The Invega shot, containing the active ingredient paliperidone palmitate, is a long-acting injectable atypical antipsychotic medication used to treat schizophrenia and schizoaffective disorder. Administered by a healthcare professional, the medication is available in different formulations, such as Invega Sustenna (monthly), Invega Trinza (quarterly), and Invega Hafyera (bi-annually). While effective in managing symptoms, it is associated with a range of potential side effects, both common and serious.
Common Side Effects
Common side effects are those that occur frequently but are generally manageable. They are typically not life-threatening but can significantly impact a patient's quality of life.
- Injection Site Reactions: Pain, swelling, or redness at the injection site are common.
- Drowsiness or Sedation: Excessive sleepiness is a frequent side effect.
- Restlessness (Akathisia): An urge to move and inability to sit still is commonly reported.
- Headache: Headaches are a common complaint.
- Upper Respiratory Tract Infections: Cold-like symptoms can occur.
- Gastrointestinal Issues: Nausea, vomiting, stomach pain, or constipation are possible.
- Dizziness: Feeling dizzy, especially when standing, can increase fall risk.
Serious Side Effects and Warnings
Some side effects are more serious and require immediate medical attention.
Movement Disorders
Antipsychotics like Invega can cause involuntary movement disorders (EPS), which can sometimes become permanent.
- Tardive Dyskinesia (TD): Involves repetitive movements, often of the face and mouth, and may not resolve after stopping medication.
- Parkinsonism: Includes tremors and stiffness.
- Acute Dystonia: Painful muscle spasms.
Metabolic Changes
Invega can affect metabolism, increasing risks for certain conditions.
- Weight Gain: Significant weight gain is common.
- High Blood Sugar and Diabetes: Can increase blood sugar.
- High Cholesterol: Abnormal blood fat levels can occur.
Hormonal Issues (Hyperprolactinemia)
Invega can increase prolactin, causing hormonal side effects in both men and women.
- In Women: Irregular periods and milk production.
- In Men: Breast enlargement and decreased sex drive.
Other Serious Risks
- Neuroleptic Malignant Syndrome (NMS): A rare but serious condition with fever, muscle stiffness, and confusion.
- Heart Problems: Can cause abnormal heart rhythms (QT prolongation).
- Orthostatic Hypotension and Falls: Sudden blood pressure drop when standing can cause dizziness.
- Increased Risk in Elderly Patients with Dementia: A boxed warning notes increased death risk in elderly patients with dementia-related psychosis; Invega is not approved for this use.
Comparison of Invega Shot Formulations
All Invega formulations contain paliperidone and have similar side effects, but frequencies can vary. The table summarizes common side effects.
| Side Effect | Invega Sustenna (monthly) | Invega Trinza (3-monthly) | Invega Hafyera (6-monthly) |
|---|---|---|---|
| Injection Site Reactions | Very Common (>5%) | Common (>5%) | Common (>5%) |
| Weight Gain | Common (11.9%) | Common (9%) | Common (>5%) |
| Akathisia (Restlessness) | Common (11.1%) | Common (5%) | Common (>5%) |
| Drowsiness/Sedation | Common (>5%) | Common (1%-10%) | Common (1%-10%) |
| Headache | Common (10.7%) | Common (9%) | Common (>5%) |
Conclusion
The Invega shot effectively treats serious mental health conditions but has side effects, from common issues like injection site pain and drowsiness to serious risks like movement disorders and metabolic problems. Discussing potential adverse effects with a healthcare provider is vital for monitoring and informed decisions. Do not stop Invega without consulting a doctor due to relapse risk. Invega Sustenna: Uses, Dosage, Side Effects, Warnings - Drugs.com
