What is Dexlansoprazole?
Dexlansoprazole is the active ingredient in Dexilant and is the official generic name for this medication. Like its brand-name counterpart, dexlansoprazole is a proton pump inhibitor (PPI), a class of drugs that works by reducing the amount of acid produced in the stomach. The generic version is manufactured by several companies, and like all FDA-approved generics, it contains the same active ingredients and is held to the same high standards for quality, safety, and effectiveness as the brand-name drug.
The Unique Dual-Release Mechanism
One feature that sets dexlansoprazole apart from other PPIs is its unique dual-release formulation. The delayed-release capsule contains two types of granules with different pH-dependent coatings. Approximately 25% of the dose is released quickly in the duodenum (the first part of the small intestine), while the remaining 75% is released later in the distal small intestine. This staggered release pattern results in two distinct peak concentrations of the drug in the bloodstream, extending its acid-suppressing effect over a longer period. This mechanism is particularly beneficial for managing nighttime heartburn and other GERD symptoms.
Indications for Dexlansoprazole
Dexlansoprazole is a prescription-only medication used to treat several conditions related to excess stomach acid.
- Healing of Erosive Esophagitis (EE): This condition involves damage to the esophagus from stomach acid.
- Maintenance of Healed Erosive Esophagitis: For those whose EE has healed, dexlansoprazole can be used to maintain healing and provide long-term heartburn relief.
- Symptomatic Non-Erosive Gastroesophageal Reflux Disease (GERD): Dexlansoprazole can treat the heartburn associated with symptomatic non-erosive GERD.
Benefits of Choosing the Generic Version
For many patients, the most significant advantage of opting for the generic dexlansoprazole is the potential for considerable cost savings. Brand-name drugs are often expensive due to the costs associated with research, development, and marketing. Once the patent expires, other manufacturers can produce generic versions, which creates market competition and drives down the price. Before making a switch, it is always recommended to consult with your doctor, pharmacist, or insurance provider, as coverage can vary.
Potential Side Effects
As with any medication, dexlansoprazole can cause side effects. Most are mild to moderate and may include:
- Diarrhea
- Stomach pain
- Nausea and vomiting
- Headache
- Gas (flatulence)
- Upper respiratory tract infections, such as the common cold
Serious side effects, though less common, can occur, especially with long-term use. These include:
- Low Magnesium Levels (Hypomagnesemia): Symptoms may include muscle spasms, irregular heartbeats, or seizures. This risk is higher with long-term use or if other medications are taken concurrently.
- Bone Fractures: An increased risk of hip, wrist, or spine fractures has been reported, particularly in older adults or those taking high doses for a year or longer.
- Vitamin B12 Deficiency: Prolonged use (over three years) can lead to low vitamin B12 levels, causing symptoms like weakness and numbness.
- C. difficile Diarrhea: Some studies suggest PPI therapy may be linked to a higher risk of this severe form of diarrhea, especially in hospitalized patients.
- Acute Interstitial Nephritis (AIN): This sudden inflammation of the kidneys can occur at any time during treatment.
Comparison: Dexilant vs. Generic Dexlansoprazole
| Feature | Dexilant (Brand Name) | Dexlansoprazole (Generic) |
|---|---|---|
| Active Ingredient | Dexlansoprazole | Dexlansoprazole |
| FDA Approval | Yes | Yes (Must meet same FDA standards) |
| Effectiveness | Bioequivalent to the generic version | Bioequivalent to the brand-name version |
| Formulation | Dual delayed-release capsule | Dual delayed-release capsule (exact replica) |
| Cost | Typically higher than the generic | Generally more affordable than the brand name |
| Availability | Available since 2009 | Widely available in pharmacies since 2022 |
How to Take Dexlansoprazole
Dexlansoprazole is a delayed-release capsule. It is typically taken once daily, and unlike some other PPIs, it can be taken with or without food. The capsules should be swallowed whole. For those with difficulty swallowing, the contents can be sprinkled onto a tablespoon of applesauce and consumed immediately. Following a doctor’s instructions carefully is crucial for effective treatment and minimizing risks.
Conclusion
For patients seeking an affordable and effective alternative to the brand-name medication Dexilant, the answer to "what's the generic for Dexilant?" is dexlansoprazole. This generic PPI offers the same unique dual-release technology and therapeutic benefits for treating GERD and erosive esophagitis. By understanding the similarities and differences, patients can make informed decisions in consultation with their healthcare provider to manage their acid-related conditions effectively and economically. For detailed information on its uses and potential risks, the Mayo Clinic provides comprehensive information on dexlansoprazole.
