patient Assistance Program offers prescribed Lilly medications at no cost to eligible low-income individuals in the U.S.. Eligibility is based on income and other specific criteria, so patients should check the program's requirements. Another option, while not currently available, involves international pharmacies. As of 2025, Zepbound is not yet available in Canadian pharmacies, so purchasing it internationally is not a current option.
Conclusion: Making an Informed Decision
For uninsured individuals, the cost of Zepbound can be a substantial barrier. However, multiple strategies exist to lower out-of-pocket expenses significantly. The most impactful savings come from purchasing discounted vials directly through the LillyDirect Self Pay program, which requires patients to switch from auto-injector pens to manual syringe injections. Alternatively, using third-party discount cards can reduce the retail cost of the more convenient pens. By evaluating your financial situation, willingness to use vials, and eligibility for assistance programs, you can find the most affordable path to receiving your Zepbound prescription.
How to Explore Your Zepbound Savings
- Step 1: Consult Your Doctor. Discuss Zepbound and its cost, and confirm that the single-dose vial option is appropriate for your treatment plan. Your doctor can provide guidance on administration if you opt for vials.
- Step 2: Compare LillyDirect vs. Discount Cards. Calculate whether the deeper savings of the LillyDirect vial program ($349-$499) outweigh the convenience of the pen format, even with a third-party discount card ($950+).
- Step 3: Check Lilly Cares Eligibility. If your income is a significant barrier, visit the Lilly Cares Foundation website to determine if you qualify for their patient assistance program.
- Step 4: Shop Around. If using a third-party discount card, search for the best prices at various pharmacies using sites like GoodRx or SingleCare.
For more details on Zepbound's FDA approval, visit the official FDA website.
