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What is the OTC version of azelastine and how does it differ?

4 min read

In June 2021, the FDA approved a prescription-to-over-the-counter switch for azelastine hydrochloride nasal spray, making it the first of its class to become available without a prescription. This landmark decision made many consumers wonder: what is the OTC version of azelastine?

Quick Summary

Astepro Allergy is the full-prescription-strength, over-the-counter version of azelastine nasal spray for adults and children aged 6 and older. It provides fast-acting and long-lasting relief from nasal allergy symptoms.

Key Points

  • Astepro Allergy is the OTC version: The full-prescription-strength (0.15%) version of azelastine is now available over the counter as Astepro Allergy.

  • Fast, 24-hour relief: Astepro Allergy starts working in as little as 30 minutes and provides symptom relief for up to 24 hours.

  • Steroid-free antihistamine: It works by blocking histamine to relieve symptoms like congestion, sneezing, and runny nose, differentiating it from steroid sprays.

  • Key side effects include drowsiness: A bitter taste and drowsiness are possible side effects, so use caution when driving or operating machinery.

  • Different strengths available: While the 0.15% strength is OTC, a prescription is still required for the 0.1% azelastine nasal spray.

  • Consult a healthcare provider: It is best to consult a professional for severe, chronic, or non-allergic rhinitis to ensure the best treatment plan.

  • Convenient availability: The OTC version can be purchased directly from pharmacies and retailers without a doctor's visit.

In This Article

Introducing Astepro Allergy: The Over-the-Counter Solution

Prior to 2021, azelastine nasal spray was only available by prescription. However, the FDA approved the 0.15% strength of azelastine hydrochloride nasal spray for nonprescription use, which is now sold under the brand name Astepro Allergy. This over-the-counter version offers adults and children ages 6 and older a powerful, full-prescription-strength option for treating seasonal and perennial nasal allergy symptoms.

Unlike many common nasal sprays, Astepro Allergy is a steroid-free antihistamine that gets to work quickly, with some users experiencing symptom relief in as little as 30 minutes. It is formulated to provide up to 24 hours of relief from common allergy symptoms, including:

  • Nasal congestion
  • Runny nose
  • Sneezing
  • Itchy nose

How Azelastine Works to Combat Allergies

Azelastine is a second-generation antihistamine that targets the body's allergic response differently than a steroid. When your body is exposed to an allergen, it releases a chemical called histamine, which causes the classic allergy symptoms. Astepro Allergy works by blocking the histamine receptors, which helps to reduce the swelling and irritation in your nasal passages and minimize allergy symptoms. Steroid nasal sprays, on the other hand, reduce inflammation through a different, often slower-acting, mechanism.

Differentiating OTC Astepro from Prescription Azelastine

While the OTC and prescription versions of azelastine share the same active ingredient, there are some important distinctions to be aware of:

  • Strength: The OTC Astepro Allergy is available exclusively in the 0.15% strength. In contrast, the prescription version is available in both 0.1% and 0.15% strengths. The 0.1% strength of azelastine remains a prescription-only product.
  • Cost and Availability: The OTC version of Astepro is a brand-name product found in pharmacies and retailers without a prescription. A healthcare professional can also write a prescription for azelastine, which may allow for a lower-cost generic option, depending on your insurance.
  • Indications: The OTC product is approved for treating seasonal and perennial allergic rhinitis in patients aged 6 and older. Some prescription versions may also be indicated for other conditions, such as vasomotor rhinitis.

Comparing Astepro Allergy to Other Nasal Sprays

Understanding the various types of over-the-counter nasal sprays can help you choose the best option for your specific symptoms. Here is a comparison of Astepro Allergy with other popular OTC nasal spray types:

Nasal Spray Type Active Ingredient Speed of Relief Primary Action Best For Potential Side Effects
Astepro Allergy (Antihistamine) Azelastine HCl (0.15%) Fast (~30 min) Blocks histamine receptors Itchy nose, sneezing, runny nose, congestion Bitter taste, drowsiness
Flonase / Nasacort (Corticosteroid) Fluticasone, Triamcinolone, etc. Slower (up to 2 weeks for full effect) Reduces inflammation Most effective for overall allergy symptoms, including congestion and eye symptoms Nosebleeds, headaches, sore throat
Afrin (Decongestant) Oxymetazoline Very fast Constricts blood vessels Temporary, rapid relief of nasal congestion Rebound congestion with overuse (3-day limit)
NasalCrom (Mast Cell Stabilizer) Cromolyn sodium Slower (up to 4 weeks for full effect) Prevents the release of inflammatory chemicals Preventing allergy symptoms over time, especially with consistent use Local irritation

How to Use Astepro Allergy Correctly

To ensure the best results from your Astepro Allergy spray, it is important to follow the directions for use carefully:

  1. Wash your hands and gently blow your nose to clear your nasal passages.
  2. Prime the pump by spraying it into the air until a fine mist appears, especially if it is the first use or if it has been unused for three or more days.
  3. Tilt your head slightly forward and insert the nozzle into one nostril, aiming the spray toward the back of your nasal passage.
  4. Close the other nostril with your finger and spray while gently sniffing.
  5. Repeat the process for the other nostril.
  6. Wipe the nozzle clean and replace the protective cap.

Potential Side Effects and Precautions

Like any medication, Astepro Allergy can cause side effects. The most commonly reported side effects include a bitter taste in the mouth, drowsiness, and nasal discomfort. The warning label advises caution when operating machinery or driving, especially when first starting the medication, due to the risk of drowsiness. It is also recommended to avoid alcohol, sedatives, or tranquilizers while using the product. Consult a healthcare provider before use if you are pregnant, nursing, or have a history of nosebleeds, as outlined in information from the Mayo Clinic.

Conclusion: Choosing the Right Allergy Relief

The introduction of Astepro Allergy has provided a convenient, over-the-counter azelastine option for allergy sufferers seeking quick and effective relief. As a powerful, steroid-free antihistamine, it offers a strong alternative to oral medications and slower-acting steroid nasal sprays. However, the best choice of allergy relief depends on your specific symptoms and needs. Always consult with a healthcare professional, such as your doctor or pharmacist, to determine if Astepro Allergy or another treatment is right for you, especially for long-term or severe allergy management.

Frequently Asked Questions

Astepro Allergy contains the same active ingredient, azelastine hydrochloride, at the same 0.15% strength as the strongest prescription version. However, the lower 0.1% strength is still available by prescription only.

The over-the-counter version of Astepro Allergy is fast-acting, with some users reporting relief from symptoms in as little as 30 minutes.

Astepro Allergy is indicated for relieving nasal symptoms due to hay fever or other upper respiratory allergies. For non-allergy related rhinitis, a prescription version of azelastine may be indicated, but consult a healthcare provider for proper diagnosis and treatment.

The over-the-counter formulation of Astepro Allergy is approved for use in adults and children aged 6 years and older. For children under 6, use is not recommended unless directed by a doctor.

Astepro Allergy can be used as an add-on treatment in addition to oral antihistamines. However, you should avoid other medications that cause sleepiness and consult your doctor before combining different allergy medicines.

A bitter taste in the mouth is the most common side effect associated with azelastine nasal spray. Drowsiness and nasal discomfort are also possible.

Decongestant nasal sprays like Afrin can cause rebound congestion if used for more than three days. Astepro Allergy is a different class of medication (antihistamine) and does not cause rebound congestion. It is suitable for regular, long-term use during allergy season.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.