What is Beklo and its active ingredient?
Beklo is a brand name for baclofen, a centrally acting skeletal muscle relaxant used to alleviate muscle spasms, cramping, and tightness by relaxing certain muscles. Its effects primarily occur at the spinal cord level. Beklo is available only with a prescription.
Primary uses and indications
Beklo is mainly used to treat spasticity from neurological conditions, including multiple sclerosis, spinal cord injuries and diseases, cerebrovascular accidents (stroke), and certain brain diseases. It is also indicated for flexor spasms and associated pain, clonus, and muscle rigidity. While some sources mention its use for skeletal muscle spasms from rheumatic disorders, others suggest it's not typically recommended for this.
How Beklo works to relieve spasticity
Beklo works in the central nervous system, particularly the spinal cord, by acting as a GABA-B receptor agonist. This action inhibits monosynaptic and polysynaptic reflexes, reducing muscle spasms. It also blocks the release of excitatory neurotransmitters, which decreases neuronal excitability and promotes muscle relaxation. Beklo also has general CNS depressant effects, which can cause drowsiness.
Dosage and administration
Beklo dosage is individualized and must be taken as prescribed. Treatment typically starts low and increases gradually. Oral forms are often taken with food to reduce nausea. Abruptly stopping Beklo, especially after long-term use, can cause severe withdrawal symptoms like seizures and fever; any dosage changes should be managed by a doctor who will likely recommend gradual reduction.
Comparison of oral vs. intrathecal baclofen delivery
For severe spasticity, baclofen can be delivered directly into the spinal cord via an implanted pump (intrathecal baclofen therapy). This method uses lower doses for a more potent, localized effect compared to oral administration.
| Feature | Oral Baclofen | Intrathecal Baclofen |
|---|---|---|
| Administration | Tablets, solution, or granules by mouth. | Liquid delivered into CSF via implanted pump. |
| Dosage | Higher doses needed. | Much lower doses needed. |
| Effectiveness | Effective but may cause systemic side effects. | Highly effective for severe spasticity with reduced systemic side effects. |
| Onset of Action | Slower onset. | Faster onset (within 30-60 mins for bolus). |
| Side Effects | Common systemic effects like drowsiness and dizziness. | Can include hypotonia; fewer systemic effects. |
| Management | Doctor's prescription and standard follow-ups. | Requires surgery and regular refills. |
Potential side effects
Common side effects of Beklo include drowsiness, dizziness, weakness, fatigue, nausea, constipation, headache, insomnia, and frequent urination. Less common or more serious reactions can include confusion, hallucinations, depression, low blood pressure, vision disturbances, and respiratory depression. Abrupt withdrawal can cause severe complications, including seizures.
Contraindications and precautions
Beklo is contraindicated in those with hypersensitivity to baclofen. Its effects are increased by alcohol and other CNS depressants. Lower doses may be needed for patients with kidney issues. Close monitoring is required for individuals with psychiatric disorders or epilepsy. Stroke patients may tolerate it poorly. Its safety during pregnancy is not fully established, and it is present in breast milk; use should be cautious and only if benefits outweigh risks.
Conclusion
Beklo, containing baclofen, is a crucial prescription medication for managing severe muscle spasticity from conditions like multiple sclerosis and spinal cord injuries. It works at the spinal cord to reduce rigidity, spasms, and pain by activating GABA-B receptors. Due to potential side effects and severe withdrawal risks, Beklo must be used under a physician's care with gradual dosage adjustments. Patients should inform their doctor about all health conditions and medications to ensure safe use. For comprehensive information, consult resources like Drugs.com.
