What is the use of Pdfact gel? A guide to its function and application

October 7, 2025 •

3 min read

According to Apollo Pharmacy, Pdfact Gel is a topical medication primarily used to treat diabetic foot ulcers. The gel contains the active ingredient becaplermin, a recombinant human platelet-derived growth factor, which works by actively promoting the growth of cells involved in wound healing. The primary use of Pdfact gel is specifically for diabetic neuropathic ulcers with adequate blood flow.

Quick Summary

Pdfact gel is a topical treatment for diabetic foot ulcers containing the active ingredient becaplermin, which stimulates wound healing and cell growth. It is intended for ulcers in patients with sufficient blood flow and must be used under medical supervision as part of a complete wound care regimen.

Key Points

Specific Indication: The primary use of Pdfact gel is for treating lower extremity diabetic neuropathic ulcers that have adequate blood supply.
Active Ingredient: The gel's active component is becaplermin, a recombinant human platelet-derived growth factor BB, which stimulates cellular wound healing.
Proper Application: For maximum benefit, the gel should be applied in a thin, even layer to a cleaned wound and covered with a saline-moistened gauze dressing. The frequency of application will be determined by a healthcare provider.
Not for All Ulcers: It is not effective for pressure ulcers or those resulting from poor blood circulation, and requires a medical evaluation to confirm suitability.
Part of Comprehensive Care: Pdfact gel is an adjunct therapy and must be used alongside other standard diabetic foot care practices, such as proper footwear and blood sugar control.
Potential Side Effects: Common side effects include temporary burning and redness at the application site, and patients should be monitored for any unusual reactions.
Contraindications: Patients with skin cancer at the application site should not use this gel, and precautions are necessary for pregnant or breastfeeding individuals.

Understanding the Mechanism of Action

Pdfact Gel contains becaplermin, a recombinant human platelet-derived growth factor BB (rhPDGF-BB). This ingredient mimics natural growth factors to accelerate wound healing by attracting cells like fibroblasts to the wound site, stimulating their growth, and promoting new tissue and blood vessel formation. This process is crucial for healing diabetic ulcers, where the body's natural repair mechanisms may be impaired.

Indications for Use: Specific Wound Healing

Pdfact Gel is specifically prescribed for lower extremity diabetic neuropathic ulcers that have adequate blood supply and extend into the subcutaneous tissue. It's used as part of a complete wound care plan, including debridement and infection management. The gel is not suitable for ulcers caused by poor blood flow or pressure ulcers. Sufficient circulation is necessary for the treatment to be effective, and regular assessment of blood flow is recommended.

Proper Application Procedure

Correct application of Pdfact Gel is vital and should follow healthcare professional instructions.

Step-by-step application guide:

Clean and debride the ulcer, then rinse with saline and dry.
Dispense the prescribed amount onto a clean surface.
Apply a thin layer over the entire ulcer with a clean applicator, avoiding contact between the tube and the wound.
Cover with a saline-moistened gauze dressing, keeping it moist.
Secure the dressing without applying pressure; avoid occlusive bandages unless directed by a doctor.
The frequency of application will be determined by a healthcare provider, and the wound should be regularly monitored.

Contraindications and Potential Side Effects

Pdfact Gel is not suitable for everyone. It is contraindicated in patients with skin cancer at the application site and is not recommended for children under 16. Common side effects can include temporary burning and redness at the application site, which usually subside. Patients should contact their doctor if side effects persist or worsen. Serious allergic reactions are rare but require immediate medical attention. Patients should inform their doctor of their medical history, allergies, and other conditions. Pregnant or breastfeeding individuals should consult their doctor to weigh risks and benefits.

Comparison of Pdfact Gel vs. Conventional Wound Care


Feature	PdFact Gel (Becaplermin)	Conventional Wound Care
Mechanism	Stimulates cell growth and new tissue formation via growth factors.	Focuses on providing a moist, sterile environment and debridement.
Speed of Healing	Can significantly accelerate the healing process compared to conventional methods.	Healing time is often slower and may be less consistent for chronic ulcers.
Suitability	Best for neuropathic diabetic ulcers with good blood supply.	Applicable to a broader range of wounds, but may be insufficient for chronic ulcers.
Adjunctive Use	Works best when combined with standard, comprehensive wound care.	Is the baseline treatment for wound management.
Biological Action	Delivers targeted, bio-engineered growth factors.	Relies on the body's intrinsic, and often impaired, healing process.

The Role of PdFact Gel in Comprehensive Diabetic Foot Care

Pdfact Gel should be part of a comprehensive diabetic foot care plan, not a standalone treatment. Key components include:

Offloading: Reducing pressure on the affected foot to prevent damage and aid healing.
Blood Sugar Management: Maintaining stable blood glucose levels is crucial for preventing complications and supporting healing.
Infection Control: Managing any ulcer infection, often with antibiotics.
Regular Monitoring: Ongoing wound evaluation by a healthcare professional.

Conclusion

In conclusion, Pdfact gel is primarily used for accelerated treatment of specific diabetic neuropathic foot ulcers with good blood circulation. Its active ingredient, becaplermin, promotes cellular growth to speed wound healing, making it a valuable tool for managing this complication of diabetes. It is a prescription medication requiring medical supervision and integration with standard foot care for optimal results. Patients should discuss their suitability with a doctor and follow all guidelines.

For further reading on diabetic foot ulcer care, you can refer to authoritative sources like the National Institutes of Health (NIH) and other medical journals detailing research on this topic.

Frequently Asked Questions

Pdfact gel is used to treat chronic diabetic foot ulcers, specifically lower extremity neuropathic ulcers that extend into the subcutaneous tissue and have adequate blood supply.

Becaplermin is a recombinant human platelet-derived growth factor BB (rhPDGF-BB) that stimulates the growth and proliferation of cells involved in wound healing, such as fibroblasts, to help close the ulcer.

No, Pdfact gel is specifically for diabetic neuropathic ulcers and is not recommended for pressure ulcers or ulcers resulting from insufficient blood flow.

Common side effects include a burning sensation and a red skin rash at the site of application. These are often temporary but should be reported to a doctor if they persist or worsen.

The gel is applied in a thin, even layer to the cleaned ulcer surface and then covered with a saline-moistened gauze dressing. It is important to follow your doctor's specific instructions on application and frequency.

Safety in pregnancy and breastfeeding has not been fully established. If you are pregnant or breastfeeding, you should consult your doctor to determine if the benefits outweigh the risks.

You should follow a comprehensive wound care plan, which includes offloading pressure from the foot, controlling blood sugar levels, and regular monitoring by a healthcare provider.