The Dual History of Serutan
In the mid-20th century, Serutan was a well-known name in American households, primarily for its use as a laxative. Marketed extensively on radio and television from the 1930s to the 1960s, it gained prominence with its memorable advertising slogan, “Read it backwards”. The product was a bulk-forming laxative, intended to provide a "natural" solution to constipation by increasing stool bulk and making it easier to pass. It was positioned as a gentle alternative to harsher chemical laxatives.
Over the decades, the J.B. Williams Co., which manufactured Serutan, went through several acquisitions and ownership changes. The original bulk-forming product eventually ceased production or was discontinued in its widespread, historical form. The brand name, however, has reappeared on different formulations in other markets, leading to modern confusion about its purpose.
Modern Serutan: A Pancreatic Enzyme Supplement
In contemporary pharmacology, particularly in some international markets, products sold under the name 'Serutan' are not laxatives but rather pancreatic enzyme supplements. These tablets contain pancreatin, a mixture of digestive enzymes (lipase, amylase, and protease) derived from the pancreas of animals, typically pigs. This modern formulation works by supplementing the body's natural digestive enzymes, helping to break down fats, carbohydrates, and proteins.
Medical Conditions Treated with Pancreatin-based Serutan
The modern pancreatin-based Serutan is prescribed for individuals with exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough enzymes for proper digestion. This deficiency can result from several medical conditions, including:
- Cystic Fibrosis: A genetic disorder affecting the lungs and digestive system, often causing a blockage of the pancreatic duct.
- Chronic Pancreatitis: A long-term inflammation of the pancreas that can destroy the enzyme-producing cells.
- Pancreatectomy: Surgical removal of all or part of the pancreas.
- Pancreatic Cancer: The presence of a tumor can interfere with pancreatic function.
- Steatorrhea: The supplement can treat fatty, foul-smelling stools caused by poor fat absorption.
Comparison: Old vs. New Serutan and Other Laxatives
To clarify the difference between the historical and modern versions of Serutan, as well as its distinction from other common laxatives, the following table provides a comparison:
| Feature | Original Serutan (Laxative) | Modern Serutan (Enzyme) | Common Laxatives (e.g., Miralax) |
|---|---|---|---|
| Primary Use | Constipation relief | Treat pancreatic enzyme deficiency | Constipation relief |
| Mechanism | Bulk-forming (adds fiber and water to stool) | Pancreatin supplements aid in digestion of nutrients | Osmotic (draws water into the bowel) or stimulant (promotes muscle contractions) |
| Active Ingredient | Historically psyllium, though formulations varied | Pancreatin (mixture of enzymes) | Polyethylene glycol (Miralax) or senna (stimulant) |
| Product Status | No longer widely available or manufactured in original form | Available in some regions as a prescription medication | Widely available over-the-counter |
| Primary Symptom Relief | Hard, difficult-to-pass stools | Poor nutrient absorption, bloating, fatty stools | Infrequent bowel movements, straining |
How to Take Modern Serutan
For those prescribed the modern pancreatic enzyme supplement, it is crucial to follow the administration instructions to ensure effectiveness and avoid side effects. The pancreatin tablets should be taken during or immediately after meals or snacks. This timing allows the enzymes to mix with the food and aid in digestion.
Important administration guidelines:
- Swallow Whole: Do not crush, chew, or hold the tablet or capsule in your mouth, as this can cause mucosal irritation.
- Drink Water: Take the medication with plenty of water to ensure it travels correctly down the digestive tract.
- Fluid Intake: Increasing overall fluid intake throughout the day is often recommended.
Side Effects and Contraindications
As with any medication, the modern pancreatin-based Serutan can cause side effects. Common adverse effects include:
- Nausea and vomiting
- Diarrhea or constipation
- Stomach pain and bloating
Less common or more severe side effects can include allergic reactions (rash, swelling) and an increase in blood uric acid levels, which can worsen gout.
Before taking this medication, individuals should discuss their medical history with a doctor, especially if they have:
- Allergies to pork products
- Gout or hyperuricemia
- Severe kidney or liver disease
- Other gastrointestinal disorders like Crohn's disease
Conclusion
The name 'Serutan' represents a fascinating pharmaceutical evolution, shifting from a widely advertised bulk-forming laxative in the 20th century to a modern pancreatic enzyme supplement used to manage serious digestive conditions. The historical product is largely no longer available, and anyone encountering a product with this name today is likely looking at the pancreatin-based medication. Understanding this critical distinction is essential for proper use and to ensure the correct treatment for a specific medical need. Always consult with a healthcare professional before starting any new medication to confirm the correct diagnosis and treatment plan for your condition.
