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What is in revaree suppositories? A Pharmacological Breakdown

4 min read

Studies have demonstrated that hyaluronic acid, the key hydrating agent in Revaree suppositories, can be as effective as topical estrogen in addressing symptoms of vaginal dryness. The hormone-free vaginal insert works by attracting and retaining moisture within vaginal tissues to provide lasting relief.

Quick Summary

Revaree vaginal inserts consist of the active ingredient hyaluronic acid sodium salt within a base of semi-synthetic glycerides. This formulation hydrates and helps restore vaginal tissue to alleviate dryness and discomfort.

Key Points

  • Hyaluronic Acid is the Active Ingredient: Revaree's main component, hyaluronic acid, is a naturally occurring molecule that attracts and retains moisture, effectively hydrating vaginal tissue.

  • Hydrates and Restores Tissue: The hyaluronic acid in Revaree draws moisture to the vaginal lining, helping to heal thinning and damaged tissue and restore elasticity.

  • Semi-Synthetic Glycerides Form the Base: A base of semi-synthetic glycerides, derived from palm and palm kernel, ensures the suppository melts at body temperature to release the active ingredient.

  • Revaree Plus Offers Enhanced Hydration: The 'Plus' version contains twice the hyaluronic acid (10mg vs 5mg) and adds sweet almond oil for extra moisturization.

  • Hormone-Free Formulation: Revaree provides localized, hormone-free relief, making it a suitable option for many women who prefer or need to avoid hormonal treatments.

  • Not Compatible with Condoms: Both the standard and 'Plus' formulations of Revaree are incompatible with certain types of condoms, including those made from latex.

In This Article

The Primary Active Ingredient: Hyaluronic Acid

The core component of Revaree suppositories is hyaluronic acid sodium salt, a molecule found naturally throughout the body. A remarkable feature of hyaluronic acid is its ability to attract and retain significant amounts of moisture—up to 1,000 times its own weight in water. When inserted into the vagina, this ingredient rehydrates the vaginal tissue, which can become thin, dry, and fragile, particularly during menopause. By drawing moisture to the area, hyaluronic acid helps create a healing environment that repairs and restores the vaginal lining. This process increases tissue strength, improves elasticity, and helps reduce symptoms like burning, itching, and painful intercourse (dyspareunia). Clinical trials have shown that the relief provided by hyaluronic acid is comparable to that of low-dose topical estrogen creams, offering a valuable hormone-free alternative for women who cannot or prefer not to use hormone therapy.

The Suppository Base: Semi-Synthetic Glycerides

To ensure the effective delivery of hyaluronic acid, Revaree uses a base of semi-synthetic glycerides. These are a mixture of triglycerides, diglycerides, and monoglycerides derived from palm and palm kernel. The primary function of this base is to give the vaginal insert its shape and allow it to melt consistently at body temperature once inserted. As the base melts, it releases the hyaluronic acid, which can then be absorbed by the vaginal mucosa to begin its hydrating and restorative work. The glyceride base is designed to be well-tolerated and to minimize leakage. Some customers with specific sensitivities or allergies have noted the palm and palm kernel derivatives, and transparency about these inactive ingredients is important for consumer health awareness.

A Comparison: Standard Revaree vs. Revaree Plus

Revaree is available in a standard formulation and an enhanced 'Plus' version. Understanding the difference between these products is key to choosing the right one for individual needs. The core difference lies in the concentration of hyaluronic acid and the addition of another moisturizing ingredient in the 'Plus' version.

Feature Standard Revaree Revaree Plus
Hyaluronic Acid Content 5 mg hyaluronic acid sodium salt 10 mg hyaluronic acid sodium salt (twice the amount)
Additional Ingredients None, beyond the base Soothing sweet almond oil
Recommended For General, long-term relief from vaginal dryness Extra-strength relief for more severe dryness or discomfort
Allergy Note No specific nut allergens Contains refined sweet almond oil; avoid if you have a known almond allergy
Condom Compatibility Not compatible with natural rubber latex, polyurethane, and polyisoprene condoms Not compatible with natural rubber latex, polyurethane, and polyisoprene condoms

How the Pharmacology Works for Relief

The mechanism of action for Revaree is rooted in the unique properties of its active ingredient, hyaluronic acid. Here is a step-by-step look at how the suppositories work:

  • Insertion and Melting: A user inserts the solid suppository vaginally, typically at bedtime to maximize absorption and minimize leakage. The suppository base of semi-synthetic glycerides then melts from body heat.
  • Moisture Absorption: Once released, the hyaluronic acid begins to draw and hold water from surrounding tissues and internal moisture. This process is called hygroscopy. It creates a gelatinous film or moist layer that lubricates and coats the vaginal lining.
  • Hydration and Repair: The continuous hydration helps plump and strengthen the vaginal mucosa, which counteracts the thinning and damaging effects of hormonal changes associated with menopause. Over time, this helps to rejuvenate the tissue.
  • Symptom Reduction: By restoring natural moisture and promoting tissue repair, the product effectively reduces symptoms such as dryness, itching, burning, and pain during sex. Clinical studies and customer surveys confirm significant improvement in these areas within weeks of starting treatment.
  • Hormone-Free: Unlike hormone replacement therapies, Revaree's action is localized and does not affect systemic estrogen levels. This makes it a safe option for women who are not candidates for or prefer to avoid hormonal treatments.

Important Safety and Usage Information

For optimal results and to ensure safety, users should be aware of a few key points. Revaree is generally considered safe and effective, cleared by the FDA as a Class II Medical Device. However, specific precautions are necessary.

  • Allergies: Those with known almond allergies should choose the standard Revaree product, as Revaree Plus contains refined sweet almond oil. It is always recommended to review the full ingredients list if you have other sensitivities. The base of semi-synthetic glycerides contains palm and palm kernel byproducts.
  • Condom Compatibility: Neither the standard Revaree nor the Revaree Plus formula is compatible with natural rubber latex, polyurethane, and polyisoprene condoms. Other forms of birth control or barrier methods should be used.
  • Best Practices: Use the insert every 2-3 nights, or as advised by a healthcare provider. For best absorption and to reduce potential mess, insert at bedtime and remain lying down for at least 30 minutes afterward. Some residual discharge may occur in the morning, which is normal.

Conclusion

In conclusion, what is in Revaree suppositories is a straightforward, hormone-free formulation designed to combat vaginal dryness. Its primary active ingredient is hyaluronic acid, which provides deep hydration and promotes the healing of vaginal tissue. This is delivered via a melting base of semi-synthetic glycerides. For those seeking enhanced moisture, Revaree Plus offers a higher concentration of hyaluronic acid and the addition of soothing sweet almond oil. Clinical evidence supports the effectiveness of this approach, providing a safe and reliable option for many women. Based on information from Bonafide Health, the manufacturer, and verified ingredient lists, consumers can be well-informed about this over-the-counter solution.

Frequently Asked Questions

The main active ingredient in Revaree suppositories is hyaluronic acid sodium salt, which is a powerful hydrating agent.

Hyaluronic acid works by attracting and retaining moisture in the vaginal tissue, which helps to repair thinning and damaged tissue and restore its natural hydration.

No, Revaree is a hormone-free product. Its mechanism relies on the hydrating properties of hyaluronic acid rather than hormonal action.

Revaree Plus contains twice the amount of hyaluronic acid (10mg vs. 5mg) and includes sweet almond oil for extra moisturizing and soothing effects.

If you have an almond allergy, you should avoid Revaree Plus, as it contains sweet almond oil. Standard Revaree does not contain almond oil.

No, neither the standard Revaree nor the 'Plus' version is compatible with natural rubber latex, polyurethane, or polyisoprene condoms.

Semi-synthetic glycerides serve as the suppository base, helping it retain its shape until it melts at body temperature to release the hyaluronic acid.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.