What is Trubet 48 SR used for?

October 7, 2025 •

3 min read

Meniere's disease, a chronic condition of the inner ear, is often characterized by debilitating symptoms, including severe vertigo, tinnitus, and hearing loss. Trubet 48 SR is used for managing these specific symptoms associated with this inner ear disorder.

Quick Summary

Trubet 48 SR is a sustained-release form of betahistine prescribed for Meniere's disease symptoms such as vertigo, tinnitus, nausea, and hearing loss by improving inner ear blood flow.

Key Points

Meniere's Disease Treatment: Trubet 48 SR is primarily used to manage the symptoms of Meniere's disease, an inner ear disorder.
Symptom Relief: It is effective in reducing the frequency and intensity of vertigo, tinnitus, and hearing loss associated with the condition.
Mechanism of Action: The active ingredient, betahistine, works by increasing blood flow to the inner ear, which helps regulate fluid pressure.
Sustained-Release Formula: The SR (Sustained-Release) formulation ensures the active ingredient is released slowly over time, providing more consistent symptom relief.
Potential Side Effects: Common side effects include headache, nausea, indigestion, and bloating, which can be mitigated by taking the medication with food.
Important Precautions: The medication is not suitable for individuals with certain conditions like pheochromocytoma, stomach ulcers, or asthma.

What Is Trubet 48 SR and What Are Its Active Ingredients?

Trubet 48 SR is a medication for managing Meniere's disease symptoms, a progressive inner ear disorder. 'SR' signifies 'Sustained-Release,' meaning the medicine is released slowly over time for a consistent effect. Its active ingredient is betahistine, a histamine analogue impacting inner ear blood flow and pressure.

How Trubet 48 SR Helps with Meniere's Disease

Meniere's disease involves excess endolymph fluid buildup in the inner ear, believed to cause symptoms. Betahistine, in Trubet 48 SR, addresses this issue through several mechanisms:

Increasing inner ear blood flow: Betahistine acts on H1 and H3 receptors in inner ear blood vessels, causing vasodilation and improved circulation.
Reducing inner ear pressure: Enhanced blood flow helps regulate and decrease the pressure from fluid buildup, easing vertigo and tinnitus.
Improving vestibular compensation: Long-term use can quicken the central nervous system's adaptation to inner ear dysfunction, potentially offering lasting balance control improvement.

Symptoms Alleviated by Trubet 48 SR

Trubet 48 SR helps relieve various Meniere's disease symptoms:

Vertigo: Reduces the frequency and severity of intense dizzy spells.
Tinnitus: Helps decrease the ringing or buzzing sound in the ears.
Nausea: Can alleviate sickness often accompanying vertigo attacks.
Hearing Loss: May help with hearing fluctuations linked to Meniere's by improving inner ear circulation.

Dosage and Administration

Trubet 48 SR should be taken as prescribed by a healthcare professional. It's best taken with or after food to minimize stomach upset. Taking it at the same time daily helps maintain consistent drug levels. Do not crush, chew, or break sustained-release tablets. Follow your doctor's instructions precisely, as abrupt discontinuation can worsen symptoms.

Potential Side Effects and Precautions

Trubet 48 SR may cause side effects, usually mild and temporary:

Headache
Nausea and indigestion
Abdominal pain or bloating

Taking the tablet with food can help manage stomach issues. Rare serious side effects, like skin rashes or severe allergic reactions, can occur. Seek immediate medical help for signs of a severe allergic reaction, such as facial swelling or breathing difficulties.

Contraindications: Avoid Trubet 48 SR if you have:

Betahistine allergy
History of stomach ulcers
Asthma
Pheochromocytoma (a rare adrenal gland tumor)

Trubet 48 SR vs. Placebo in Clinical Trials

Studies comparing betahistine (in Trubet 48 SR) to a placebo for vertigo and Meniere's have shown positive results in large observational studies and meta-analyses, despite mixed initial findings.


Feature	Trubet 48 SR (Betahistine)	Placebo
Effect on vertigo symptoms	Significant reduction in frequency and severity of attacks	Variable or no significant effect
Impact on tinnitus	Helps reduce ringing or buzzing in the ears	No specific impact documented
Improvement in hearing loss	Helps with hearing fluctuations in some cases	No specific impact documented
Nausea and vomiting relief	Effective in alleviating nausea related to vertigo	No specific relief observed
Overall patient response	High percentage of patients report good or excellent improvement	Subjective improvement may occur due to placebo effect, but typically lower
Lasting effects	Effects can persist for months after treatment cessation due to vestibular compensation	No lasting effects are expected

Source: Based on data from several clinical trials and observational studies of betahistine, including a 2017 study published in PLoS ONE and a 2016 BMJ study.

Conclusion

Trubet 48 SR is a key medication for managing Meniere's disease symptoms like vertigo, tinnitus, and hearing loss. Its sustained-release betahistine formulation provides consistent levels to stabilize the inner ear and reduce attack frequency and severity. While common side effects are manageable, potential interactions and contraindications require medical supervision. Trubet 48 SR can significantly improve the quality of life for those with Meniere's disease by restoring balance and comfort.

For more detailed information on betahistine and related research, refer to authoritative resources from organizations like the National Institutes of Health (NIH).

Frequently Asked Questions

Meniere's disease is a disorder of the inner ear that causes spontaneous attacks of vertigo, a sensation of spinning, along with fluctuating hearing loss and ringing in the ears (tinnitus).

Trubet 48 SR helps alleviate vertigo by increasing blood flow to the inner ear and reducing excess fluid pressure, which stabilizes the inner ear's balance mechanisms.

It is generally recommended to take Trubet 48 SR with or after a meal. This helps to reduce the risk of stomach upset or indigestion, which is a common side effect.

While Trubet 48 SR's active ingredient, betahistine, is often prescribed for vestibular vertigo, its primary indication is for Meniere's disease. A doctor must determine if it is appropriate for other conditions.

If you miss a dose of Trubet 48 SR, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Yes, although rare, allergic reactions can occur. If you experience symptoms like a skin rash, swelling of the face, or difficulty breathing, seek immediate medical attention.

Some patients may notice an improvement within a couple of weeks, but for the full therapeutic effect, it may take several months of consistent treatment.