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What are the side effects of gas drops?

4 min read

Infantile colic, characterized by excessive crying, prompts 10% to 20% of pediatrician visits for infants in their first few weeks of life [1.5.5]. Many parents turn to over-the-counter remedies, but it's crucial to ask: what are the side effects of gas drops?

Quick Summary

Gas drops, with the active ingredient simethicone, are considered very safe because they are not absorbed into the bloodstream. Side effects are rare, but can include mild diarrhea. The main risk is a rare but serious allergic reaction.

Key Points

  • High Safety Profile: Simethicone, the active ingredient, is not absorbed into the bloodstream, making side effects very rare [1.2.1].

  • Physical Mechanism: It works by physically breaking down large gas bubbles into smaller ones, making them easier to pass [1.4.4].

  • Allergic Reactions: Though rare, severe allergic reactions (rash, swelling, difficulty breathing) are possible and require immediate medical attention [1.3.2].

  • Thyroid Medication Interaction: Gas drops can interfere with the absorption of thyroid medications like levothyroxine; doses should be separated by at least 4 hours [1.6.2].

  • Minimal Common Side Effects: When side effects do occur, they are typically mild, such as diarrhea or nausea [1.2.1, 1.2.7].

  • Alternatives Exist: Non-medical options like burping techniques, 'bicycle legs,' and tummy time can also be effective for relieving infant gas [1.8.1].

  • Not for All Colic: Some studies indicate simethicone may not be more effective than a placebo for infantile colic, though it is considered safe to try [1.7.1].

In This Article

Understanding Gas Drops and Their Active Ingredient

Gas drops are a common over-the-counter (OTC) remedy used to relieve symptoms of excess gas in infants, children, and adults [1.2.6]. The primary active ingredient in most gas drops, such as Mylicon and Gas-X, is simethicone [1.2.5]. It is an anti-foaming agent designed to alleviate discomfort, pressure, and bloating caused by gas trapped in the digestive tract [1.2.5]. Simethicone is recognized by the U.S. Food and Drug Administration (FDA) as a safe and effective treatment for gas [1.4.7]. It is available in various forms, including liquid drops for infants and chewable tablets or capsules for older children and adults [1.4.7].

How Simethicone Works

Simethicone works through a physical, rather than chemical, mechanism [1.4.3]. It acts as a surfactant, which means it lowers the surface tension of gas bubbles in the stomach and intestines [1.4.4]. This action breaks large, trapped gas bubbles into smaller ones, allowing them to be more easily passed from the body through burping or flatulence [1.4.4]. A key aspect of its safety profile is that simethicone is not absorbed into the bloodstream [1.4.1]. It works locally in the gastrointestinal tract and is excreted unchanged in the feces, which is why systemic side effects are not expected [1.2.1, 1.4.4].

Common and Rare Side Effects

Because simethicone is not absorbed by the body, it has a high safety profile and side effects are very uncommon [1.2.3]. Most people who use gas drops experience no adverse effects at all [1.3.7].

Minor Side Effects

In the rare instances that side effects do occur, they are typically mild and gastrointestinal in nature. These can include:

  • Diarrhea [1.2.1]
  • Nausea [1.2.1, 1.3.5]
  • Constipation [1.3.5]

Severe Side Effects and Allergic Reactions

A serious allergic reaction to simethicone is rare but requires immediate medical attention [1.2.3]. If you or your child experience any of the following symptoms after taking gas drops, seek help right away [1.3.2, 1.3.6]:

  • Skin Reactions: Rash, hives, itching, or red, swollen, or peeling skin [1.3.2].
  • Swelling: Swelling of the face, lips, tongue, or throat [1.3.2].
  • Breathing Difficulties: Wheezing, tightness in the chest or throat, or trouble breathing [1.3.2, 1.3.4].
  • Other Symptoms: Severe dizziness, unusual hoarseness, trouble swallowing, or a racing heart [1.3.2, 1.3.4].

Drug Interactions

While simethicone has few interactions, one significant interaction is with thyroid medication, such as levothyroxine [1.6.4]. Simethicone can decrease the absorption of thyroid hormones, reducing their effectiveness [1.6.2]. To avoid this, it is recommended to take simethicone at least four hours apart from any thyroid medication [1.6.1, 1.6.2]. Always inform your doctor or pharmacist about all medications, supplements, and herbs you are taking to prevent potential interactions [1.3.3].

Gas Relief Options: A Comparison

Parents often consider several options for infant gas relief. Here’s how simethicone gas drops compare to other popular remedies.

Remedy Active Component/Mechanism FDA Regulation Known Side Effects
Simethicone Gas Drops A non-absorbed, anti-foaming agent that breaks up gas bubbles [1.4.3, 1.7.3]. Regulated as an OTC drug; recognized as safe and effective [1.4.7, 1.7.3]. Very rare; may include mild diarrhea or nausea [1.2.1].
Gripe Water An herbal supplement, often containing ginger and fennel [1.7.4]. Not regulated by the FDA as a drug; classified as a dietary supplement [1.8.4]. Varies by brand; safety and effectiveness are not well-researched [1.8.4].
Probiotics Live microorganisms (e.g., Lactobacillus reuteri) intended to balance gut bacteria [1.7.6]. Regulated as dietary supplements, not as drugs. Generally considered safe, but evidence for infant gas relief is still emerging [1.7.6].

Some studies suggest that simethicone may not be more effective than a placebo for treating infantile colic [1.7.1, 1.7.2]. However, its strong safety profile makes it a common first choice for many parents and pediatricians [1.7.3, 1.8.4].

Non-Pharmacological Alternatives for Gas Relief

Before or alongside medication, several techniques can help relieve gas, particularly in infants:

  • Proper Feeding Position: Feed your baby in a more upright position to reduce air swallowing [1.8.5].
  • Burping: Burp your baby both during and after feedings [1.8.1].
  • Leg Movements: Lay your baby on their back and gently move their legs in a bicycling motion [1.8.2].
  • Tummy Time: Supervised tummy time can help put gentle pressure on the abdomen to release trapped gas [1.8.5].
  • Belly Massage: Gently massaging your baby's tummy in a clockwise motion may also help [1.8.6].

Conclusion

Overall, gas drops containing simethicone are considered exceptionally safe for relieving gas discomfort in both infants and adults. Their mechanism of action, which is confined to the gastrointestinal tract without being absorbed into the body, results in a very low incidence of side effects [1.2.1, 1.4.4]. The most significant, though very rare, risk is an allergic reaction, the signs of which should be known to all caregivers [1.3.2]. When using gas drops, it's vital to be aware of the potential interaction with thyroid medication and to explore non-pharmacological comfort measures that can also provide relief [1.6.4, 1.8.1]. Always follow package directions and consult a healthcare provider with any concerns.


Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication or treatment.

Cleveland Clinic

Frequently Asked Questions

Yes, gas drops containing simethicone are considered safe for use in newborns and infants. The medication is not absorbed into the body, so systemic side effects are not a concern [1.2.6, 1.4.3].

Simethicone gas drops work quickly to break up gas bubbles, often providing relief within minutes [1.7.4]. For prevention, some doctors recommend using them regularly with feedings [1.8.4].

While it is important to follow the dosage instructions on the label, simethicone is considered to have no known toxicity. If you suspect an overdose, you should still contact a poison control center or emergency room [1.4.2, 1.2.5].

Side effects from gas drops are uncommon. However, in rare cases, they have been associated with mild diarrhea or constipation [1.2.1, 1.3.1, 1.3.5].

The most notable drug interaction is with thyroid medications, like levothyroxine. Gas drops can reduce the absorption of these drugs, so they should be taken at least 4 hours apart [1.6.4].

A rare but serious allergic reaction can include a skin rash or hives, swelling of the face, tongue or throat, and difficulty breathing or swallowing. Seek immediate medical help if these symptoms occur [1.3.2, 1.3.7].

Simethicone gas drops are regulated by the FDA and are not absorbed by the body, giving them a well-established safety profile. Gripe water is an herbal supplement and is not regulated by the FDA, and its safety and effectiveness have not been as thoroughly researched [1.7.3, 1.8.4].

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.